7 results about "Solution phase synthesis" patented technology

The application discloses an aluminum-tantalum modified high-nickel ternary positive electrode material and a preparation method and application thereof. The application starts from solution phase synthesis control, first constructs a nano coating containing aluminum-tantalum metal on the surface of the high-nickel ternary positive electrode material, and then further carries out high-temperature heat treatment to promote chemical reaction between the positive electrode material and the surface coating, so that a surface structure with good stability and high charge transport capacity is obtained, thereby significantly improving the stability of the positive electrode material and obtaining the positive electrode material with high specific capacity and good cycle stability. Meanwhile, the method provided by the application can fully meet the needs of scale production on the premise of ensuring that no additional damage is caused to the high-nickel ternary positive electrode material, has the advantages of low cost, high reliability and the like, and has a wide application prospect.

The invention belongs to the technical field of polypeptide synthesis, and provides a liquid-phase synthesis method of polypeptide. The liquid-phase synthesis method of the polypeptide comprises the following steps: removing an R1 protecting group and an R2 protecting group from a compound A: R1-Ala-Glu (R2)-Pro-Val-Pro-Leu-OR2 by adopting a fractional step method or a one-step method, and purifying to obtain the polypeptide, wherein R1 comprises one of Boc and Fmoc, and R2 comprises one of Et, Obzl and tBu. The full-liquid-phase and fragment condensation method provided by the invention is simple and convenient to operate, easy in intermediate purification, high in intermediate purity, stable and reliable in process, low in equipment dependence, low in raw material cost and beneficial to large-scale production.

The invention discloses a P-modified cuprous oxide catalyst and a preparation method thereof, the P-modified cuprous oxide catalyst is synthesized through copper acetate, hydrazine hydrate and a phosphoric acid aqueous solution by a solution phase synthesis method, the catalyst can slow down reconstruction and reduction of cuprous oxide and improve electrocatalytic activity, and the preparation method is relatively simple.

The present application provides novel long-acting Amylin receptor agonists and uses thereof. The Amylin receptor agonists are prepared by solid phase synthesis and / or solution phase synthesis, cleavage of the peptide resin, formation of a disulfide bond between the thiol groups of Cys2 and Cys7, RCM ring closure of the side chains of AA2 and AA7 double bond, hydrogenation, and optional isolation and purification. The compounds disclosed herein can be used in combination with one or more additional therapeutic agents for the treatment of diabetes and its complications, obesity and its complications, dyslipidemia, hypertension, OSA, and / or NASH, either simultaneously, separately or sequentially.

The invention provides a novel long-acting Amylin receptor stimulant and application thereof. The Amylin receptor stimulant is prepared by solid-phase synthesis and / or liquid-phase synthesis, cracking of peptide resin, formation of disulfide bonds from sulfydryl groups of second Cys and seventh Cys, cyclization of RCM of side chain double bonds of second AA and seventh AA, hydrogenation and optional separation and purification. The compounds disclosed herein may be used simultaneously, separately, or sequentially in combination with one or more additional therapeutic agents for the treatment of diabetes and complications, obesity and complications, dyslipidemia, hypertension, OSA, and / or NASH.

Disclosed is a lipophilic agent comprising a triazine core having lipophilic groups for organic synthesis. The lipophilic agent soluble in one system of solvent(s) wherein the lipophilic agent is participated in a chemical reaction but insoluble by adding a miscible poor solvent to change solution composition after the reaction completes. The lipophilic agent facilitates process improvement wherein practical operation only involves mixing with reactants in solution followed by precipitating with change of solution composition followed by filtering to obtain the precipitated solid, simplifying the purification by isolating the desired solid. The operation is reproducible along the progress in a multi-step synthesis, allowing pure intermediates and pure product as a solid to be rapidly obtained with ease and certainty. This invention can thus accelerate research and development of pharmaceutical biomolecules, representing a tremendous step forward for boosting productivity and greening chemical industry.

Disclosed is a lipophilic agent comprising a triazine core having lipophilic groups for organic synthesis. The lipophilic agent soluble in one system of solvent(s) wherein the lipophilic agent is participated in a chemical reaction but insoluble by adding a miscible poor solvent to change solution composition after the reaction completes. The lipophilic agent facilitates process improvement wherein practical operation only involves mixing with reactants in solution followed by precipitating with change of solution composition followed by filtering to obtain the precipitated solid, simplifying the purification by isolating the desired solid. The operation is reproducible along the progress in a multi-step synthesis, allowing pure intermediates and pure product as a solid to be rapidly obtained with ease and certainty. This invention can thus accelerate research and development of pharmaceutical biomolecules, representing a tremendous step forward for boosting productivity and greening chemical industry.