The invention discloses a manganese zinc ferrite with characteristics of high temperature, low power consumption and high overlaying, and a preparation method of the manganese zinc ferrite. The manganese zinc ferrite comprises ferric oxide, manganese oxide, zinc oxide, calcium carbonate, titanium oxide, cobaltous oxide, silicon oxide, chromic oxide, niobium oxide and vanadium oxide. The manganese zinc ferrite is prepared through the steps of material blending, preburning and crashing, sanding, preparation of granulation slurry, spray granulation, manufacturing of blanks, sintering and the like, and under the test condition of 100KHz 200mT, the power loss at the temperature of 100 DEG C is smaller than 260kw/m<3>, and the Bs at the temperature of 100 DEG C is larger than 420mT; a filter, a switch power source and a transformer application electronic product are partially made of magnetic materials, partial energy is consumed, and an electronic device which is wider in use field, smaller in size, more efficient and saving in energy can be provided for users, the use frequency of the materials is expanded, the loss is reduced, performance of components with magnetic cores applied can be improved largely, electronic products are made to be smaller and more efficient, and effective help is provided for adjustment of the national industrial structure, energy conservation and emission reduction.