38results about How to "Increased selective inhibition" patented technology

The present invention provides a compound of formula (I) or the salt thereof:wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(═O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.

The invention discloses a device for autotrophic nitrogen removal of a composite biological membrane and an operation method. The device comprises a water inlet tank, an anoxic reactor, a first aerobic reactor, a second aerobic reactor, a third aerobic reactor, a fourth aerobic reactor and a settling pond which are communicated in sequence, wherein the inlet water in the water inlet tank is in communication with digested sludge dehydrating liquid of an urban sewage treatment plant, and the outlet water is in communication with the anoxic reactor; a sludge discharging pipe and a valve are arranged at the bottom part of the settling pond and are communicated with a sludge return pump and the anoxic reactor; a stirring device is arranged in the anoxic reactor; fixed fillers and aerating heads communicated with air compressors are placed in the first aerobic reactor, the second aerobic reactor, the third aerobic reactor and the fourth aerobic reactor; and a clean water overflowing port is formed in the settling pond. The operation method comprises the following steps: 1) inoculating sludge, culturing, and accessing an active sludge adaptive phase; 2) starting short-term nitratlon reaction; 3) implementing anaerobic ammonia oxidation; and 4) accessing a short-term nitration-anaerobic ammonia oxidation smooth operating phase. The device is applicable to denitriding of high-ammonia nitrogen sludge dehydrating solution in sewage treatment, and is perfect in structure, simple in operation, high in denitriding effect, and low in energy consumption.

The invention discloses a carbon inhibiting agent in a copper sulfide ore flotation process and application thereof, and belongs to the technical field of application of nonferrous metal flotation reagents. The inhibiting agent is formed by using derivatives of anthraquinone as carbon loving radicals and using polyoxyethylene ether as hydrophilic groups. Through application of the inhibiting agent, in copper sulfide ore flotation, carbon in ores can be effectively inhibited, so that the consumption of carbon impurities to a capturing agent is reduced, the flotation capturing of copper sulfide ores is facilitated, and the beneficiation index of copper concentrates is improved.

The invention discloses a novel inhibitor for aluminosilicate minerals and a use method of the novel inhibitor. The novel inhibitor is organic composite phosphate mainly composed of amino trimethylene potassium phosphate of the small molecular weight or amino trimethylene sodium phosphate of the small molecular weight. The use method of the novel inhibitor includes the steps that when positive flotation is conducted on bauxite, the granualarity property of a bauxite grinding product with the alumina-silica ratio ranging from 3 to 5 is -0.074 mm, and the size fraction accounts for 80% to 90%; and the pH value of a flotation system is controlled from 9 to 11, sodium oleate serves as a collecting agent, and the use amount ranges from 500 g / t to 1200 g / t. The use amount of the inhibitor ranges from 60 g / t to 70 g / t. The novel inhibitor is applied to the bauxite positive-flotation desilicication process, the selective inhibition effect on minerals containing silicon can be enhanced, meanwhile the capacity of eliminating unavoidable ions such as Ca2+ and Mg2+ can be enhanced, and the effect of positive flotation of the bauxite is improved.

The invention discloses a mineral processing method of carbon-containing lead-zinc sulfide ore, belonging to the technical field of mineral processing, comprising the following steps: (1) grinding raw ore to obtain a predetermined fineness of pulp; (2) adding the mineral pulp to the ground pulp Add carbon inhibitor, stir evenly, obtain the ore pulp after pulping; (3) add collector, foaming agent to carry out lead flotation in the pulp after pulping, obtain lead concentrate and lead flotation tailings; ( 4) Add carbon inhibitor to lead flotation tailings, carry out zinc flotation, and obtain zinc concentrate and tailings. The invention provides a mineral processing method of carbon-containing lead-zinc sulfide ore. The inhibitor used has a highly selective inhibitory effect, and can efficiently select and suppress carbon-containing impurities in the flotation of lead sulfide and zinc, so as to facilitate the efficient enrichment of lead sulfide and zinc. collection recycling.

The present invention provides one kind of phenoxy indenone compound. Pharmacological experiment shows that the compound may be used as acetylcholinesterase inhibitor and can competitively inhibit the activity of acetylcholine, delay the hydrolysis of acetylcholine and thus raise the synapse effect of acetylcholine. The compound may be used in preparing medicine for treating presenile dementia. The present invention has easy to obtain material, has mild reaction condition, high yield, simple operation and low production cost, and is suitable for industrial production.

The invention relates to a composition for killing Hela cancer cells. The composition is composed of ergosterol peroxide and paclitaxel, and has the effect of synergistically inhibiting the proliferation of Hela cancer cells, especially in the concentration range of 6.25-12.5 μg / ml ergosterol peroxide: 0.025-0.1 μg / ml paclitaxel. significantly. The composition can greatly reduce the dosage of paclitaxel, reduce cost and side effects, and may be effective for cancer cell lines resistant to paclitaxel.

The invention discloses a regulator for bauxite forward flotation and an application method of the regulator. The regulator is one kind of modified phosphate and mainly comprises 1-hydroxy ethylidene-1,1-diphosphonic acid potassium or 1-hydroxy ethylidene-1,1-diphosphonic acid sodium. The application method comprises the steps that when bauxite forward flotation is carried out, for bauxite with the alumina-silica ratio of 3:5, the granularity property of ore grinding products is -0.074 mm, the granulometric class is 80%-90%, the pH value of a flotation system is controlled to be 9-11, sodium oleate is adopted as a collecting agent, the use amount is 500-1,200 g / t, and the use amount of the regulator is 60-70 g / t. The regulator is applied to a bauxite forward flotation and desilicication technology, and the selective inhibition function on silicon containing ore can be enhanced; and meanwhile the elimination capacity on unavoidable ions (such as Ca2+ and Mg2+) is improved, and the effect of bauxite forward flotation is improved.