38results about How to "Increased selective inhibition" patented technology

The present invention provides a compound of formula (I) or the salt thereof:wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(═O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.

The invention discloses a gangue inhibitor and a beneficiation method of copper sulphide ore containing easily floated gangue minerals, belongs to the technical field of flotation, and solves the problem that gangue minerals have very adverse effects on flotation of copper sulphide ore. The gangue inhibitor comprises sodium polyacrylate, carboxymethyl cellulose, Arabic gum, sodium silicate, sodiumtripolyphosphate, anhydrous sodium sulfite, sodium lignosulfonate and anhydrous zinc sulfate. The method comprises the following steps: adding lime for ore grinding, and adding water for size mixing;sequentially adding a collecting foaming agent, an auxiliary collecting agent and a collecting agent into obtained ore pulp for roughing; adding a collecting agent into obtained roughing tailings, and scavenging for the first time; adding a collecting agent into the scavenging tailings, and carrying out secondary scavenging; sequentially adding pH regulator lime and the gangue inhibitor into an obtained roughing concentrate, and carrying out primary concentration; and adding pH regulator lime into an obtained primary concentration concentrate for secondary concentration. The gangue inhibitoris capable of reducing the floatability of gangue minerals greatly; the method is capable of improving the copper grade and the copper recovery rate of rough concentrate.

The invention discloses a beneficiation method for improving comprehensive recovery indexes of complex low-grade molybdenum polymetallic ores, and particularly relates to comprehensive recovery of valuable elements such as molybdenum, copper and sulfur in low-grade molybdenum ores. According to the method, the effective flotation separation of molybdenite, chalcopyrite and pyrite can be realized,and the comprehensive recovery indexes of the low-grade molybdenum ores are improved. The method comprises the following steps of primary ore grinding, molybdenum (molybdenite) flotation, secondary ore grinding (rough molybdenum copper concentrate regrinding), copper (chalcopyrite) flotation, and sulfur (pyrite) flotation. The method is stable and effective in reagent regime and beneficiation process flow and high in adaptability. By using the beneficiation method, high-quality molybdenite, chalcopyrite and pyrite are obtained from the complex, difficult-to-select and low-grade molybdenum polymetallic ore with associated copper / sulfur, and the comprehensive recovery indexes of sulfide minerals are excellent. The adopted reagent is non-toxic and harmless, has little influence on the environment, and is an excellent beneficiation method.

The present invention provides one kind of phenoxy indenone compound. Pharmacological experiment shows that the compound may be used as acetylcholinesterase inhibitor and can competitively inhibit the activity of acetylcholine, delay the hydrolysis of acetylcholine and thus raise the synapse effect of acetylcholine. The compound may be used in preparing medicine for treating presenile dementia. The present invention has easy to obtain material, has mild reaction condition, high yield, simple operation and low production cost, and is suitable for industrial production.

The invention relates to the technical field of beneficiation, in particular to a beneficiation method for high calcium carbonate type fluorite. The beneficiation method for high calcium carbonate type fluorite comprises the following steps of raw material grinding, rough concentrate preparing, a fifth fine selection process a sixth fine selection process. According to the beneficiation method for high calcium carbonate type fluorite, the heterogeneity of mineral surfaces and the interaction among various agents are utilized to improve the selective inhibition of the agents on calcium carbonate, so that effects of effectively inhibiting calcium carbonate and ensuring the recovery rate of fluorite are achieved; meanwhile by means of acidified water glass, pyrogallic acid, sodium hexametaphosphate, starch and the like, a synergistic effect can be produced, the flotation effect can be improved, and high-quality fluorite concentrate can be obtained; the beneficiation method for high calcium carbonate type fluorite has prominently substantial features and remarkable progress.

The invention discloses an inhibiting agent capable of selectively inhibiting calcium-containing gangue minerals in scheelite ores, and belongs to the technical field of mineral processing engineering. The inhibiting agent is formed by reacting the mixture of metal salt 80 percent-90 percent and polycarboxylate compounds 10 percent-20 percent. As metal ions have a selective activation effect on the calcium active points of the calcium-containing minerals, the selective inhibition effect on the calcium-containing gangue minerals by the polycarboxylate compounds is enhanced, and the effect of the inhibiting agent is improved. The inhibiting agent can be used in ore slurry at normal temperature, the usage amount of the inhibiting agent ranges from 200 g / t to 300 g / t, and the inhibiting agent is suitable for recovering scheelite from ores by selectively inhibiting the calcium-containing gangue minerals such as fluorspar and calcite when scheelite gangue minerals are mainly the calcium-containing minerals (the fluorspar and the calcite).

The invention discloses a flotation separation agent system for copper-molybdenum mixed concentrates and application of the flotation separation agent system. The flotation separation agent system forthe copper-molybdenum mixed concentrates comprises a copper mineral inhibitor, a molybdenum mineral collector and a foaming agent in a copper-molybdenum flotation separation process. The copper mineral inhibitor comprises the following components in parts by weight: 3-7 parts of sodium hydroxide, 3-6 parts of hydrogen peroxide, 15-25 parts of sodium thioglycolate, 2-5 parts of pentasodium diethylenetriaminepentaacetate and a proper amount of water; the molybdenum mineral collector comprises the following components in parts by weight: 20-30 parts of kerosene and 5-10 parts of tert-dodecyl mercaptan; and the foaming agent is 2-hexanol. The inhibitor and the collector are high in selective adsorption capacity, the synergy performance is excellent, the activity of groups of the foaming agentis high, formed foams are crisp and compact, and the mineralization effect is good. According to the flotation separation agent system for copper and molybdenum, the floatability difference between molybdenum minerals and copper minerals in the complex copper and molybdenum mixed concentrates difficult to separate can be greatly improved, the mutual content of the copper and the molybdenum is effectively reduced, the separation index is excellent, adopted agents are nontoxic and harmless, and the influence on the environment is small.

The invention discloses a beneficiation process of medium and low grade mixed collophanite. The beneficiation process comprises the following steps: S1, performing crushing; S2, screening the crushedores to obtain fine-grained ores and coarse-grained ores with different gradations; S3, respectively carrying out photoelectric separation on the coarse-grained ores with different gradations to obtain respective photoelectric separation concentrates and photoelectric separation tailings with different gradations; S4, respectively returning the photoelectric separation tailings with different particle sizes to the step S3, and repeating the steps until the P2O5 grade in the photoelectric separation tailings is less than or equal to 10%; S5, combining all the obtained photoelectric separation concentrates to obtain pre-enriched concentrates; S6, combining and grinding the fine-grained ores and the pre-enriched concentrates to obtain ore pulp to be separated; and S7, adding water into the ore pulp to be separated to obtain flotation ore pulp, and adopting flotation operation of one roughing, one refining and one scavenging so as to obtain final phosphate concentrates and final tailings.By means of silicon reduction through photoelectric separation and magnesium removal through single reverse flotation, the effects of high beneficiation efficiency, small floating ore amount, low energy consumption, low cost and environmental protection are achieved.

The invention relates to a beneficiation method for mixed refractory tungsten ore. The beneficiation method comprises the following steps: (1) grinding crushed raw ore of scheelite and wolframite paragenic ore to obtain ore pulp; (2) when the pH value of the ore pulp is 7.0-9.0, an inhibitor, adding an activating agent lead nitrate and a collecting agent for mixed tungsten roughing, and respectively obtaining tungsten rough concentrate ore pulp and roughing tailing ore pulp; (3) performing mixed tungsten scavenging operation on the roughing tailing ore pulp twice to obtain tungsten scavenging tailings I; (4) carrying out weak magnetic iron removal operation on the tungsten rough concentrate ore pulp to respectively obtain a magnetic iron product and magnetic separation tailing ore pulp; (5) carrying out strong magnetic roughing and scavenging on the magnetic separation tailing ore pulp to respectively obtain a wolframite concentrate product and scavenging operation tailings; (6) performing dense dehydration on the scavenging operation tailings, and obtaining ore pulp with the concentration being 60%-70%; and (7) carrying out concentrated scheelite flotation operation on 60%-70% of ore pulp to respectively obtain scheelite concentrate and tungsten scavenging tailings II. The method provided by the invention effectively realizes effective separation and enrichment of wolframite and scheelite.

The invention discloses a flotation separation method of talcum and copper pyrite. The method firstly adopts combination of three drugs carboxymethyl cellucose, CTP and calcium lignosulfonate as an inhibitor to carry out flotation separation on the talcum and the copper pyrite, the efficient selective inhibition effect on the talcum is possessed, meanwhile, clay mineral and copper pyrite particlescan be effectively dispersed, and the foam mixing phenomenon of hydrophilic gangue minerals is obstructed. The inevitable adverse effect of ions in ore pulp is eliminated, the selective inhibition effect of the inhibitor is further reinforced, gangue minerals such as the talcum and chlorite floating easily are selectively inhibited, thus flotation separation of the minerals is benefitted, the grade and the recycling rate of copper concentrate are improved, and the indicators in beneficiation are increased substantially. According to the method, the combined inhibitor is compared with a conventional talcum inhibitor, the three drugs collaborate, and have dual attributes of inhibitive ability and dispersity, the indicators in beneficiation of copper can be increased substantially, and the market application value is possessed.

The invention discloses carbon inhibitor used in copper sulfide ore flotation and application of the carbon inhibitor, and belongs to the technical field of nonferrous metal flotation reagent application. The inhibitor is composed in the manner that the ramification of biphenyl serves as a carbophile group, and polyoxyethylene ether serves as a hydrophilic group. Through usage of the inhibitor, during copper sulfide ore flotation, carbon in the ore can be effectively restrained, consumption of carbon impurities to a collecting agent is reduced, flotation collecting of the copper sulfide ore is facilitated, and the beneficiation index of copper concentrates is improved.

The invention relates to the technical field of beneficiation, in particular to a beneficiation method for high calcium carbonate type fluorite. The beneficiation method for high calcium carbonate type fluorite comprises the following steps of raw material grinding, rough concentrate preparing, a fifth fine selection process a sixth fine selection process. According to the beneficiation method for high calcium carbonate type fluorite, the heterogeneity of mineral surfaces and the interaction among various agents are utilized to improve the selective inhibition of the agents on calcium carbonate, so that effects of effectively inhibiting calcium carbonate and ensuring the recovery rate of fluorite are achieved; meanwhile by means of acidified water glass, pyrogallic acid, sodium hexametaphosphate, starch and the like, a synergistic effect can be produced, the flotation effect can be improved, and high-quality fluorite concentrate can be obtained; the beneficiation method for high calcium carbonate type fluorite has prominently substantial features and remarkable progress.

The invention discloses a regulator for direct flotation of diasporic bauxite and a using method thereof. The regulator is synthetic polycarboxylate, wherein a main component of the synthetic polycarboxylate is small-molecular-weight sodium polyacrylate (potassium polyacrylate). The using method of the regulator is that a bauxite grinding product with the alumina-silica ratio 3-5 and the particle size -0.074mm accounts for 80-90% when the direct flotation of the bauxite is performed, a potential of hydrogen (pH) value of a flotation system is controlled to be 9-11, the using amount of sodium oleate serving as collecting agent is 500-800g / t, and the using amount of the regulator is 60-80g / t. The regulator is applied to a bauxite direct-flotation desilicication process, the selective inhibition effect on silicon-contained ores can be enhanced, meanwhile the unavoidable ion (Ca2+, Mg2+ and the like) eliminating capacity is enhanced, and the bauxite direct flotation effect is improved.

The invention discloses a direct flotation regulator for collophanite containing high-power semi-oxide. The main component of the direct flotation regulator is polyacrylamide-p-methylstyryl hydroxamicacid salt. The invention further discloses a direct flotation method for the collophanite containing high-power semi-oxide. The fineness of an ore grinding product is controlled to be-0.074 mm, the grain size fraction accounts for 85%-97% through ore grinding operation, the pH of a flotation system is controlled to be 9-11, a pH regulator, the regulator, inhibitor sodium silicate and collecting agent unsaturated fatty acid are sequentially added, and after size mixing, the ore grinding product enters a direct flotation tank to be subjected to direct flotation desilication operation. The invention also discloses an application of the polyacrylamide-p-methylstyryl hydroxamic acid salt. The method is applied to the direct flotation process of collophanite containing high-power semi-oxide, the selective inhibition effect on fine-fraction silicon-containing minerals can be enhanced, meanwhile, the influence of Ca < 2 + > and Mg < 2 + > on the collecting agent can be eliminated to a certainextent, and the direct flotation effect of collophanite is improved.

The invention discloses a flavonoid derivative, which has structure formulas shown as a general formula (I) and a general formula (II) as in the description, wherein R1 is alkyl or cyclo alkane; R2 isalkyl or cyclo alkane; R1, R2 and nitrogen atoms form cycloaliphatic ring or heterocycle; R3 is alkyl or aryl or aralkyl; the value of n is 1 to 10. The invention also discloses a preparation methodand an identification method of the flavonoid derivative.

The invention discloses a carbon inhibitor in a lead-zinc sulfide ore flotation process and application thereof, and belongs to the field of sulfide ore flotation reagents. The structural formula of the carbon inhibitor is shown as the specification, wherein R is an oxygen-containing hydrophilic group, and n is 4-10. The carbon inhibitor provided by the invention takes nonylphenol as a carbon-philic group and uses polyoxyethylene ether and sulfo / carboxymethyl as hydrophilic groups, can effectively inhibit flotation of carbon when used for flotation of carbonaceous lead-zinc sulfide ore, the consumption of a collecting agent by carbon impurities is reduced, the carbon content in concentrate products is reduced, and the beneficiation index of lead-zinc concentrate is favorably improved.

The invention discloses a device for autotrophic nitrogen removal of a composite biological membrane and an operation method. The device comprises a water inlet tank, an anoxic reactor, a first aerobic reactor, a second aerobic reactor, a third aerobic reactor, a fourth aerobic reactor and a settling pond which are communicated in sequence, wherein the inlet water in the water inlet tank is in communication with digested sludge dehydrating liquid of an urban sewage treatment plant, and the outlet water is in communication with the anoxic reactor; a sludge discharging pipe and a valve are arranged at the bottom part of the settling pond and are communicated with a sludge return pump and the anoxic reactor; a stirring device is arranged in the anoxic reactor; fixed fillers and aerating heads communicated with air compressors are placed in the first aerobic reactor, the second aerobic reactor, the third aerobic reactor and the fourth aerobic reactor; and a clean water overflowing port is formed in the settling pond. The operation method comprises the following steps: 1) inoculating sludge, culturing, and accessing an active sludge adaptive phase; 2) starting short-term nitratlon reaction; 3) implementing anaerobic ammonia oxidation; and 4) accessing a short-term nitration-anaerobic ammonia oxidation smooth operating phase. The device is applicable to denitriding of high-ammonia nitrogen sludge dehydrating solution in sewage treatment, and is perfect in structure, simple in operation, high in denitriding effect, and low in energy consumption.

The invention discloses a regulator for bauxite forward flotation and an application method of the regulator. The regulator is one kind of modified phosphate and mainly comprises 1-hydroxy ethylidene-1,1-diphosphonic acid potassium or 1-hydroxy ethylidene-1,1-diphosphonic acid sodium. The application method comprises the steps that when bauxite forward flotation is carried out, for bauxite with the alumina-silica ratio of 3:5, the granularity property of ore grinding products is -0.074 mm, the granulometric class is 80%-90%, the pH value of a flotation system is controlled to be 9-11, sodium oleate is adopted as a collecting agent, the use amount is 500-1,200 g / t, and the use amount of the regulator is 60-70 g / t. The regulator is applied to a bauxite forward flotation and desilicication technology, and the selective inhibition function on silicon containing ore can be enhanced; and meanwhile the elimination capacity on unavoidable ions (such as Ca2+ and Mg2+) is improved, and the effect of bauxite forward flotation is improved.

The present invention provides a compound of formula (I) or the salt thereof:wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(═O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.

The invention discloses a carbon inhibiting agent in a copper sulfide ore flotation process and application thereof, and belongs to the technical field of application of nonferrous metal flotation reagents. The inhibiting agent is formed by using derivatives of anthraquinone as carbon loving radicals and using polyoxyethylene ether as hydrophilic groups. Through application of the inhibiting agent, in copper sulfide ore flotation, carbon in ores can be effectively inhibited, so that the consumption of carbon impurities to a capturing agent is reduced, the flotation capturing of copper sulfide ores is facilitated, and the beneficiation index of copper concentrates is improved.

The invention discloses a carbon inhibitor in the flotation process of sulfide lead-zinc ore and its application, and belongs to the field of flotation agents for sulfide ore. The structural formula of the carbon inhibitor is as follows: wherein, R is an oxygen-containing hydrophilic group, n The value ranges from 4 to 10. The carbon depressant provided by the present invention uses nonylphenol as the carbophilic group, and polyoxyethylene ether and sulfonic acid group / carboxymethyl group as the hydrophilic group. During the flotation of carbonaceous lead-zinc ore, the The use of inhibitors can effectively inhibit the flotation of carbon, reduce the consumption of collectors by carbon impurities, reduce the carbon content in concentrate products, and help improve the beneficiation index of lead-zinc concentrate.

The invention discloses a regulator for direct flotation of diasporic bauxite and a using method thereof. The regulator is synthetic polycarboxylate, wherein a main component of the synthetic polycarboxylate is small-molecular-weight sodium polyacrylate (potassium polyacrylate). The using method of the regulator is that a bauxite grinding product with the alumina-silica ratio 3-5 and the particle size -0.074mm accounts for 80-90% when the direct flotation of the bauxite is performed, a potential of hydrogen (pH) value of a flotation system is controlled to be 9-11, the using amount of sodium oleate serving as collecting agent is 500-800g / t, and the using amount of the regulator is 60-80g / t. The regulator is applied to a bauxite direct-flotation desilicication process, the selective inhibition effect on silicon-contained ores can be enhanced, meanwhile the unavoidable ion (Ca2+, Mg2+ and the like) eliminating capacity is enhanced, and the bauxite direct flotation effect is improved.

The present invention provides one kind of phenoxy indenone compound. Pharmacological experiment shows that the compound may be used as acetylcholinesterase inhibitor and can competitively inhibit the activity of acetylcholine, delay the hydrolysis of acetylcholine and thus raise the synapse effect of acetylcholine. The compound may be used in preparing medicine for treating presenile dementia. The present invention has easy to obtain material, has mild reaction condition, high yield, simple operation and low production cost, and is suitable for industrial production.

The invention relates to a composition for killing Hela cancer cells. The composition is composed of ergosterol peroxide and paclitaxel, and has the effect of synergistically inhibiting the proliferation of Hela cancer cells, especially in the concentration range of 6.25-12.5 μg / ml ergosterol peroxide: 0.025-0.1 μg / ml paclitaxel. significantly. The composition can greatly reduce the dosage of paclitaxel, reduce cost and side effects, and may be effective for cancer cell lines resistant to paclitaxel.

The invention discloses a flavonoid derivative, which has structure formulas shown as a general formula (I) and a general formula (II) as in the description, wherein R1 is alkyl or cyclo alkane; R2 isalkyl or cyclo alkane; R1, R2 and nitrogen atoms form cycloaliphatic ring or heterocycle; R3 is alkyl or aryl or aralkyl; the value of n is 1 to 10. The invention also discloses a preparation methodand an identification method of the flavonoid derivative.

The invention discloses a regulator for bauxite forward flotation and an application method of the regulator. The regulator is one kind of modified phosphate and mainly comprises 1-hydroxy ethylidene-1,1-diphosphonic acid potassium or 1-hydroxy ethylidene-1,1-diphosphonic acid sodium. The application method comprises the steps that when bauxite forward flotation is carried out, for bauxite with the alumina-silica ratio of 3:5, the granularity property of ore grinding products is -0.074 mm, the granulometric class is 80%-90%, the pH value of a flotation system is controlled to be 9-11, sodium oleate is adopted as a collecting agent, the use amount is 500-1,200 g / t, and the use amount of the regulator is 60-70 g / t. The regulator is applied to a bauxite forward flotation and desilicication technology, and the selective inhibition function on silicon containing ore can be enhanced; and meanwhile the elimination capacity on unavoidable ions (such as Ca2+ and Mg2+) is improved, and the effect of bauxite forward flotation is improved.

The invention relates to the technical field of collophosite mineral processing, and discloses a medium-low grade mixed type collophanite flotation separation agent system and its application, the flotation separation agent system includes inhibitors and collectors; by weight parts , the inhibitor includes 4 to 6 parts of sodium tripolyphosphate, 2 to 3 parts of hexametaphosphate and 2 to 3 parts of phosphoric acid, and the collector includes 4 to 5 parts of sodium vegetable oil and dodecyl phosphoric acid 1 part of ester; the preparation method of the collector is to add NaOH solution into the mixed solution of vegetable oil and dodecyl phosphate, and react by heating; the vegetable oil includes cottonseed oil, rice bran oil, At least one of castor oil, corn oil and soybean oil; the present invention increases the selective inhibition of the inhibitor on apatite minerals in the flotation pulp by adding phosphates with a high degree of polymerization in the inhibitor function, so that the collector molecules are more effectively adsorbed on the surface of calcium magnesium minerals, and the effect of effectively improving the sorting property of apatite minerals is achieved.

The invention discloses a beneficiation method for carbon-containing lead-zinc sulfide ore, which belongs to the technical field of beneficiation. The method comprises the following steps: (1) grinding raw ore to obtain ore pulp with preset fineness; (2) adding a carbon inhibitor into the ore pulp subjected to ore grinding, and uniformly stirring to obtain ore pulp subjected to pulp mixing; (3) adding a collecting agent and a foaming agent into the pulp obtained after pulp mixing for lead flotation to obtain lead concentrate and lead flotation tailings; and (4) adding a carbon inhibitor into the lead flotation tailings, and carrying out zinc flotation to obtain zinc concentrate and tailings. According to the beneficiation method for the carbon-containing lead-zinc sulfide ore, the adoptedinhibitor has a high-selectivity inhibition effect, carbon-containing impurities can be efficiently selected and inhibited in lead and zinc sulfide flotation, and efficient enrichment and recovery oflead and zinc sulfide are conveniently achieved.