The invention relates to a tooth strap, rocking block and guide rod, and groove-shaped cam combined spatial mechanism of a sliding plug door, which relates to an open and close mechanism of sliding plug hermetization of a railway vehicle automatic door, in particular to the tooth strap, rocking block and guide rod, and groove-shaped cam combined spatial mechanism of the sliding plug door of a high-speed railway vehicle and other railway vehicles. The tooth strap, rocking block and guide rod, and groove-shaped cam combined spatial mechanism comprises a door frame, a motor, a driving wheel, a tooth strap, an auxiliary shaft, a lower strap clamp, a tensioning device, a bearing seat, a driven wheel, an auxiliary shaft sleeve, a rocking block, a guide rod, a load-bearing shaft, a load-bearing shaft sleeve, a rocking rod, a doorknob, a roller, a roller shaft, a groove-shaped cam and a door leaf, wherein a tooth strap transmission mechanism comprises the driving wheel, the tooth strap, the lower strap clamp, the tensioning device, the bearing seat and the driven wheel, and a rocking block and guide rod mechanism comprises the auxiliary shaft, the auxiliary shaft sleeve, the rocking block, the guide rod, the load-bearing shaft, the load-bearing shaft sleeve and the rocking rod; and a groove-shaped cam mechanism comprises the load-bearing shaft, the load-bearing shaft sleeve, the rocking rod, the doorknob, the roller, the roller shaft, the groove-shaped cam, the door leaf and the door frame, and the tooth strap transmission mechanism, the rocking block and guide rod mechanism and the groove-shaped cam mechanism are combined into the tooth strap, rocking block and guide rod, and groove-shaped cam combined spatial mechanism.