The invention discloses a fireproof and leakproof system for a high-temperature centrifugal pump, and belongs to the field of chemical equipment. The fireproof and leakproof system comprises a pump body, a non-driving-end bearing housing, a driving-end bearing housing and a shaft, the non-driving-end bearing housing and the driving-end bearing housing are of sealed structures and are fixed onto the pump body, a bearing is positioned in a sealed cavity of each bearing housing, the shaft penetrates through the bearings and the pump body and is fittingly fixed, a gas inlet and a condensate drain opening are disposed on each bearing housing, each gas inlet is connected with a gas pipeline, a gas inlet valve is disposed on each gas pipeline, the gas pipelines are connected with a gas delivery pipe, and a condensate drain valve is arranged on each condensate drain opening. The gas delivery pipe is connected with a gas supply device. Each bearing housing is provided with a pressure monitoring device. Opening and closing of each condensate drain valve are adjusted by a remote control device. The bearing housings at two ends of the pump are of the sealed structures after change, the fireproof and leakproof system is provided with vapor seals or gas seals, when seal leakage occurs, water vapor or nitrogen is filled into the pump via a control system, oil gas leakage is stopped, and fire accidents are prevented. Furthermore, combustion can be reduced by the aid of blowing and diluting effects of the water vapor or the nitrogen, fire is quickly extinguished, and accordingly loss is reduced.