78 results about "CLASS AMPHIBIA" patented technology

In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans.

A reptile housing structure allows users to assemble by themselves. It includes a bottom chest for housing breeding reptiles and amphibians and required goods, three side panels and a face panel to be coupled on the bottom chest, and an upper lid coupled on the upper edges of the three side panels and the face panel. This invention uses a small size glass and may be disassembled and packaged. The glass is less likely to be broken, thus can save cost. The package size also is smaller, thus can save transportation space and reduce transportation cost.

The amphibian rolling car comprises the outside wall and inner cavity, a frame of a cylinder and edge bracket of two sides, wall plate at the edge frame to form a sealed cabin, a slide plate cart inside the cavity rotating with the roller coaxially, ring track inside the frame with the slide plate on the ring track. The slide plate car is electric driving or driven, with simple structure, small size, elegant in shape, being able to use on road, square, grass and snow and even in water.

An amphibian (10) capable of travel on land and on water is provided with a body and a planing hull (12), and three road wheels (20, 24) mounted on retractable suspension (22, 26) which may be protracted for road use, or retracted for use on water; and further comprises ride-on seating for at least one driver to sit astride the body. Marine propulsion is provided by at least two jet drives (30), which have intakes (32) and nozzles (34). Picture 3 shows a power train and retractable rear wheel suspension. Steering control may be by handlebars (42), or by a steering wheel (not shown). The jets may be driven by belts and / or driveshafts. A separate power source may be provided for marine use. A windscreen (44) may be fitted.

A retractable land propulsion assembly for an amphibian including a retraction linkage movable between a protracted position and a retracted position, an actuator for moving the retraction linkage between the protracted position and retracted position, and at least one wheel and / or track drive. When the retraction linkage is protracted then the retraction linkage supports and / or holds the at least one wheel and / or track drive in a ground engaging position for use on land. The retraction linkage comprises at least one component or part or portion thereof that passes through an overcentre position on protraction to prevent forces received in use via the at least one wheel and / or track drive from acting to retract the retraction linkage.

The invention discloses skin repair peptide cathelicidin-NV of nanorana pleskei as well as a gene and application thereof, and belongs to the field of biomedicines. The skin repair peptide cathelicidin-NV is a ring type polypeptide encoded by a defense peptide gene of nanorana ventripunctata which is a special species belongs to the Chinese amphibian; the molecular weight is 2845.9 Dalton, and theisoelectric point is 9.90; the amino acid sequence of the skin repair peptide cathelicidin-NV is shown in SEQ ID NO: 1. The gene GenBank accession No.(MH010580) for encoding a skin repair peptide cathelicidin-NV precursor comprises 652 nucleotide sequences, and each nucleotide sequence is shown in SEQ ID NO: 2; nucleotides at sites from 367 to 438 are encoding genes of the skin repair peptide cathelicidin-NV of the nanorana pleskei. The invention further discloses the application of the skin repair peptide cathelicidin-NV of the nanorana pleskei in preparation of a treatment drug for promoting skin wound repairing. The skin repair peptide cathelicidin-NV has the beneficial effect that the skin repair peptide cathelicidin-NV has a relatively strong effect of promoting wound healing of a skin wound, and the wound healing promoting effect of the skin repair peptide cathelicidin-NV is similar to that of an epidermal growth factor (EGF).

The invention discloses an amphibian bicycle which aims to solve the problems that a floating device of an existing amphibian bicycle occupies a large space when the amphibian bicycle is ridden on the land and the amphibian bicycle can not be braked on the water. The amphibian bicycle comprises a front wheel assembly, a rear wheel assembly, a floating device, a frame, a driving mechanism and a steering mechanism, wherein the front wheel assembly and the rear wheel assembly are respectively of a hubless structure, the floating device is connected with the interior of the front wheel assembly and the interior of the rear wheel assembly and provided with a folding stretching arm, a gear transmission mechanism of the driving mechanism is connected with a propeller driving assembly through a flexible shaft connecting mechanism and fixed to the frame, the propeller driving assembly is fixedly connected with the rear wheel assembly, a control part of the steering mechanism is assembled on the frame, and an execution part of the steering mechanism is assembled on the propeller driving assembly of the driving mechanism and connected with the control part through a pull rope.

Planing amphibian (10) comprises hull (12) and a pair of wheels (20) mounted on a retractable suspension assembly (22). At least one land drive and at least one separate marine drive (40) are provided. A wheel retraction mechanism is provided for moving the wheels between a deployed wheel position for use of the amphibian on land and a retracted wheel position above a waterline of the amphibian for planing on water. The suspension assembly comprises suspension arms (24) outside the pair of wheels (20) so that the wheels (20) lie between the arms (24). Marine drives (40) may be inboard of the wheels or outboard thereof. An axle (28) with a differential (29) may be provided. Suspension and retraction may be provided by means of torsion bars (30) with a cranked central section (54, 55).

The invention provides a novel efficient amphibian vehicle; two propelling devices at the rear end are of same structure and each includes a steering engine arranged in the vehicle, an inner disc connected with the output end of the steering engine, an outer disc arranged at the outer side of the inner disc, spokes, and a tire, the inner disc is provided with three inner disc spindles arranged evenly, the outer disc is provided with three outer disc sliding shafts arranged evenly, each spoke is of circular structure composed of three sub-hubs, the tire is also of circular structure composed of three sub-tires, the sub-hubs and the sub-tires form a deformable wheel, one end of each sub-hub is hinged to the corresponding inner disc spindle, the other end of the each sub-hub is connected to the corresponding sub-tire, each sub-hub is provided with a curvilinear shaft slot, and the corresponding outer disc sliding shaft is arranged in each curvilinear shaft slot. Through simple mechanical transmission, expected motion trajectories of the propelling devices are achieved; the novel efficient amphibian vehicle is easy to control.

The invention relates to the technical field of environment monitoring equipment, in particular to an amphibian unmanned aerial vehicle environment monitoring device. The device comprises an unmannedaerial vehicle body and a controller arranged inside the unmanned aerial vehicle body for controlling the unmanned aerial vehicle, further comprises a floating mechanism arranged at the bottom of theunmanned aerial vehicle body and for enabling the unmanned aerial vehicle body to float on the water surface, a detecting mechanism for detecting the water quality and a sampling mechanism for sampling water to be detected, and the detecting mechanism and the sampling mechanism are arranged on the floating mechanism. The monitoring device performs detecting and sampling more flexibly in the mode of the unmanned aerial vehicle.

The invention relates to an amphibian isolated heart perfusion device. The device comprises an arterial cannula, a venous cannula, a drip recording electrode and an electrocardio lead electrode, wherein the arterial cannula is formed by combining an arterial cannula trunk, an aorta inserting end and a liquid discharging pipe through a three-way valve; the venous cannula is formed by combining a liquid storage tank, a postcaval vein inserting end and a liquid adding pipe through a three-way valve, and parts of the arterial cannula and the venous cannula are inserted and combined into one. The drip recording electrode comprises a drip recording electrode head, a drip recording electrode rod and a signal input end; the electrocardio lead electrode comprises an electrocardio lead electrode head, an electrocardio lead electrode rod, a signal input end, a heart outer wall liquid adding pipe and a three-way valve. The multifunctional amphibian isolated heart perfusion device is suitable for one person to operate, facilitates perfusion liquid replacement, and is suitable for synchronously and dynamically detecting dynamical changes of the cardiac output, myocardial contraction tension, electrocardiogram and various cardiac function indexes.

Endogenously produced cationic antimicrobial peptides are ubiquitous components of host defenses in mammals, birds, amphibia, insects, and plants. Cationic peptides are also effective when administered as therapeutic agents. A practical drawback in cationic peptide therapy, however, is the cost of producing the agents. The methods described herein provide a means to efficiently produce cationic peptides from recombinant host cells. These recombinantly-produced cationic peptides can be rapidly purified from host cell proteins using anion exchange chromatography.

A hydraulic system for an amphibian provided with at least one retractable wheel or track drive, includes a first hydraulic circuit having at least one hydraulic actuator and associated controller for retracting and protracting the at least one wheel or track drive, a second hydraulic control having at least one hydraulic actuator and associated controller for providing hydraulic assist for steering and / or brake functions of the amphibian.

The invention belongs to the technical field of propellers and particularly relates to an integrated amphibian propeller. The integrated amphibian propeller comprises a duct, a propeller, a frame, a high-speed motor, an overrunning clutch and a low-speed motor, and the propeller, the frame, the high-speed motor, the overrunning clutch and the low-speed motor are arranged in the duct. The high-speed motor and the low-speed motor are mounted in the duct through the frame; the low-speed motor is connected with the high-speed motor through the overrunning clutch; the propeller is positioned at thefront end of the duct and arranged on an output shaft of the high-speed motor; front and rear ends of the duct are provided with a front flow guide cover and a rear flow guide cover. The integrated amphibian propeller is variable in output torque and rotating speed, realizes underwater and aerial propelling functions and has advantages of compact structure, light weight, high reliability and thelike.

Aquatect is an apparatus that consists of six building blocks that create a perfect, clean, and safe ecosystem for pets: herptiles (amphibians and reptiles), arthropods (spiders, insects, scorpions, and crustaceans), mollusks, and fish. The apparatus can be housed in aquarium tanks. The apparatus is constructed to replicate any ecosystem to accommodate any species listed above together or independently. The apparatus or blocks can also use different types of substrates to create various ecosystems. The ecosystem can be arid, tropical, humid, terrestrial, rocky, etc. to suit the needs of the species listed above. The ecosystem will be able to sustain life and suit the inhabitants. The apparatus or blocks are easily removable, and can be cleaned separately, so the ecosystem is not disturbed, or removed and cleaned all together. The blocks are not permanently adhered to the tank so they do not disrupt the integrity of the host tank. The apparatus is also unique because all the blocks work in union with each other and can be arranged in different configurations to create unique ecosystems. Aquatect gives a person total creativity to design a personal and unique ecosystem for their pet(s).

The present invention provides molecular tools for the visualization of the lymphatic vessel system in amphibian. Furthermore, the invention provides assays that allow screening for compounds able to modulate lymphangiogenesis.

The present invention involves an edible terrarium substrate for a terrarium animal such as a reptile, an amphibian, or an arachnid. The substrate includes a fine calciferous sand that is healthy, ingestible, and digestible by the terrarium animal.

The invention discloses an amphibian twin-hull hydrofoil sightseeing boat, wherein a submarine left demihull and a submarine right demihull which are parallel to each other and have the same size are connected with each other to form a boat body through a cross structure on the water surface; the boat bottom of the boat body is provided with front land wheels and rear land wheels; a front position and a rear position of the boat body are respectively provided with a front hydrofoil and a rear hydrofoil; a front hydrofoil strut is arranged on the front hydrofoil and connected with the left demihull and the right demihull; a rear hydrofoil strut is arranged on the rear hydrofoil and connected with the left demihull and the right demihull; one end of the rear hydrofoil strut is provided with a rotating shaft of the hydrofoil; and the front hydrofoil is provided with a foldable structure. Under the condition of high speed, the hydrofoils which are arranged on the boat generate the lift force; when the lift force is equal to the water discharge, the boat body is completely lifted out of the water surface and only the hydrofoils and the struts contact the water, thereby reducing the discharge volume of the boat body, greatly reducing the resistance, reducing the wetted surface area and achieving the aim of improving the speed of the boat; and the amphibian twin-hull hydrofoil sightseeing boat is an amphibian twin-hull hydrofoil boat which is suitable for sightseeing, entertainment and relaxation.

The invention discloses an amphibian, belonging to a traffic tool. The problems that the traditional vehicle is provided with a single function, and people can not self-rescue when suddenly encounter a rainstorm or a torrential flood are mainly solved by the amphibian. The amphibian comprises a car body, a compartment and floaters, the compartment which is concave inside the bottom and flat on the periphery is arranged in the backseat part of the car body, foldable and telescopic floaters are arranged on the left side, the right side and the back of the compartment, and after all the floaters are unfolded, the periphery of the compartment is surrounded. The amphibian has a simple structure, is safe and convenient to use, and is particularly suitable for application in an area with frequent occurrence of rainstorms and torrential floods and for an aquaculture farmer.

Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i.e., isolated or substantially pure) α subunits and β subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i.e., α1, α2 α3 α4 α5 α6 and / or α7 in combination with at least one of an α and β subunit are also provided. A recombinant, non-human cell line expressing the human α7 subunit of nAChR is disclosed.

The invention relates to an amphibian bicycle, in particular to a bicycle capable of realizing water running function. The main devices capable of realizing water running function are as follows: a floating device, a connecting rod supporting device, a cushion and a front flywheel linkage lifting device, a tap adjusting device, a hub paddle wheel pick driving device and a front wheel steering device, wherein floating bodies take the shape of dumbbells and are fixed with the connecting rod supporting device and symmetrically mounted on the two sides of the bicycle. When the bicycle runs on the land, the floating body can be picked up by the connecting rod supporting device and is clung to the two sides of the bicycle, so as to realize land cycling function of general bicycles; when the bicycle runs on the water, the connecting rod support device can be put down and the floating body is placed on the water surface, and meanwhile, the cushion and the front flywheel can be elevated through the cushion and the front flywheel linkage lifting device, so that foot wet or cloth wet caused by water cycling can be avoid. Water running steering can be realized by treading pedals, controlling the tap by hand, and swing a front solid wheel.

The invention discloses an amphibian dredging robot. The amphibian dredging robot comprises a robot body rack, a driving cab and an engine, wherein the driving cab is arranged on the robot body rack;a steering pedestal is arranged in the driving cab; a display is arranged on the steering pedestal; a microprocessor is arranged at the rear of the display; a control rod is arranged below the display; a steering wheel is arranged on one side of the control rod; a fixing key is arranged on one side of the steering wheel; a cooler is arranged at the rear of the driving cab; a distributing valve isarranged on the cooler; and a hydraulic pump is arranged on one side of the distributing valve. The amphibian dredging robot has the beneficial effects that a connecting pin penetrates through an excavator bucket and an excavator arm, the excavator bucket is conveniently to disassemble to change a reamer for dredging, meanwhile, the engine drives traveling crawlers to travel on a road surface, thewhole robot can conveniently walk onto a carrier vehicle, moreover, the robot travels in water by use of propelling blades, and is fixed by a pile leg and a stabilizing plate, and smooth dredging operation is ensured.

The invention relates to a rana nigromaculata antimicrobial peptide as well as a gene and application thereof, and belongs to the technical field of biomedicine. The rana nigromaculata antimicrobial peptide is a gene coded single-chain polypeptide separated from an amphibian rana nigromaculata of China, wherein the molecular weight is 1,647.02 Daltons, and the isoelectric point is 11.05; and the complete sequence of the rana nigromaculata antimicrobial peptide is phenylalanine-isoleucine-proline-leucine-valine-serine-glycine-leucine-phenylalanine-serine-arginine-leucine-leucine-glycine-lysine. The coded gene of the rana nigromaculata antimicrobial peptide consists of 316 nucleotides, wherein the mature coded part of the coded gene contains 142nd-186th nucleotides. The artificially synthesized rana nigromaculata antimicrobial peptide has a strong antibacterial effect, has the advantages of high safety, simple sequence and convenience in synthesis, and can be used as a novel anti-infective agent for application.

The invention provides an amphibian boat and a clutch accelerating device used by the amphibian boat in order to overcome the defects that a recreating and sporting article in the prior art is single in function, some recreating and sporting articles can only move on a water surface, some recreating and sporting articles can only walk on land, and operation is inconveniently performed. The clutch accelerating device comprises a clutch frame, an upper fan-shaped wheel, a lower fan-shaped wheel, an upper driving wheel and a lower driving wheel, wherein the clutch frame is positioned between the upper fan-shaped wheel and the lower fan-shaped wheel; the clutch frame, the upper fan-shaped wheel and the lower fan-shaped wheel are coaxially arranged on a main shaft I; the clutch frame is fixedly connected with the main shaft I; the upper fan-shaped wheel and the lower fan-shaped wheel are rotationally connected with the main shaft I respectively; the upper fan-shaped wheel is connected with the upper driving wheel in a meshing and driving way; the lower fan-shaped wheel is connected with the lower driving wheel in a meshing and driving way; the lower driving wheel and a gear I are coaxially and fixedly arranged on a swing rod shaft; the upper driving wheel and a gear II are coaxially and fixedly arranged on a driving shaft I; the gear I and the gear II are connected in a meshing and driving way. According to the clutch accelerating device provided by the invention, when a rocker rod shakes for one time, the swing rod shaft swings for two times, so that the speed is high, and labor is saved.

The invention provides an amphibian space changeable multifunction architecture capable of floating on water, being arranged on land and changing space of a building according to requirements of people to achieve functional change. The amphibian space changeable multifunction architecture comprises a relative fixed building, and is characterized in that a building of which the space is changeable is arranged in the building to realize changing the space of the building through reciprocating sliding of a track or a rolling wheel set. When combined with a buoying device base on water, the architecture can be used as a water architecture; when a building construction part is detached with the buoying device base, the building construction part can also be arranged on the land and the buoying device base is still arranged in the water; and partial space of the fixed building construction can be changed and displaced in three-dimensional space under the conditions of the water and the land so as to make the space of the positioned environment generate novel combined forms. The amphibian space changeable multifunction architecture can greatly relieve the strain situation that construction-using land for towns is increased day by day.