The device comprises a
lead alloy shielding box, the top end and the front side of the
lead alloy shielding box are both provided with openings, a
body position fixing mechanism is placed in the
lead alloy shielding box, and a local radiotherapy collimation mechanism is installed at the top end of the lead
alloy shielding box. The fixing mechanism comprises a plug board, a head fixing module, a limb fixing module and a
trunk fixing module, the local radiotherapy collimation mechanism comprises four vertical rods, a cross rod, a first multi-page lead
alloy collimator and a second multi-page lead
alloy collimator, and the first multi-page lead alloy
collimator and the second multi-page lead alloy collimator are vertically staggered in a horizontal-vertical mode. The
body position fixing mechanism adopts a fixed design of a plurality of modules such as a head, four limbs and a
trunk, ensures that a mouse keeps a stable
body position in the radiotherapy process, avoids errors possibly caused by slight movement in an
anesthesia state, not only improves the experiment precision, but also reduces the burden of repeated operation of researchers.