The invention is suitable for the technical field of
offset calibration, and provides a programmable
gain amplification circuit and an
offset calibration method thereof. The programmable
gain amplification circuit comprises an
operational amplifier, a first
resistor, a second
resistor, a first
capacitor, a second
capacitor, a first adjustable
resistor, a second adjustable resistor, a first input end, a second input end and a controller, one end of the first adjustable resistor is connected with the non-inverting input end of the
operational amplifier, the other end is connected with common
voltage, one end of the second adjustable resistor is connected with the inverting input end of the
operational amplifier, and the other end is connected with the common
voltage; the controller adjusts the resistance value of the first adjustable resistor and / or the resistance value of the second adjustable resistor, so that the output
voltage difference of the operational
amplifier is smaller than a preset voltage difference threshold value. According to the embodiment of the invention, the influence caused by the voltage offset of the pre-stage circuit can be effectively eliminated, and meanwhile, only two adjustable resistors are added, so that excessive
chip area is not occupied, and excessive
power consumption is not consumed.