The invention discloses a large material plate replacing device. The large material plate replacing device comprises a rack, a feeding mechanism, a first air cylinder, a second air cylinder, a first pallet and a second pallet; and the feeding mechanism, the first air cylinder and the second air cylinder are all arranged on the rack, the first pallet is connected with the output end of the first air cylinder, the second pallet is connected with the output end of the second air cylinder, and the first pallet and the second pallet can alternately move to a feeding area. According to the large material plate replacing device, the first air cylinder can drive a material plate on the first pallet to move, the second air cylinder can drive a material plate on the second pallet to move, the firstair cylinder and the second air cylinder can alternately convey the material plates responsible respectively to the feeding area, and the two material plates can be automatically replaced. The large material plate replacing device is suitable for large material plates, especially large blister plates, and is also suitable for soft material plates; and according to the large material plate replacing device, the structure is simple and practical, the space is saved, the manufacturing cost is low, the plates are not clamped, sticking is avoided, operation is smooth and stable, and labor and the workload of starting personnel are reduced.