The invention relates to an electricity, heat and gas coupling park comprehensive energy system operation optimization method considering multiple energy flows of a network. The method comprises the steps of 1, carrying out mathematical modeling of a power distribution network; 2, carrying out mathematical modeling of the natural gas pipeline network; 3, carrying out mathematical modeling of the heat supply pipe network; 4, modeling the external characteristics of the energy supply equipment; 5, constructing a mathematical optimization problem; and 6, solving an optimization problem. The system has the beneficial effects that 1, coordinated optimization of three energy systems including electric power, natural gas and thermal power of the park comprehensive energy system can be achieved; 2, the method provided by the invention can calculate network details (reactive power in a power grid, node voltage, node air pressure in a natural gas system, pipeline airflow, return water temperature in a thermodynamic system, water pump power and the like) of each energy system, and analyzes the influence of the equipment access position on the system;.