The invention discloses an anti-interference zero setting system, and belongs to the technical field of signal processing. The system comprises an antenna radiation unit, a receiving link, a digital array module and an adaptive beam forming module, wherein a spatial incoming wave signal is received by the antenna radiation unit, amplified and filtered by the receiving link and then sent to the digital array module to complete primary digital beam forming of multiple signals in a subarray, and finally, the adaptive beam forming module forms a zero setting beam and a static beam. According to the invention, through the dimension reduction two-stage beam forming architecture, the calculation amount of beam forming and the adaptive zero setting requirement are both considered. Besides, the optimized non-uniform subarray and layout arrangement are used, so that the sidelobe performance of a directional diagram is improved, and the grating lobe influence of zero-setting beam forming is reduced. The method can be realized on the basis of FPGA and SoC pipeline iterative loop architecture, so that the calculation amount of adaptive zero setting can be further reduced, and the real-time performance of interference signal detection is improved.