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A vertical off-line stand building system includes a mast having a basal portion and an upper portion. An upper pipe elevator is mounted in the upper portion of the mast and is selectively translatable by a selecting actuable first hoist between upper raised and lowered positions. A lower pipe elevator is mounted in the basal portion of the mast and is selectively translatable by a selecting actuable second hoist between basal raised and lowered positions. A horizontal pipe support table is positioned adjacent the base of the mast. A horizontal pipe translator is mounted in the table for translating a pipe single longitudinally along the table so as to engage a first end of the pipe single with the lower pipe elevator when in its basal lowered position. The lower pipe elevator draws the first pipe into the mast through a front opening in the mast. The upper pipe elevator takes the first pipe and elevates it to the top of the mast. The lower pipe elevator raises the next pipe into the mast which is then threaded to the first pipe and the pipe stand then elevated by the upper pipe elevator so that the lower pipe elevator may add successive pipes to the pipe stand. The rear of the mast is entirely open so that the assembled pipe stand may be removed.

A mutant prourokinase plasminogen activator (M5) was developed to make prouPA less subject to spontaneous activation during fibrinolysis. C1-inhibitor complexes with tcM5. The effect of C1-inhibitor on fibrinolysis and fibrinogenolysis by M5 was determined. Supplemental C1-inhibitor restores the stability of M5 but not that of prouPA. Clot lysis by M5 with supplemental C1-inhibitor showed no attenuation of the rate of fibrinolysis, whereas fibrinogenolysis was prevented by C1-inhibitor. Due to higher dose tolerance of M5 with C1-inhibitor, the rate of fibrin-specific lysis reached that achievable by nonspecific fibrinolysis without inhibitor. Plasma C1-inhibitor stabilized M5 in plasma by inhibiting tcM5 and thereby non-specific plasminogen activation. At the same time, fibrin-specific plasminogen activation remained unimpaired. This unusual dissociation of effects has significant implications for improving the safety and efficacy of fibrinolysis. Methods of reducing bleeding and non-specific plasminogen activation during fibrinolysis by administering M5 along with exogenous C1-inhibitor are disclosed.

Catalytic partial oxidation using a metal oxide catalyst surface treats crumb rubber that is recovered from waste rubber tires. Advantages of using catalytically oxidized crumb rubber relative to using non-catalytically oxidized crumb rubber in making the rubberized concrete, includes superior mechanical strength and water-repealing capability, lower oxidation temperature and shorter oxidation time, and accelerated hydration times. Rubber oil (a gas condensate) co-produced from the crumb rubber partial oxidation process is equal to or better than the commercial superplasticizers. Industrial scale partial oxidation employs a continuous flow tubular reactor where a crumb rubber / catalyst mixture is fed into the reactor co-currently with an air / nitrogen mixture.

Disclosed herein are methods of using an immobilized substrate, immobilized ligand, and a fusion protein of an enzyme for the substrate and a receptor for the ligand, where the immobilized substrate can react to form an immobilized product that has a different mass than the immobilized substrate, and using this transformation to indirectly determine the binding of the receptor and the ligand. These methods can be used for high-throughput screening for possible modulators (e.g., inhibitors or activators) of the ligand-receptor interaction.