The invention provides an automatic uncertainty analysis platform and method based on large-scale CFD parallel computing software. The automatic uncertainty analysis platform comprises a user interaction module, a database, a server, a CFD test module, an NIPC, a post-processing module and a monitoring module. The database is connected with the user interaction module and the server, the server module is connected with and controls the CFD test module, the monitoring module and the NIPC and post-processing module, the CFD test module comprises sample generation, batch processing and automatic calculation, and finally a plurality of calculation results are output to the NIPC and post-processing module. And after uncertainty analysis and result post-processing, an analysis result and original data are returned to a database and finally returned to the user interaction module. According to the method, automatic uncertainty analysis of large-scale CFD software is completed through the processes of network access, automatic example and sample loading, cluster calculation submission, real-time progress monitoring, NIPC uncertainty analysis, automatic post-processing and the like, and experimental comparison diagrams, analysis reports, summary reports and the like are provided.