13 results about "Genetic samples" patented technology

The invention discloses a sample data expansion method and device for whole genome selection, equipment and a medium, and the sample data expansion method for whole genome selection comprises the steps: obtaining real genotype data of a target crop in a historical crop breeding process and phenotype data corresponding to the real genotype data, generating an initial sample set according to the real genotype data and the phenotype data; based on linkage feature information of the real genotype data, performing segment segmentation on initial gene sample data in the initial sample set, and performing segment replacement on segmented gene segments based on auxiliary gene sample data to generate a mixed gene sample; and training a pre-constructed crop prediction model based on the mixed gene sample and the initial sample set. According to the technical scheme, the prediction efficiency of crop character prediction and the reliability of the prediction result are improved.

The invention discloses a gene detection sample oscillation mixing device capable of accurately controlling the speed, and relates to the technical field of gene sample detection, the gene detection sample oscillation mixing device comprises a device host and a driving member, and is characterized in that the driving member is vertically embedded in the device host, and the top power output end of the driving member is horizontally connected with a rotating frame member. According to the gene detection sample oscillation mixing device capable of accurately controlling the speed, the oscillation frequency and amplitude can be accurately controlled according to preset parameters through a high-precision speed sensor and an intelligent regulation and control system which are arranged in the device host. And the driving component adopts an advanced motor driving technology, so that the stability and high efficiency of power output are ensured. And the rotating frame component is designed into an adjustable structure and can be flexibly adjusted according to the sizes of different sample containers, so that the uniformity of oscillation mixing is ensured. And the clamping component is made of a soft and elastic material, so that the sample container can be firmly clamped, and the damage to the sample in the oscillation process can be avoided.

The application provides a multiplex real-time fluorescent PCR reaction system based on probe differentiation design, corresponding fluorescent probes are designed based on target genes, the fluorescent probes are labeled with 1-3 fluorescent groups and 1-3 quenching groups, and the number and / or labeling position of the fluorescent groups and / or quenching groups carried by the fluorescent probes of different target genes are different. The reaction system can further carry multi-dimensional data analysis and a neural network model based on experience learning, unknown sample target gene sample types can be quickly and accurately judged, and accurate differentiation of multiple target genes in a single fluorescent channel can be realized.

A learning propensity information determination system based on genetic test information, according to one embodiment, comprises: a basic information generation unit for generating basic information by receiving information about a testee; a genetic test information generation unit for generating genetic information by analyzing a genetic sample of the testee; and a learning propensity information determination unit for generating cognitive category learning propensity information on the basis of the genetic information, generating non-cognitive category learning propensity information on the basis of the genetic information and the basic information, and generating learning propensity information by integrating the cognitive category learning propensity information and the non-cognitive category learning propensity information.

The application discloses a gene sample low-temperature storage transfer box, and relates to the technical field of gene sample storage and transfer devices.The gene sample low-temperature storage transfer box comprises a placing device, a taking-out device and a refrigeration device, the taking-out device is installed in the interior of the placing device, the taking-out device is used for assisting the smooth taking-out of the gene sample in the placing device, and the refrigeration device is used for adjusting the storage environment of the gene sample.The application has the following advantages: the position of the positioning arc plate can be adjusted according to the size and model of the vessel to be stored, the surface of the positioning arc plate is tightly combined with the outer surface of the vessel through the extrusion of the spring, the clamping and fixing of the vessel are completed, the position of the ejection plate is lifted by the adjusting frame when the vessel needs to be taken out and detected, and the vessel is ejected, so that the vessel can be conveniently taken out.

The invention discloses an endogenous circadian rhythm disorder quantification method and a related gene cluster detection method, and the method comprises the steps: collecting data, carrying out the normalization processing of the data, calculating the average expression of a gene sample, carrying out the statistics of the occurrence frequency of a circadian rhythm related gene, and distributing a weighted sampling probability. And performing centralization processing on the normalized matrix, calculating a random background score, calculating an observation score, and further calculating a rhythm disorder quantitative index score. According to the related gene cluster detection method, a rhythm disorder quantitative index scoring sample is taken as an input object, and a key gene cluster and a signal network occurring in the conversion process of a system from a steady state to a pathological state are analyzed and identified through a network. Rhythm disorder quantitative index scoring and related gene cluster detection methods cooperate with each other, so that quantitative and mechanical analysis of the circadian rhythm disorder state of the colorectal cancer patient can be realized. Scientific basis and clinical application potential are provided for molecular typing, risk assessment and potential target screening of colorectal cancer.

Genetic samples are obtained from separate people, and at least a portion of each are purposefully combined before testing to form a pooled genetic sample. The pooled genetic sample is tested for the presence of a signature for a given known ailment. DNA identification uses discovered InDels in a region of InDel variation in a genetic sample. A pair-wise comparison is performed to reference InDels, and a distance is measured between the first InDel and the reference Indel. Reference kmers are identified in a reference genome, and in a test sample. The plurality of sample kmers are filtered to those which have a 1 edit distance from a corresponding one of the plurality of reference kmers. Reads that have kmers that do not have a 1 edit distance from the corresponding one of the plurality of reference kmers are identified, and multiple single-mutations are eliminated from candidate InDel reads.

The invention relates to a device (1, 101) for detecting a genetic sample, comprising a housing (10, 110), a control unit (20, 120), a temperature control unit (30, 130) with a heating element, an illumination unit (40, 140) and a detection means, the control unit, the temperature control unit, the illumination unit and the detection means being arranged within the housing (10, 110), and a sample holding element being arranged within the housing (10, 110). The device (1, 101) further comprises a vortex centrifugation unit (50, 150) having a drive unit and a rotatable sample holding tray (55, 155) connected to the drive unit and provided with the sample holding element, wherein an oscillation element (57, 157) is provided in the center of the sample holding tray (55, 155). The housing (10, 110) consists of a first housing part (11, 111) and a second housing part (12, 112), which are separated by a partition wall (15, 115).

The invention discloses a heterogeneous multi-omics cancer prognosis prediction method based on a meta path. The method comprises the following steps: designing a gene expression level discrimination strategy to measure the gene expression level of a sample, and constructing a single omics gene-sample heterogeneous network; a sample similar network is constructed from multiple angles, firstly, a meta-path semantic division method is designed to construct a sample similar network based on meta-paths, nonlinear and high-order relationships among samples are captured, and secondly, a sample similar network based on Pearson's correlation coefficients is constructed; a similar network fusion method is introduced for fusion to obtain a double-sample similar network, and more accurate sample similarity is captured; a graph enhancement method based on class domain division is provided, and a more accurate sample similar network is obtained through sample adjacency matrix optimization based on class domain division; and finally, designing a multi-omics GCN to capture inter-omics information, and classifying samples by using an MLP. Multiple omics data such as miRNA, DNA methylation and mRNA can be integrated, and a good result can be obtained in downstream tasks such as cancer subtype typing.

The application discloses a gene selection method based on biological character expression of multi-target feature selection, which comprises the following steps: step 1, inputting biological gene samples; step 2, grouping features of the input gene samples and generating a sub-population for each group; step 3, independently evolving each sub-population; step 4, gradually merging all the sub-populations; and step 5, finally merging all the sub-populations into one population, searching on the original genes, finally obtaining the best partial genes on the original gene set in expression effect, and taking the partial genes as the finally selected genes. The application can screen a small number of important genes from a large number of gene features, thereby effectively improving the accuracy of gene selection of high-dimensional biological character expression, and is also beneficial to shortening a research period and reducing research cost.

Embodiments of the present application disclose a kind of based on gene and cell relationship's graph network construction method and device, the method includes: obtaining gene and cell in multiple samples, respectively carry out feature screening to gene and cell in each sample, obtain the gene and cell for indicating the characteristics of each sample;According to the gene and cell for indicating the characteristics of each sample, gene sample graph network and cell sample graph network are respectively constructed, and the importance of each node feature in the two sample graph networks is calculated respectively;According to the gene and cell that there is interaction relationship, and the importance of each node feature in the two sample graph networks, construct initial factor graph network;According to the adjacency matrix of factor graph network, whether there is other gene and cell that exists interaction relationship in factor graph network is predicted, and factor graph network is updated based on the gene and cell predicted.The present application solves the problem that gene and cell interaction relationship cannot be qualitatively and quantitatively analyzed in related art.

The present invention relates to a device (1, 101) for testing genetic samples, said device comprising a housing (10, 110), a control unit (20, 120), a temperature control unit (30, 130) with a heating element, an illumination unit (40, 140) and a detection means, which are arranged inside the housing (10, 110), and a sample holding elements arranged in the housing (10, 110). The device (1, 101) further comprises a vortex-centrifugation unit (50, 150) having a drive unit and a rotatable sample holding tray (55, 155) connected to the drive unit and provided with the sample holding elements, wherein a shaking element (57, 157) is provided on the centre of the sample holding tray (55, 155). The housing (10, 110) consists of a first housing part (11, 111) and a second housing part (12, 112) separated by a partition wall (15, 115).