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38results about How to "Guaranteed arrival" patented technology

Polypeptide, nucleic acid for coding polypeptide, polypeptide-modified T lymphocyte and application of T lymphocyte

The invention belongs to the technical field of biology, and discloses a polypeptide containing two chimeric antigen receptor structures, nucleic acid for coding the polypeptide, a modified T lymphocyte, and a preparation method and application of the T lymphocyte. The polypeptide provided by the invention contains the two chimeric antigen receptor (CAR) structures, wherein one chimeric antigen receptor structure specifically targets a tumor cell, and the other one specifically targets a normal B lymphocyte, so that a CAR-T cell is effectively amplified through recognizing the B lymphocyte ofa blood circulation system, and more CAR-T cells arrive at a solid tumor part so as to specifically kill the tumor cell for improving a treatment effect on the solid tumor. The polypeptide further comprises an ScFv structure of an anti-PD-L1 monoclonal antibody, and the CAR-T cells can simultaneously secrete a PD-L1 monoclonal antibody which interdicts an immunosuppressive action medicated by a PD1/PDL1 signal pathway and T cell failure, so that the treatment effect on the solid tumor is improved, the functional activity of immune cells in vivo is prolonged at the same time, and finally the tumor recurrence is retarded and even avoided.
Owner:HEBEI SENLANG BIOTECH CO LTD

A kind of polypeptide, nucleic acid encoding it, T lymphocyte modified by it and application thereof

The invention belongs to the technical field of biology, and discloses a polypeptide containing two chimeric antigen receptor structures, nucleic acid for coding the polypeptide, a modified T lymphocyte, and a preparation method and application of the T lymphocyte. The polypeptide provided by the invention contains the two chimeric antigen receptor (CAR) structures, wherein one chimeric antigen receptor structure specifically targets a tumor cell, and the other one specifically targets a normal B lymphocyte, so that a CAR-T cell is effectively amplified through recognizing the B lymphocyte ofa blood circulation system, and more CAR-T cells arrive at a solid tumor part so as to specifically kill the tumor cell for improving a treatment effect on the solid tumor. The polypeptide further comprises an ScFv structure of an anti-PD-L1 monoclonal antibody, and the CAR-T cells can simultaneously secrete a PD-L1 monoclonal antibody which interdicts an immunosuppressive action medicated by a PD1 / PDL1 signal pathway and T cell failure, so that the treatment effect on the solid tumor is improved, the functional activity of immune cells in vivo is prolonged at the same time, and finally the tumor recurrence is retarded and even avoided.
Owner:HEBEI SENLANG BIOTECH CO LTD

Composition containing plant chelating peptide and preparation method of composition

The invention belongs to the technical field of health care products, and particularly relates to a composition containing plant chelating peptide and a preparation method of the composition. The composition containing the plant chelating peptide, provided by the invention, is prepared from the following components in parts by weight: 280 to 520 parts of a natural compound extract, 10 to 30 parts of plant chelating peptide, 70 to 150 parts of probiotic powder and 350 to 400 parts of compound amino acid. According to the composition disclosed by the invention, the probiotic powder is combined with the plant chelating peptide, the composite natural extract and the composite amino acid, so that intestinal flora of a human body can be effectively regulated, absorption of nutrient substances is promoted, nutrient substances such as amino acid which cannot be generated by the human body can be supplemented, the immunity of the human body is enhanced, and physical fatigue is relieved; and meanwhile, heavy metals absorbed by the human body through a food chain are chelated, and the composition has a special absorption effect on the heavy metal cadmium Cd < 2 + >, thereby being safer to the human body, effectively playing a role in supplementing nutrition and expelling toxins. The composition is simple in preparation process and easy to popularize and apply.
Owner:英国纽歌芬生物科技国际集团控股有限公司 +1

Automatic testing tool for intermodulation of RF coaxial jumper wire assembly

An automatic testing tool for intermodulation of an RF coaxial jumper wire assembly comprises the components of a mounting base board, an axial pneumatic sliding table, a supporting board A, a cylinder, a supporting board B, a supporting frame A, a positioning block seat, a displacement sensor, sliding table cylinders, a pawl, a positioning block and a fixing frame. The supporting board A is mounted above the axial pneumatic sliding table. The supporting board A is connected with the supporting board B through the cylinder. The side surface of the supporting board B is provided with a displacement sensor. Furthermore two ends of the supporting board B are respectively provided with a sliding table cylinder. The pawl is mounted on the cylinder bodies of the sliding table cylinders. The supporting frame A and the fixing frame are mounted at two ends of the base board. The positioning block is mounted on the mounting block seat. The supporting frame A is used for supporting a jumper wire part of the jumper wire assembly. The fixing frame is used for fixedly connecting with a load block which is provided with a load lead. The automatic testing tool has advantages of ingenious design, reasonable layout, quick and reliable pneumatic control response, effective production efficiency increase, high social benefit and high economic benefit.
Owner:JIANGSU TRIGIANT TECH

A tool for automatic intermodulation testing of radio frequency coaxial jumper components

An automatic testing tool for intermodulation of an RF coaxial jumper wire assembly comprises the components of a mounting base board, an axial pneumatic sliding table, a supporting board A, a cylinder, a supporting board B, a supporting frame A, a positioning block seat, a displacement sensor, sliding table cylinders, a pawl, a positioning block and a fixing frame. The supporting board A is mounted above the axial pneumatic sliding table. The supporting board A is connected with the supporting board B through the cylinder. The side surface of the supporting board B is provided with a displacement sensor. Furthermore two ends of the supporting board B are respectively provided with a sliding table cylinder. The pawl is mounted on the cylinder bodies of the sliding table cylinders. The supporting frame A and the fixing frame are mounted at two ends of the base board. The positioning block is mounted on the mounting block seat. The supporting frame A is used for supporting a jumper wire part of the jumper wire assembly. The fixing frame is used for fixedly connecting with a load block which is provided with a load lead. The automatic testing tool has advantages of ingenious design, reasonable layout, quick and reliable pneumatic control response, effective production efficiency increase, high social benefit and high economic benefit.
Owner:JIANGSU TRIGIANT TECH
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