The invention discloses an anti-interference constant current LED driving circuit, which includes: a rectification filter circuit, a power supply circuit, a control module, a current regulation circuit, and a switch circuit. The control module includes: a constant current control unit, a state detection unit, a logic circuit, A driving unit, a first comparator, and a second comparator. In the constant current LED drive circuit provided by the present invention, when the state detection unit detects that the discharge time is less than the first minimum discharge time, the OVP protection will not be triggered immediately in this working cycle, but will be in the next two working cycles ( There is a preset time interval between the three working cycles), according to the new judgment standard (whether the discharge time is less than half of the first minimum discharge time), the discharge time is further judged, only when the OVP protection is continuously triggered, The corresponding shutdown protection will be carried out, which can greatly improve the anti-interference characteristics of the constant current LED drive circuit to interference signals.