The invention belongs to the technical field of metal materials and machining thereof, discloses an Al-Zn-Mn alloy profile for a rail transit vehicle body and a preparation method thereof, and relatesto the technical field of aluminum alloy machining. The alloy comprises the following chemical components of, by mass, 4.4-4.6 % of Zn, 0.1-0.15% of Cu, 0.3-0.4% of Mn, 0.16-0.24% of Cr, 0.04-0.08% of Ti, 0.12-0.20 of Zr, less than or equal to 0.12% of Fe, less than or equal to 0.06% of Si, and the balance Al, wherein the ratio of the mass percentage of the Zn to the mass percentage of the Mg is3.2 to 3.5. The Al-Zn-Mn alloy material prepared through the preparation method has high toughness, corrosion resistance, anti-fatigue and weldable characteristics, and can meet the running requirements of the high-speed rail transit vehicle body.