The invention discloses a low-power consumption three-level operational amplifier for driving a large-load capacitor. The amplifier is composed of fifteen MOS transistors, two capacitors and a resistor Ra, wherein the fifteen MOS transistors comprise the first PMOS transistor M10, the second PMOS transistor M11, the third PMOS transistor M13, the fourth PMOS transistor M17, the fifth PMOS transistor M18, the sixth PMOS transistor M21, the seventh PMOS transistor M24, the eighth PMOS transistor M31, the first NMOS transistor M13, the second NMOS transistor M14, the third NMOS transistor M15, the fourth NMOS transistor M16, the fifth NMOS transistor M22, the sixth NMOS transistor M23 and the seventh NMOS transistor M30; the two capacitors comprise the first compensation capacitor Cm and the second compensation capacitor Ca. Compared with the prior art, the three-level operational amplifier can drive the large-load capacitor (hundreds of pF) under the low-voltage low-power consumption (microW) condition, and has a large gain bandwidth product and a better swing rate.