34 results about "Solution phase synthesis" patented technology

The invention discloses a preparation method of a metallic oxide/N-doped carbon nano tube composite material. The preparation method comprises the following steps of: (1) ultrasonically dispersing an N-doped carbon nano tube in a mixed solution of water and alcohol to obtain a solution A; (2) under the condition of stirring, dripping a solution B into the solution A, and stirring to obtain a mixed solution, wherein the solution B is water and/or alcoholic solution containing metal ions; and (3) carrying out solid-liquid separation on the mixed solution, and washing, drying and roasting to obtain the metallic oxide/N-doped carbon nano tube composite material. The invention also provides the composite material obtained through the method and an application thereof. According to the preparation method disclosed by the invention, as a method of solution phase synthesis under the condition of room temperature is adopted, hydrothermal reaction and solvothermal reaction with high temperature and high pressure are avoided, and the composite material with tighter combination of the metallic oxnide and the /N-doped carbon nano tube can be obtained. By adopting the preparation method, the preparation cost is low, the operation is simple, the preparation condition is mild, and the reaction period is also short.

A multi-element metal chalcogenide and a method for preparing the same are provided. According to the present invention, the multi-element metal chalcogenide includes multiple metal elements. According to the present invention, a multi-element metal chalcogenide powder is prepared, and all of the multiple metal elements of the multi-element metal chalcogenide are derived from simple substance powders of the metal elements, and/or one or more alloy powders mixed in accordance with a mole ratio. Then, a solution phase synthesis of the powder of the multi-element metal chalcogenide is conducted under the normal pressure to prepare the multi-element metal chalcogenide. The multi-element metal chalcogenide can be coated to obtain a film or used to make a target and then bombard the target for sputtering a film. In such a way, a selenization process which is conventional in fabricating the semiconductor solar cell is eliminated, thus improving the production yield and efficiency.

The invention provides methods for solution-phase synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.

Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.

Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.

The invention discloses a preparation method capable of achieving large-scale preparation of super-paramagnetic Fe3O4@Au-core@shell structured nanorods with controllable size and dispersion, and belongs to the field of intersection of multiple subjects such as macromolecular living polymerization methods, functional polymer molecule design and inorganic crystal growth. The method comprises the following steps that (1), cellulose used for modifying hydroxide radical serves as a macromolecular initiator, and by means of a continuous polymerization ATRP technology and a linked chemical reaction,a series of brush-shaped triblock polymers cellulose-g-[P4VP-b-PAA-b-PS] and cellulose-g-[P4VP-b-PAA-b-PEG] are prepared separately, wherein the triblock polymers each comprise two template structureunits; (2), a solution-phase synthesis method serves as a basis, a certain quantity of the above-mentioned prepared brush-shaped triblock polymers serves as a monomolecular template, first section P4VP serves as a template phase, FeCl2.4H2O, FeCl3.6H2O and NH3.H2O serve as a precursor compound system, and then super-paramagnetic Fe3O4 nanorods are firstly prepared to serve as cores; and (3), similarly, a Fe3O4 nanorod system with the surface coated with a second template phase PAA serves as the monomolecular template, chloroauric acid serves as a precursor compound, tert-butylamine boron serves as a reducing agent, and then the gold nanorod shell structure is prepared.

The invention discloses a preparation method of gold nanorods with large-scale preparation and controllable sizes and dispersibility, and belongs to the multidisciplinary field of polymeric activity polymerization methods, functional polymer molecular design, inorganic crystal growth, etc. The method comprises the steps: (1) taking ionic liquid AMIMCl as solvents, and anhydrous dimethylformamide and N-Methyl pyrrolidone (NMP) as diluents and acid absorbents separately, applying 2-bromoisobutyryl bromide to hydroxyls on a cellulose chain, and converting the hydroxyls into macroinitiators whichcan be used for atom transfer radical polymerization (ATRP); (2) preparing a series of brushy two-block polymers: cellulose-g-[PAA-b-PS] and cellulose-g-[PAA-b-PEG] with a continuous ATRP technology,a technology of combination of ATRP and Click Chemistry and other technologies by taking cellulose-Br as the macroinitiators; and (3) preparing the gold nanorods with oil dispersibility and water dispersibility based on a solution phase synthesis method by taking a certain amount of the brushy two-block polymers as monomolecular templates, chloroauric acid (HAuCl4.3H2O) as precursor compounds andtert-butylamine boron (TBAB) as reducing agents.

The invention discloses a preparation method and application of water-soluble titanium dioxide nanoparticles. According to the preparation method, beta-cyclodextrin is used as an initial reaction material, a macroinitiator is synthesized by means of modification, a multi-arm star-shaped block copolymer is prepared by using an atom transfer radical polymerization (ATRP) technology and a technologywhich combines ATRP with 'click' chemistry, and the water-soluble titanium dioxide nanoparticles with uniform sizes and good dispersibility are prepared by taking the multi-arm star-shaped block copolymer as a monomolecular micelle template on the basis of a solution phase synthesis method. The titanium dioxide nanoparticles prepared by the preparation method are stable in quality, uniform in particle sizes, and can be stabilized at a nanoscale; the properties of the titanium dioxide nanoparticles can be effectively enabled to be exerted. The surfaces of the titanium dioxide nanoparticles aremodified, so that the titanium dioxide nanoparticles can be enabled to be evenly dispersed in water, and an aggregation effect is further avoided.

This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

The present process provides a method for synthesizing difficult to make oxide-free nanometals and such as Zn, Sn and Ti and alloys of the period 4 and 5 transition metal elements in a free and reduced state using a solution phase synthesis process. Also provided is a method for stabilizing their associated colloidal metal and alloy dispersions under kinetic control at modest temperatures (<80 degrees Celsius). A solution of an organic reducing agent containing at least two proximal nitrogen atoms is reacted with a separate solution containing one or more metal-organic salts dissolved in the same or different low molecular weight solvent as the reducing agent. The reaction products are stabilized with Lewis bases and Lewis acids and optionally can be concentrated by removing a portion of the volatile low molecular weight solvent by either the use of a partial vacuum or by chemical extraction into another phase.

The invention discloses a preparation method of oil soluble silver nanoparticles. Beta-cyclodextrin is adopted as initial reaction raw materials; a macroinitiator is synthesized by finishing; an ATRPtechnology and an ATRP and linkage chemical (Click Chemistry) combination technology are adopted to prepare a multi-arm star segmented copolymer; a solution phase synthesis method is used as the base;and the multi-arm star segmented copolymer is used as a single-molecule micelle template to prepare the oil soluble silver nanoparticles with uniform sizes and excellent dispersibility. The surfacesof Ag nanoparticles are modified, so that the Ag nanoparticles can be uniformly dispersed in oil solvent to prevent the agglomeration effect. The prepared Ag nanoparticles are stable in quality and uniform in size, can be stabilized in nanoscale, and can effectively guarantee the performance exertion.

The invention discloses a preparation method capable of preparing a superparamagnetic Fe3O4 nanorod with controllable size and dispersity in a large scale, belonging to the multidisciplinary fields like polymer active polymerization process, functional polymer molecular design and inorganic crystal growth. The method comprises the following steps: (1) with an ionic liquid AMIMCl as a solvent and anhydrous dimethylformamide and N-methylpyrrolidone as a diluent and an acid absorbent, modifying hydroxyl on the chain of cellulose by using 2-bromoisobutyryl bromide so that a macromolecular initiator capable of being used for atom transfer radical polymerization is obtained; (2) by utilizing a continuous polymerization ATRP technology and a click chemistry reaction, respectively preparing a series of brush-shaped di-block polymers, i.e., cellulose-g-[PAA-b-PS] and cellulose-g-[PAA-b-PEG]; and (3) on the basis of a solution phase synthesis method, and with a certain amount of the above-mentioned prepared brush-shaped di-block polymers as a monomolecular template and FeCl2.4H2O, FeCl3.6H2O and NH3.H2O as a precursor compound system, preparing the superparamagnetic Fe3O4 nanorod with oil dispersity and water dispersity.

The present process provides a method for synthesizing oxide-free copper nanometal dispersion in a free and reduced state using a solution phase synthesis process. A solution of an organic reducing agent containing at least two proximal nitrogen atoms is reacted with a separate solution containing a copper salt reformulated into a charge transfer complex. The reaction products are stabilized with Lewis bases and Lewis acids and optionally can be concentrated by removing a portion of the volatile low molecular weight solvent by either the use of a partial vacuum or by chemical extraction into another phase.

The invention discloses a preparation method of oil soluble titanium dioxide nanometer particles. According to the method, beta-cyclodextrin is taken as a primary reaction material and is synthesizedinto a macroinitiator through modification; multi-arm star block copolymer is formed through a technology of combination of ATRP and click chemistry; the oil soluble titanium dioxide nanometer particles with uniform sizes and excellent dispersity, based on a solution phase synthesis method and taking the multi-arm star block copolymer as a unimolecular micelle template, are formed. The surfaces ofthe TiO2 nanometer particles are modified, the TiO2 nanometer particles can be uniformly dispersed in an oily solvent, and the occurrence of aggregation effect can be avoided. The formed nanometer particles are stable in quality, the particle sizes are uniform and can be stabilized in nanoscale, and that performance of the TiO2 nanometer particles is realized can be effectively guaranteed.

Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure

are prepared in accord with preferred embodiments.

The invention relates to an improved method for a 5+3+2 solution phase syntheses of Icatibant acetate (1) comprising coupling of suitably protected peptide fragments which on deprotection followed by treatment with acetic acid provide Icatibant acetate (1) having desired purity.

The present process provides a method for synthesizing difficult to make oxide-free nanometals and such as Zn, Sn and Ti and alloys of the period 4 and 5 transition metal elements in a free and reduced state using a solution phase synthesis process. Also provided is a method for stabilizing their associated colloidal metal and alloy dispersions under kinetic control at modest temperatures (<90 degrees Celsius). A solution of an organic reducing agent containing at least two proximal nitrogen atoms is reacted with a separate solution containing one or more metal-organic salts dissolved in the same or different low molecular weight solvent as the reducing agent. The reaction products are stabilized with Lewis bases and Lewis acids and optionally can be concentrated by removing a portion of the volatile low molecular weight solvent by either the use of a partial vacuum or by chemical extraction into another phase.

The invention discloses a simple and convenient resorcinol formaldehyde resin hollow composite material and a preparing method of derivative thereof. A surfactant modified hollow glass microspheres serves as a carrier, an in situ polymerization mode is used to enable the hollow glass microspheres to be coated by the resorcinol formaldehyde resin, the resorcinol formaldehyde resin hollow composite material is obtained and performs carbonizing treatment in the high temperature, and the resorcinol formaldehyde resin charring derivative is obtained. A mild solution phase synthesis method is utilized by the simple and convenient resorcinol formaldehyde resin hollow composite material, expensive reaction reagent does not need to be used, the carrier adopted is a high temperature-resistant material with a closed hollow structure, and the resorcinol formaldehyde resin hollow composite material can be obtained through one step without the removal of a template. The resorcinol formaldehyde resin hollow composite material has the characteristics of having a cavity structure and being low in density, good in dispersibility, simple in preparing method, low in weight and ablation resistance. The charring derivative with the cavity structure can be obtained through the carbonizing treatment and has the characteristics of being low in weight, easy to separate and ablation resistance.