The present invention relates to Erbium Ytterbium codoped multi-component oxide glass monomode fiber core glass and a method for preparing monomode fiber. The core glass comprises SiO2, Al2O3, Li2O, Yb2O3, Er2O3, B2O3, etc. A round bar is made from Erbium-doped glass blank, a core glass is formed by drawing it into a thin round bar; another round bar is made from non-Erbium-doped glass blank, a cladding glass is formed by laser punching it; the thin round bar is placed in the hole of the cladding glass to form an Erbium-doped optical fiber performrod; then a monomode fiber is obtained by drawing the performrod in a wire drawing furnace. The invention solves the problems in the prior art of uneven gain spectrum, narrow gain bandwidth, complicated preparing technology and so on. The Erbium Ytterbium codoped multi-component oxide optical glass fiber can provide transmission bandwidth of 60nm and more even gain spectrum, higher glass transition temperature, better chemical and heat stability, can satisfy the increased requirements of the current optical transmission network.