The utility model relates to a fast-clamping and self-aligning grinding wheel flange for a precision grinding machine, which relates to the field of precision grinding. Equipped with machine tool spindle, grinding wheel fixing nut, grinding wheel, self-aligning wrench, jaws, back end of centering device back cover, small bevel gear, front end of centering device back cover, centering device front cover, ball cover, bearing, large cone Gears and balls; first, install the statically balanced grinding wheel flange into the taper front end of the machine tool spindle, and pre-tighten it with the grinding wheel fixing nut, then insert the self-aligning wrench into the self-aligning hole of the flange, and the self-aligning wrench passes through the small bevel gear and The gear transmission of the large bevel gear drives the large bevel gear to rotate. At the same time, the feed movement of the claw is realized through the rack transmission between the plane thread on the large bevel gear and the claw. The claw that moves in three directions at the same time grasps the machine tool spindle to solve The problem of eccentricity between the center of the grinding wheel and the axis of the machine tool spindle is solved. The structure is simple, economical and reliable, and the clamping of the grinding wheel is realized; the eccentricity error in the assembly of the grinding wheel is effectively overcome.