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30 results about "Disorder lipid metabolism" patented technology

Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, waxes, and cholesterol. If you have one of these disorders, you may not have enough enzymes to break down lipids.

Peptides, derivatives and analogs thereof, and methods of using same

InactiveUS20070087971A1Promoting beta cell regenerationIncrease satietyOrganic active ingredientsSenses disorderHuman Proislet PeptideProgenitor
Human proIslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human proIslet Peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, and / or lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome.
Owner:CUREDM GRP HLDG

PPAR (Peroxisome Proliferator-Activated Receptor) gamma/delta dual agonist as well as preparation method and application thereof to medicine

The invention relates to a PPAR (Peroxisome Proliferator-Activated Receptor) gamma / delta dual agonist shown as a general formula (I), a preparation method thereof and application of a pharmaceutical composition containing the derivative to preparation of a medicine for preventing or / and treating abnormal glucose metabolism or / and abnormal lipid metabolism diseases. The PPARgamma / delta dual agonistprovided by the invention has excellent in vivo blood glucose lowering activity and blood lipid regulation effect, and can be used for preparing medicines for preventing or / and treating metabolic syndrome related diseases including diabetes mellitus, obesity, hyperlipidemia, atherosclerosis, fatty liver and the like; the PPARgamma / delta dual agonist has a wide application prospect. The formula (I) is shown in the description.
Owner:GUANGDONG PHARMA UNIV

Method of detecting lipid metabolic errors

InactiveUS20040101863A1Raise LDL levelMicrobiological testing/measurementGenes mutationFamilial hyperlipemia
The intended object of the present invention is to provide a more widely applicable means of diagnosing familial hyperlipemia with certainty. It has been found that this object can be attained by providing a method of detecting abnormality of lipid metabolism, wherein risk factors concerning abnormalities of lipid metabolism are detected on the basis of the correlation of 65 specific types of LDL receptor gene mutations with the abnormalities of lipid metabolism, as well as a method of detecting disease(s) by detecting risk factors for arteriosclerosis and / or ischemic heart diseases by employing as indices the abnormalities of lipid metabolism thus detected.
Owner:BML INC

Functional fat composition having effects of preventing cardiovascular and cerebrovascular diseases and diabetes risk factors

The invention belongs to the technical field of edible fit, and particularly relates to a functional fat composition having the effects of notably preventing cardiovascular and cerebrovascular diseases and diabetes risk factors, comprising disorder lipid metabolism, lipid peroxidation, and inflammatory factors. The functional fat composition having the effects of preventing cardiovascular and cerebrovascular diseases and diabetes risk factors is characterized by being prepared from the following raw materials in percentage by weight: 74.73%-93% of low erucic acid rapeseed oil, 6.0%-15% of krill oil, 0.16%-10% of vegapure plant sterol ester, 0.008%-0.07% of fat-soluble tea polyphenols and 0.02-0.2% of vitamin E. The composition notably strengthens the intervention effect of the fat composition to the cardiovascular and cerebrovascular diseases and the diabetes risk factors, and can be used as cooking fat or special diet edible fat for target populations.
Owner:INST OF OIL CROPS RES CHINESE ACAD OF AGRI SCI

Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof

InactiveCN101048402AUseful therapeuticUseful preventionOrganic active ingredientsOrganic chemistrySolventChemistry
A novel carbazole derivative which has the excellent functions of reducing the weight of fat tissues and lowering the blood sugar level and the blood lipid level. It is useful as a preventive / therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral fat, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver, or non-alcoholic steatohepatitis. It is a carbazole derivative represented by the following general formula (I). (In the formula (I), ring A represents phenyl, etc.; X represents -O-, etc.; Y represents =N-, etc.; a and b each represents methylene, etc.; V and Z each represents -O-, etc.; W represents C1-10 alkylene in which one or two hydrogen atoms may be replaced with phenyl or C1-5 alkyl, or represents 1,2-phenylene, 1,3-cyclohexyl, etc.; R<1> represents methyl, etc.; R<2> represents methoxy, etc.; and R<3> represents carboxy, etc.
Owner:ZERIA PHARMA

Docynia delavayi polyphenol extract and preparation method thereof

The invention discloses a Docynia delavayi polyphenol extract which has polyphenol content of 91.24 to 91.34% (w / w). The invention also provides a preparation method for the extract. With extraction conditions provided in the invention, polyphenol substances can be maximally extracted from Docynia delavayi, and an extraction rate is as high as 18.54%. High-purity polyphenol and phlorizin can be obtained by further purifying a crude extract with the purifying method provided by the invention. Pharmacological experiments show that the Docynia delavayi polyphenol extract can substantially reduce the levels of cholesterol TC, triglyceride TG, high-density lipoprotein HDL-C and low-density lipoprotein LDL-C in the serum of mice; thus, the Docynia delavayi polyphenol extract can effectively prevent and treat diseases related to abnormal lipids metabolism, such as obesity resulting from abnormal blood fat content, hyperlipidemia, atherosclerosis and coronary heart diseases.
Owner:SICHUAN NORMAL UNIVERSITY +1

A compound with ppar multiple agonistic activity and its preparation method and application

The invention discloses a compound with PPAR multiple agonist activities and a preparation method and application thereof. The compound has the chemical structure as shown in the formula I. Research results show that the compound adopting the formula I can remarkably improve the transcriptional activities of PPAR alpha, beta and gamma, has the multiple agonist activities of PPAR alpha, beta band gamma, is expected to serve as an active ingredient to be used for preparing a drug or health food for preventing and / or treating metabolic syndromes, and is particularly expected to be used for preparing a drug or health food for preventing and / or treating abnormal glucose metabolism and / or abnormal lipids metabolism diseases. The compound has a wide application prospect and a remarkable medicinal value.
Owner:SHANGHAI UNIV OF T C M

PPAR (peroxisome proliferator-activated receptor) alpha-gamma dual agonist and application thereof

The invention discloses a PPAR (peroxisome proliferator-activated receptor) alpha-gamma dual agonist and an application thereof. The PPAR alpha-gamma dual agonist contains an effective quantity of a derivative represented by the formula I or the formula II in the description and a pharmaceutically acceptable salt of the derivative, wherein definition of each substituent group is as claimed in theclaims and the description. Experiments prove that the compound represented as the formula I or the formula II can remarkably improve PPAR alpha-gamma transcriptional activity and mRNA level of related target genes, has PPAR alpha-gamma dual agonist activity and can be taken as an effective component of the PPAR alpha-gamma dual agonist. The PPAR alpha-gamma dual agonist can be applied to preparation of drugs and healthy food for preventing or / and treating metabolic syndromes, particularly can be applied to preparation of drugs and healthy food for preventing or / and treating abnormal glucose metabolism or / and abnormal lipids metabolism diseases, and has broad application prospect.
Owner:SHENYANG PHARMA UNIVERSITY

Pharmaceutical composition for suppression of the expression of ATP citrate lyase and use thereof

InactiveUS20050096367A1Elevated liver ACL expression of GK rats can be suppressedHigh indexBiocideOrganic active ingredientsFatty liverATP citrate lyase
The present invention provides a pharmaceutical composition for suppression of the expression of ATP citrate lyase, which contains a compound that suppresses the expression of ATP citrate lyase by the in vivo administration. The compounds suppress the expression of ATP citrate lyase by the in vivo administration include insulin secretagogues such as nateglinide. This pharmaceutical composition is effective in preventing, improving and treating metabolic syndrome, in particular, liver disorders related to abnormal lipid metabolism such as fatty liver and NASH.
Owner:AJINOMOTO CO INC

PPARgamma/delta dual agonist, preparation method thereof and application of PPARgamma/delta dual agonist as medicine

The invention relates to a novel PPAR gamma / delta dual agonist as shown in a general formula (I) which is described in the specification, a preparation method thereof and an application of a pharmaceutical composition containing the derivative in preparation of drugs for preventing or / and treating glucose metabolic disorder or / and lipid metabolic disorder diseases. The PPAR gamma / delta dual agonist has excellent in-vivo hypoglycemic activity and blood fat regulating effect, can be applied to preparation of drugs for preventing or / and treating metabolic syndrome related diseases such as diabetes, obesity, hyperlipidemia, atherosclerosis, fibrosis and fatty liver, and has a wide application prospect.
Owner:GUANGDONG PHARMA UNIV

Application of 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol in pharmacy

The invention discloses application of 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol in preparation of medicaments for inhibiting fatty liver and stabilizing atherosclerotic plaques. The dose of 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4,5-dihydro-1H-pyrazol-3-yl) phenol for effectively inhibiting the fatty liver and stabilizing the atherosclerotic plaques is 5-20mu g / kg / day. 4-chloro-2-(5-phenyl-1-(pyridine-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol provided by the invention lays a foundation for development of the medicaments for treating the fatty liver and arteriosclerosis and can be used as a powerful tool for researching a molecular mechanism of abnormal lipid metabolism and unstable atherosclerotic plaques.
Owner:SHANDONG UNIV

Animal having modification in mgat2 gene

It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.
Owner:MSD KK

Novel medical applications of notoginsenoside R2

InactiveCN111973609AOrganic active ingredientsMetabolism disorderDiseaseWhite Adipocytes
The invention discloses novel medical applications of notoginsenoside R2. The novel medical application comprises the application to preparation of drugs for preventing and treating obesity and type 2diabetes in mammals, the application to preparation of drugs for promoting browning of white adipocytes in mammals and the application to preparation of drugs for promoting generation of mitochondriain mammals. A new treatment method is provided for diseases related abnormal lipid metabolism such as obesity and type 2 diabetes.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI

Novel Cyclic Aminophenylalkanoic Acid Derivative

The present invention provides cyclic aminophenylalkanoic acid derivatives that act as agonists for human peroxisome proliferator-activated receptors (PPARs), in particular human PPARα isoform, and are effective in the treatment of abnormal lipid metabolism, diabetes and other disorders. The present invention also provides addition salts of such cyclic aminophenylalkanoic acid derivatives and pharmaceutical compositions containing these compounds.Specifically, the present invention provides cyclic aminophenylalkanoic acid derivatives represented by the following general formula (1):, or pharmaceutically acceptable salts thereof.
Owner:KYORIN PHARMA CO LTD

Novel Cyclic Amino Benzoic Acid Derivative

The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
Owner:KYORIN PHARMA CO LTD

Traditional Chinese medicine composition for treating level-1 and level-2 hypertension and preparation method of composition

The invention discloses a traditional Chinese medicine composition for treating level-1 and level-2 hypertension and a preparation method of the composition. The traditional Chinese medicine composition for treating level-1 and level-2 hypertension is characterized by comprising the following raw medical materials: ligusticum wallichii, rhizoma alismatis, semen raphani, seaweed and leech; and the traditional Chinese medicine composition is prepared through the steps of decocting, carrying out alcohol precipitation and the like for the raw medicinal liquid with the preparation amount. The traditional Chinese medicine composition has remarkable therapeutic effects on the level-1 and level-2 hypertension, not only reduces blood pressure, but also improves blood grease level of a patient and the hemorheology, increases a heart function, and is good for correcting disordered lipid metabolism of the patient. The preparation method is simple and good for production, and has no side effect.
Owner:INST OF BASIC RES & CLINICAL MEDICINE CHINA ACAD OF CHINESE MEDICAL SCI

Compound earthworm protein preparation for assistant adjustment of blood fat

The invention discloses a compound earthworm protein preparation for the assistant adjustment of blood fat. The compound earthworm protein preparation is composed of earthworm proteins, chitosan and selectable assistants. The preparation has a reasonable formula and substantial efficacies. Blood fat reduction assisting function examinations of the preparation, comprising animal tests of rats having disordered lipid metabolisms and human administration tests, are carried out by Nanjing Public Health Preventive Medicine Institute according to the Standard of Health Food Test and Assess (2003) published by the ministry of health, and results prove that the preparation has a blood fat reduction assisting effect. The preparation makes an attempt and a contribution to the application of traditional Chinese medicine earthworm in the healthcare food field.
Owner:珠海博康药业有限公司

Application of hydroxyprogesterone hexanoate in preparation of medicine for treating interstitial pneumonia

The invention provides application of hydroxyprogesterone hexanoate alone or combined with other medicines in preparation of medicines for treating interstitial pneumonia, a method for treating interstitial pneumonia, a corresponding medicine composition and the like. Hydroxyprogesterone hexanoate can relieve lung inflammation and fibrosis symptoms, reduce lung collagen deposition and reduce the levels of various inflammatory factors in alveolar lavage fluid and plasma. When the hydroxyprogesterone hexanoate and the dexamethasone are combined for use, abnormal lipid metabolism and the like caused by independent treatment of the dexamethasone can be improved.
Owner:SHENZHEN EVERGREEN THERAPEUTICS CO LTD

Inhibitor using plant cyclopeptide as effective component for lipid metabolic abnormalities in cancer cells and uses thereof

The present disclosure discloses an inhibitor for abnormal lipid metabolism of tumor cells with a plant cyclopeptide as an effective component, and discloses application of the inhibitor to preparation of drugs for inhibiting abnormal lipid metabolism of the tumor cells, which specifically can be applied to preparation of drugs for treating and preventing abnormal lipid metabolism related cancers including liver cancer, colon cancer, rectal cancer and prostatic cancer. The inhibitor for abnormal lipid metabolism of the cells of the present disclosure can effectively inhibit abnormal lipid metabolism of the tumor cells. Its effective component, the plant cyclopeptide, is wide in source and mature in extraction technology. The inhibitor has diversified dosage forms and medication ways and has a wide clinical application prospect.
Owner:CHINA PHARM UNIV

Compound with glucose-reducing and lipid-regulating effects as well as preparation and application thereof

ActiveCN112480047AImprove the immunityExcellent in vivo hypoglycemic and lipid-lowering activityOrganic active ingredientsOrganic chemistryFatty liverPharmaceutical drug
The invention discloses a compound with glucose-reducing and lipid-regulating effects as well as a preparation and application thereof. The compound with glucose-reducing and lipid-regulating effectsis a compound with structures as shown in a formula I and a formula II and a pharmaceutically acceptable salt, wherein the structures as shown in the formula I and the formula II are specifically shown in the specification. The preparation is a tablet, a capsule, powder, a pill or an injection prepared by adding pharmaceutically acceptable auxiliary materials into the compound with the glucose-reducing and lipid-regulating effects. The application is the application of the compound with the glucose-reducing and lipid-regulating effects in preparing an FFA1 / PPARdelta dual agonist. The application is the application of the compound with the glucose-reducing and lipid-regulating effects in preparation of drugs for preventing and / or treating glucose metabolic disorder and / or lipid metabolic disorder diseases. The compound and the medicinal salt thereof can be potentially used for treating or preventing diabetes, hyperlipidemia, fatty liver and other related metabolic syndromes, and have wide development prospects.
Owner:YUNNAN SECOND PEOPLES HOSPITAL +2

Composition of traditional Chinese medicine preparation for treating diabetes, its preparation method and application

ActiveCN109078150BHas the effect of promoting blood circulation and dredging collateralsQuality improvementMetabolism disorderUrinary disorderSalvia miltiorrhizaLiver and kidney
The invention belongs to the field of pharmaceutical preparations, and in particular relates to a composition of traditional Chinese medicine preparations for treating diabetes, a preparation method and application thereof. The composition of the traditional Chinese medicine preparation for treating diabetes, the composition is made of the main drug and auxiliary materials, the main drug is composed of the following components by weight: 10-20 parts of astragalus, 10-20 parts of rehmannia glutinosa, cornus officinalis 3-8 parts of meat, 6-10 parts of Chinese yam, 8-12 parts of curcuma, 3-8 parts of motherwort, 2-5 parts of salvia miltiorrhiza, 2-5 parts of rhubarb, the auxiliary materials are β-cyclodextrin and solid preparation auxiliary materials, The β-cyclodextrin is used to include the zedoary volatile oil to form the zedoary oil β-cyclodextrin inclusion complex, and the zedoary volatile oil is obtained by extracting the zedoary; the method for preparing the preparation provided by the present invention improves The quality of the product is improved and the industrialized production is easy; the obtained preparation conforms to the drug standard, has a good hypoglycemic effect, and can improve the heart, liver and kidney functions, abnormal lipid metabolism and retinal microvascular tumor lesions in mice.
Owner:TAIJI GROUP +1

Compound composition for lipid metabolism and prevention and treatment of fatty liver

The invention discloses a compound composition for lipid metabolism and prevention and treatment of fatty liver, which is characterized that the compound composition is formed by combining rhizoma polygonati and Chinese angelica according to a ratio of 1: 1. The rhizoma polygonati has the activities of regulating blood fat, regulating immunity, resisting aging and the like, the Chinese angelica has the activities of enhancing hematopoietic function, reducing blood fat, resisting thrombus, enhancing immunity and the like and is also used for preventing and treating lipid metabolism disorder diseases, and in addition, the nine-times refined rhizoma polygonati pills have the effects of resisting aging, resisting inflammation, enhancing immunity, enhancing bone marrow hematopoietic function, regulating glycolipid metabolism disorder and the like; therefore, the rhizoma polygonati and the Chinese angelica are compounded according to the ratio of 1: 1, and the compound can be used for regulating lipid metabolism and preventing and treating the non-alcoholic fatty liver disease.
Owner:YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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