The invention discloses an intervertebral space opening device and a use method. The device is used for opening an intervertebral space in operations such as lumbar vertebra posterior-path spondylolisthesis reduction and bone graft fusion internal fixation. According to the scheme, the intervertebral space opening device comprises an intervertebral insertion and an opening clamp, the intervertebral insertion comprises an insertion body, a support part and a connector, and the opening clamp comprises a clamp head and a clamp handle; the support part is arranged at the rear end of the insertion body, the connector is arranged on the support part and used for being connected with the clamp head of the opening clamp, and the clamp head is provided with a groove matched with the connector. The intervertebral space opening device can easily and effectively open the intervertebral space, the inner width and the outer width of the opened space are similar, the phenomenon that the opened intervertebral space is narrow in front and wide in back can not occur, the problem that when an interbody fusion cage or a test mold is forcibly placed, end-plate fracture, interbody fusion cage collapse and the like occur is avoided, the operation process is accelerated conveniently for the operation, the operation time is shortened, the operation safety is improved, the success rate is increased, and then pain of patients is relieved.