The invention discloses a manufacturing process of high-strength circular-drawing six-angle steel. The manufacturing process route sequentially comprises the steps of preparation of a blank material,surface cleaning, tip rolling, annealing and solid solution, blank lubrication, cold drawing, straightening, polishing and quality inspection and packaging, wherein a lubricant used for lubricating the blank material is a mixture of liquid paraffin, metal nano-powder and graphene oxide, the diameter of a die hole of a cold-drawing die is 6-14 mm, and the width of a diameter-fixed belt is 5-8 mm. According to the manufacturing process, cold drawing is adopted after surface lubrication treatment, so that the machining efficiency is improved, and the industrial amplification production requirements are met; and meanwhile, the cold drawing die hole is reasonably set, so that the deformation requirement is met, the drawing force is small, drawing is stable, the deformation is uniform, the drawing die is uniformly abraded, the size and the surface smoothness of a cold drawing material are ensured, then the cold-drawn steel has relatively high surface smoothness, and the requirement for the surface quality of the cold-drawn steel in the aerospace industry is met.