81 results about "Genetic samples" patented technology

Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, untrained and unskilled users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter—steps which are largely effected during the shipping stage of the transfer process.

Disclosed are methods and kits for conducting anonymous genetic testing. The methods and kits include provide a patient with an Alias ID and Password. The Alias ID is used to track a genetic sample from the patient. Both the Alias ID and Password are then used by the patient to obtain the results of the genetic test. The methods and kits allow a patient to have a genetic test performed while remaining anonymous.

The present invention relates to the identification of a single nucleotide polymorphism (SNP) within the bovine CAST locus encoding the calpastatin protein, wherein the allelic variation of the SNP is a G/C transversion associated with post-mortem muscle tenderness. The invention further relates to oligonucleotides useful in identifying the genotype of bovines as it relates to the CAST locus polymorphic site. The invention also encompasses computer-assisted methods and systems for improving the production efficiency for livestock having marketably tender meat using multiple data, and in particular the genotype of the animals as it relates to the CAST SNP. These methods of the invention encompass obtaining a genetic sample from each animal in a herd of livestock, determining the genotype of each animal with respect to specific quality traits as defined by a panel of at least two single polynucleotide polymorphisms (SNPs), one SNP corresponding to a site between exons 5 and 6 of the bovine CAST locus, grouping animals with like genotypes, and optionally, further sub-grouping animals based on like phenotypes.

The invention discloses an automatic storage and taking device for biological samples, and belongs to freezing storage devices of biological samples. The automatic storage and taking device comprises a freezing storage tank, a taking chamber positioned on the freezing storage tank, a sample storage rack positioned inside the freezing storage tank, a storage and taking bin which communicates with the taking chamber, and a sample recognition system positioned inside the storage and taking bin, wherein the sample storage rack comprises a chassis rotatably arranged inside the freezing storage tank and a plurality of lifting racks on the chassis; a plurality of layers of storage boxes are placed on the lifting racks; the lifting racks are equipped with lifting devices; a bracket which slides towards the taking chamber and supports the storage boxes is arranged inside the storage and taking bin; a clamping device positioned above the bracket is arranged inside the storage and taking bin; the clamping device is equipped with a driving mechanism used for driving the clamping device to move; a sample taking hole is formed in the bottom of the storage and taking bin; a sealing cover is equipped with an opening-closing device; and a sample transfer device is arranged below the sealing cover. According to the automatic storage and taking device, the problems that in the prior art, the storage and taking are inconvenient, the activity of other biological samples is affected, and the taking and placing accuracy and efficiency of the storage and taking bin for genetic samples are relatively low are solved.

Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.

Bi-directional cattle traceability process comprising five basic stages: a first document traceability and sanitary certification chain stage, wherein the animals are identified by birth certificates, animal identification attached to the animal's ear and registered in a data centre. A second stage for transfer of animals to another establishment, wherein genetic material is extracted from the offspring not yet weaned, filed and registered and registered in the data centre. A third stage for slaughtering of animals, wherein the slaughtered animal's ear is cut off where the animal identification is attached and the animal identification is read on line, the half carcases have sealed strips applied to them, DNA samples are extracted from the animal, then deposited in the official genetic bank and on each cut a locket sampler is attached encrypting a genetic and biochemical sample. A fourth stage for transfer or exporting of cuts, wherein the barcode that originated the cut is identified and applied to each portion of this cut or piece into which it is divided and then the locket sampler is removed from each sliced or minced cut, to deposit it in the cold storage chamber. A fifth and last stage of traceability auditing, wherein three samples of the identified portion of a cut to de audited are taken and adulteration of the cut or non-adulteration is determined by comparing the genetic sample taken in the third stage with the encrypted genetic sample in the locket sampler that held the original cutting extracted in the fourth stage.

Alternative traceability processes addressed to fishing and canning and a set of elements used in the different stages of the three processes are also disclosed.

The invention discloses automatic storing and taking equipment for a biological sample and relates to the technical field of storing and taking equipment for biological gene samples. The automatic storing and taking equipment comprises a low-temperature storing tank, a conveying bin arranged above the low-temperature storing tank and an extracting opening for enabling the conveying bin to be communicated with the low-temperature storing tank; a sample storing rack, a sample box temporary placing area and a second manipulator for storing and taking a sample box in the low-temperature storing tank, wherein multiple lines of unit racks are arranged on the sample storing rack; a first manipulator is arranged in the conveying bin; in addition, a sealing cover matched with the extracting openingand an uncovering mechanism for opening and closing the sealing cover are also arranged in the conveying bin. According to the automatic storing and taking equipment disclosed by the invention, the condition that the quality of the sample is affected because the sample is taken out of the low-temperature storing tank, and enters a noncryogenic environment for transferring and extraction is avoided; meanwhile, the consumption of low-temperature nitrogen is reduced.

The invention belongs to field of bioengineering, and particularly relates to an SNP (single nucleotide polymorphism) site detection method based on an SOLID (supported oligo ligation detection) sequencing technique. The method comprises the following steps: (1) obtaining a color sequence of a gene sample to be detected in an SOLID sequencing manner; (2) preparing the color sequence of a reference order; (3) preparing an index table of a color coding reference order to rapidly position a sample order; (4) comparing an SOLID sequencing sample order with the color coding reference order so as to find out the optimal matching position of the sample order in the reference order, comparing the sample order with the reference order so as to obtain color encoding matching information; (5) analyzing base matching information of the SOLID sample order and the color encoding reference order according to the color encoding matching information, and determining uncertain change points; (6) counting the obtained uncertain change points, and removing noise and the uncertain change points caused by a sequencing error, so as to obtain a sample SNP site. By adopting the SNP detection method disclosed by the invention, the characteristic of high positioning accuracy of an SOLID data in a comparison process is kept; the accuracy of the SNP analysis method is also improved.

The invention provides a tumor gene identification method based on a gene expression profile, which is characterized in that gene expression matrixes of gene samples are studied by adopting a locality preserving projection method and a kernel-function nearest neighbor classification method under the assistance of a computer, the gene expression matrixes of the gene samples are projected into a low-dimensional embedding space so as to reveal a low-dimensional manifold structure hidden in high-dimensional gene expression profile data, and low-dimensional characteristic matrixes are classified by adopting the kernel-function nearest neighbor classification method so that the unrevealed characteristics in the low-dimensional characteristic matrixes are revealed, further the tumor genes in the gene samples are distinguished, and the tumor genes are identified. The method provided by the invention has high rate of identification and good reference value to the clinical diagnosis of the tumor genes and can be applied to establishing a tumor gene identification system.

The invention relates to an assay method allowing the quantification of the copy number of a repeated nucleic acid sequence in a genetic sample. Typically such sample comprises the genome of a microbial, plan, animal or human subject. Furthermore, the invention provides a particular example wherein the assay is used to determine the susceptibility to disease of a subject. Such information can be used in selecting the optimal treatment for a particular diseased subject.

The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates tomanufacturing and using arrays and analytical approaches based on single molecule detection techniques.

The invention discloses a gene sample transfer bin and relates to the technical field of biological gene sample storing and taking equipment. The gene sample transfer bin comprises a bin body, a feedmechanism, a mechanical arm, a unit frame extraction mechanism and a fixture supporting mechanism, wherein the feed mechanism, the mechanical arm, the unit frame extraction mechanism and the fixture supporting mechanism are mounted in the bin body. The bin body comprises a table board and a shell cover. The shell cover is provided with a feed port corresponding to the feed mechanism. The shell cover is provided with a door opening and closing mechanism used for opening and closing the feed port. The table board is provided with a sampling port and a sealing cover matched with the sampling port. The sealing cover is equipped with a cover opening mechanism. The gene sample transfer bin can effectively protect low-temperature nitrogen in the bin body against leakage and reduce loss of liquidnitrogen and meanwhile can guarantee good activity of biological tissues in test tubes in the process of transferring the test tubes.

The invention belongs to the medical field and relates to a biological (gene) information detection and auxiliary diagnosis service device, in particular, a gene detection unmanned sale experience system. The implementation process of the system includes the following steps that: 1, consumer gene detection project products are introduced and sold, samples are acquired and collected, and the gene samples are stored in an acquisition device; 2, professionals transport the genetic samples from the acquisition device to a detection center, and the detection center detects the gene samples; and 3,gene sample detection results are sent to consumers. The gene detection experience device comprises a monitoring module used for detecting whether a first terminal device acquires data information, astorage module used for storing the data information, and an update module used for updating the data information. With the system and device provided by the embodiments of the present invention adopted, the consumers can be facilitated to perform gene detection, and the information security of the consumers can be ensured.

Methods of selecting a chemotherapy regimen for treatment of cancer in a patient are disclosed. A patient genetic sample from a bilary cancer such as cholangiocarcinoma is analyzed for a mutation in ERRFI1 and a chemotherapeutic agent is selected as a result of the analysis. If a mutation in ERRFI1 is present, treatment with an inhibitor of Epidermal Growth Factor Receptor (EGFR) is shown to have inhibitory effects on tumor growth. In this manner, the chemotherapy regimen is targeted to a given mutation in a patient's cancer.