40results about How to "Avoid chemical degradation" patented technology

Controlled release oral dosage forms are provided for the continuous, sustained administration of a pharmacologically active agent to the upper gastrointestinal tract of a patient in whom the fed mode as been induced. The majority of the agent is delivered, on an extended release basis, to the stomach, duodenum and upper regions of the small intestine, with drug delivery in the lower gastrointestinal tract and colon substantially restricted. The dosage form comprises a matrix of a biocompatible, hydrophilic, erodible polymer with an active agent incorporated therein, wherein the polymer is one that both swells in the presence of water and gradually erodes over a time period of hours, with swelling and erosion commencing upon contact with gastric fluid, and drug release rate primarily controlled by erosion rate.

The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.

A method for preparation of iodizing agent for the use in the formulation of iodised salt that offers excellent stability of iodine in iodised salt is developed and the unrefined salt iodised with this compound was tested for its stability in presence of moisture, temperature and metal salts at higher temperature. The hydrotalcite type layered compound was used to prepare such compound and part of carbonate was substituted with iodate anion. The iodising agent exhibited excellent stability of iodine in iodised salt.

This invention relates to aqueous solution compositions of vancomycin that are stable, ready for use and do not require reconstitution.

The invention discloses a PEM water electrolysis proton membrane and CCM integrated preparation process and equipment, the equipment adopts a combination of multiple nozzles and a slit type coating head, the multiple nozzles can independently spray different components of a catalyst layer multi-component composite slurry within an ultra-short time, the spraying rate and atomization degree of the different components are accurately controlled, and the production efficiency is improved. The problem of poor dispersibility of different catalysts and binders in the catalyst slurry in the same solution is solved; the preparation process comprises the following steps of: sequentially compounding the base membrane pretreatment layer, the catalyst layer 1, the functional layer 1, the composite reinforced membrane, the functional layer 2, the catalyst layer 2 and the like on the substrate to realize the integrated preparation of the PEM water electrolysis composite reinforced membrane and the CCM catalyst layer; and finally, the PEM membrane electrode has relatively low surface resistance, relatively high conductivity, mass transfer rate and chemical durability, so that the cost of PEM electrolyzed water is reduced, and the service life is prolonged.

The invention relates to an injection preparation containing camptothecin analogue, and the injection, the preparation and the application thereof. The injection preparation comprises a solid part and a liquid part which are separately and independently packaged, wherein the solid part adopts a freeze-dried powder; the freeze-dried powder comprises an active component and one or more pharmaceutically acceptable excipients; the active component adopts the camptothecin analogue or pharmaceutically acceptable salt; the liquid part at least comprises the following components: a solubilizer and water for injection; the camptothecin analogue has the structure as shown in the specification.

The method of directly using ordinary food to construct a nutrient nano-carrying system is characterized by: (1) mixing food raw materials with a lipid content of less than 12% and nutrients at a mass ratio of 4-200:1, and then performing nano-processing, so that the particle diameter The distribution peak is below 600nm; (2) In the solution system, the concentration of the solution is adjusted to 0.5%-55% based on the quality of nano-food, and then the pH is adjusted to 2.2-13, and the ionic strength is converted to a sodium ion concentration of 0.001mol/L to 5mol/L, adopt ultrasonic oscillation of 0-65W/cm2, the temperature is 0-85°C, after 1-48 hours of aggregation process; or, in the solid state, control the temperature at 0-230°C and the pressure at 0.05-4MPa, The relative humidity is 0-100%, after 2-80 hours of accumulation; (3) Vacuum packaging, storage at room temperature or low temperature. The present invention wraps nutrients in nano-food clusters to realize the delivery of nutrients, improves stability, can be stored in liquid or solid state, can reduce or even avoid the degradation of nutrients, and has loose post-processing conditions; Greater improvement.

The invention relates to a polyvinylidene fluoride-based terpolymer and a preparation method thereof. The polyvinylidene fluoride-based terpolymer comprises a polyvinylidene fluoride structural unit,an acrylamide structural unit and a perfluorovinyl ether lithium sulfonate structural unit, the preparation method comprises the following steps: respectively adding a vinylidene fluoride monomer, anacrylamide monomer, a perfluorovinyl ether lithium sulfonate monomer and an initiator into a reaction device, and carrying out one-step copolymerization by virtue of a polymerization reaction method.According to the invention, the advantage structure of polyvinylidene fluoride is retained, enough mechanical strength and thermal stability of the copolymer are ensured, the defects of the existing PVDF as a polymer lithium ion battery material are overcome by introducing a lithium ion high-efficiency transmission structural unit, a polar group and a large number of super-stable structural units,the transmission efficiency of lithium ions is optimized, the ionic conductivity of the lithium battery is improved, the polarization of the battery in the charging process is reduced, the charging and discharging performance of the battery is improved, and a new material and a new method are provided for further development and application of the lithium battery.

The invention relates to a hydrophilic lithium carbonate terpolymer and a preparation method thereof. The hydrophilic lithium carbonate terpolymer comprises a polyvinylidene fluoride structural unit composed of vinylidene fluoride monomers, a vinyl pyrrolidone structural unit composed of vinyl pyrrolidone monomers and a vinyl-alkyl lithium carbonate structural unit. The preparation method comprises the following steps: respectively adding the vinylidene fluoride monomers, the vinyl pyrrolidone monomers, the vinyl-alkyl lithium carbonate monomers and an initiator into a reaction device, and conducting copolymerizing by adopting a polymerization reaction method. According to the invention, the structural advantages of polyvinylidene fluoride are retained, the defects of polyvinylidene fluoride are overcome, and thermal stability is improved; the crystallinity, the ion conductivity and the ion migration rate of the copolymer can be effectively regulated and controlled by regulating and controlling the proportions of ion structure units, so the purpose of optimizing ion transmission is achieved; hydrophilic groups are introduced to improve hydrophilicity, so the adsorption capacity ofthe electrolyte and the migration rate of lithium ions are improved; and the physical and chemical properties of the copolymer can be effectively regulated.

The invention discloses a chelating agent and permeable reactive barrier combined electric contaminated soil remediation device and method.The device comprises a reaction bin and partition plates, the partition plates divide the reaction bin into an anode chamber, a soil sample chamber and a cathode chamber, an anode plate is arranged in the anode chamber, and a cathode plate is arranged in the cathode chamber; the device further comprises a permeable reactive barrier, an anolyte pH regulation and control unit and a catholyte circulating unit. An anode overflow hole is formed in the anode chamber, and a cathode overflow hole is formed in the cathode chamber; the anolyte pH regulation and control unit comprises a first peristaltic pump, an alkali liquor storage tank, an anolyte recovery tank, a pH controller and a pH sensor; and the catholyte circulating unit comprises a second peristaltic pump and a catholyte storage tank. According to the device, the chelating agent and the permeable reactive barrier can be effectively combined to electrically repair the heavy metal polluted soil body, the effect of the chelating agent can be fully played, meanwhile, heavy metal aggregation can be avoided, and the repair efficiency is higher.

The invention belongs to the field of alkaline electrolyte membranes, and the invention also relates to a composite alkaline electrolyte membrane based on the electrostatic interaction of the ionic liquid. The membrane is composed of an organic polymer skeleton and the ionic liquid. The ionic liquid is adsorbed on an organic polymer skeleton by virtue of electrostatic interaction; and the alkalineelectrolyte membrane has good chemical stability and high conductivity, and can be used in a high-temperature (more than 90 DEG C) environment.

A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.

The invention discloses a vinylidene fluoride terpolymer and a preparation method thereof, wherein the molecular structural formula of the vinylidene fluoride terpolymer is defined in the specification, and in the formula, the unit A is a vinylidene fluoride structural unit, the unit B is a vinyl alcohol structural unit, the unit C is a vinyl lithium carbonate structural unit, and n is greater than or equal to 1. The preparation method comprises the following steps: copolymerizing a vinylidene fluoride monomer, a vinyl ester monomer and a vinyl lithium carbonate monomer by a one-step method, and adding alkali for hydrolysis to obtain the vinylidene fluoride terpolymer. The preparation method disclosed by the invention is simple in process and low in cost, and provides a new technical thought for PVDF modification; and the prepared vinylidene fluoride terpolymer has high ion transmission efficiency, does not have the defect of poor compatibility of blended PVDF, and has great application prospects.

The invention discloses a lithium sulfonate terpolymer and a preparation method thereof. The lithium sulfonate terpolymer comprises a polyvinylidene fluoride structural unit, a vinyl benzyl structuralunit and a perfluorovinyl ether lithium sulfonate structural unit, the preparation method comprises the following steps: respectively adding a vinylidene fluoride monomer, a vinyl benzyl monomer, a perfluorovinyl ether lithium sulfonate monomer and an initiator into a reaction device, and carrying out one-step copolymerization by virtue of a polymerization reaction method. According to the invention, the advantage structure of polyvinylidene fluoride is retained, enough mechanical strength and thermal stability of the copolymer are ensured, the defects of the existing PVDF as a polymer lithium ion battery material are overcome by introducing a lithium ion high-efficiency transmission structural unit, a polar group and a large number of super-stable structural units, the transmission efficiency of lithium ions is optimized, and the battery performance is improved. The ionic conductivity of the lithium battery is improved, the polarization of the battery in the charging process is reduced, the charging and discharging performance of the battery is improved, and a new material and a new method are provided for further development and application of the lithium battery.

The invention discloses a PEM water electrolysis proton membrane and CCM integrated preparation method and device, the device adopts a combination of multiple nozzles and a slit type coating head, the multiple nozzles can independently spray different components of a catalyst layer multi-component composite slurry within an ultra-short time, the spraying rate and atomization degree of the different components are accurately controlled, and the production efficiency is improved. The problem of poor dispersibility of different catalysts and binders in the catalyst slurry in the same solution is solved; the preparation method comprises the following steps: sequentially compounding the base membrane pretreatment layer, the catalyst layer 1, the functional layer 1, the composite reinforced membrane, the functional layer 2, the catalyst layer 2 and the like on the substrate to realize the integrated preparation of the PEM water electrolysis composite reinforced membrane and the CCM catalyst layer; and finally, the PEM membrane electrode has relatively low surface resistance, relatively high conductivity, mass transfer rate and chemical durability, so that the cost of PEM electrolyzed water is reduced, and the service life is prolonged.