The invention relates to a nondestructive detection method for the elastic modulus and the in plane shear modulus of a large-size wood based panel. The nondestructive detection method comprises: 1, placing a plate; 2, setting a measurement result storage directory and a file name, and inputting the basic parameters of the plate; 3, measuring the quality of the plate; 4, measuring the elastic modulus of the plate in a length direction, the elastic modulus of the plate in a width direction, and the in plane shear modulus; and 5, storing, and displaying the measurement result. According to the present invention, with the method, the main mechanical property indices such as the elastic modulus in the length direction, the elastic modulus in the width direction, the in plane shear modulus and the like can be nondestructively, quickly, conveniently and concurrently determined; and compared with the traditional detection method (small specimen bending measurement, tensile measurement, and the like), the method of the present invention has characteristics of non-destructive detection, time saving, cost saving, and convenient operation.