The invention discloses an Alzheimer's
disease diagnosis method based on a self-adaptive fine-grained causal
brain network, and relates to the field of
bioinformatics. The method mainly comprises four parts of adaptive fine-grained division, causal
brain network construction, causal network fusion based on intervention and
disease diagnosis based on the causal
brain network. The method comprises the following specific steps: firstly, finely dividing a brain network according to tense period difference of a
brain region by adopting a self-adaptive fine-grained division method, and capturing spatiotemporal characteristics of different scales; then, spatial-temporal features are extracted from the fine-grained partitions,
feature learning is performed by using
deep learning and a
frequency domain algorithm, and multi-
granularity feature representation of the brain network is obtained; and then, constructing a causal brain network by using a
causal inference technology, identifying a causal relationship between brain regions, and analyzing correlation between different brain regions. Furthermore, in combination with a causal intervention strategy, information of the brain-level causal network is integrated into the fine-grained causal network. And finally, by constructing a diagnosis model based on a fine-grained causal brain network, brain network features are classified by using a graph neural network, and early diagnosis of the Alzheimer's
disease is realized. The process allows a causal brain network to be constructed based on
brain region division, causal changes between brain regions are revealed, and the Alzheimer's disease diagnosis result is improved.