The invention discloses a large-dose powder packaging machine. The machine comprises a fixing frame, a conveying belt, a first guide plate, a second guide plate, an adjusting frame, a guide groove anda sewing and packaging machine. When the large-dose powder packaging machine is used, the adjusting frame is first pulled, the two ends of the adjusting frame slide in a sleeve, so that the height ofthe guide groove is adjusted, when the height of the guide groove is flush with the upper portion of a packaging bag, a first fixed handle is rotated, so that the first fixed handle contacts with theouter wall of the adjusting frame, the position relationship between the adjusting frame and the sleeve is fixed, then the height of a lantern ring on a third supporting frame is adjusted, the lantern ring drives the sewing and packaging machine to ascend and descend through a cross rod, finally, the sewing and packaging machine corresponds to a sewn mouth of the packaging bag, then a second fixed handle is rotated, so that the second fixed handle touches the outer wall of the third supporting frame, the position relationship between the lantern ring and the third supporting frame is fixed, so that the height of the sewing and packaging machine is fixed, and device adjusting tooling is completed.