System and method for driving one or more cold-cathode fluorescent lamps. For example, the method includes generating at least one drive signal associated with a signal frequency, the signal frequency being equal to a first predetermined frequency, receiving a current-sensing signal, the current-sensing signal being associated with a lamp current for the one or more cold-cathode fluorescent lamps in response to at least the first predetermined frequency, and determining whether the current-sensing signal is larger than a first threshold in magnitude, the current-sensing signal being related to the first predetermined frequency. Additionally, the method includes, if the current-sensing signal related to the first predetermined frequency is determined to be larger than the first threshold in magnitude at anytime during a first period of time, changing the signal frequency from the first predetermined frequency to a second predetermined frequency, the second predetermined frequency being different from the first predetermined frequency.