37 results about "Rosacea flaccida" patented technology

Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein.

Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.

A method for the topical treatment of skin affected with acne, rosacea, or a combination thereof. Sodium chloride in a substantially pure form is topically applied to the affected skin by gently gliding the sodium chloride over the affected skin in a manner insufficient to cause abrasion and debridement of the affected skin. A solid block of about 98% to about 100% by weight sodium chloride free of a carrier and / or free of other topical acne-treatment medicaments and / or free of other topical rosacea-treatment medicaments should be used. The applied sodium chloride is left on the skin. Preferably, the affected skin is pre-moistened with water from shaving, bathing, splashing water on the skin, and the like prior to gliding the sodium chloride thereon.

Pharmaceutical / dermatological emulsions containing at least one avermectin compound, notably ivermectin, include at least one fatty phase and at least one aqueous phase, the at least one avermectin compound being solubilized in the fatty phase, which emulsions are useful for the treatment of a variety of dermatological conditions / afflictions, in particular rosacea.

The invention relates to a medicament for treating face acne, and particularly relates to a 'Miancuojing ointment' for treating acne diseases such as comedo, seborrheic dermatitis, rosacea, and the like. The medicament is prepared from metronidazole, chloramphenicol, borneol, sublimed sulfur, stearic acid, glycerin monostearate, lecithin, propylene glycol, triethanolamine, tween, distilled water and the like through process steps; the medicament of the invention has the effects of resisting propionibacterium acnes, dissolving skin cutin, and reducing skin free lipid, and has significant curative effects on acne (comedo), seborrheic dermatitis, and rosacea.

The invention discloses a traditional Chinese medicine spot removal skin whitening repair composition. The composition is prepared from, by weight, ginseng, bletilla striata, Moutan bark, Angelica sinensis, cinnamon, lucid ganoderma, pollen, cordyceps sinensis, silkworm larva, saffron crocus, golden cypress, licorice roots, lily, mulberry bark, bearberry and scutellaria baicalensis. The composition has the remarkable advantages that the curative effect is rapid, no toxic or side effect is caused, both symptoms and root causes are treated, skin diseases such as sores, furunculosis, acnes, tineacorporis, rosacea, fat granules, skin allergy pruritus, coupe rose skin, rhinitis sore-toxin and burning and scalding scars can be treated rapidly, and no damage is caused to skin; acne marks, scars,chloasma, butterfly rash, cyasma, senile plaque, sunburn, transmissibility plasue and sebum secretion unbalance are regulated, oily skin, blackheads and coarse pores are improved, cutting is digested, and the obvious curative effect is achieved for problem skin for achieving sun screen and skin tendering and whitening.

The invention discloses a traditional Chinese medicine composition for treating rosacea and a preparation method thereof. 20-30g of oriental wormwood, 20-30g of hawthorns, 20-30g of campsis grandiflora, 20-30g of red-rooted salvia roots, 20-30g of radix angelicae, 20-30g of wild chrysanthemum, 20-30g of cortex moutan radicis, 15-20g of fructus mume, 15-20g of white mulberry root bark, 15-20g of radix paeoniae rubra, 15-20g of red flowers, 15-20g of ligusticum wallichii, 15-20g of scutellaria baicalensis, 15-20g of jasmine and 5-10g of rheum officinale are weighed by weight, diluted with water, boiled and decocted, medicine liquid is taken orally two times every day, 250ml every time, ten days are in a treatment course, and during the treatment period, alcohol is forbidden, blind diet is combined. The traditional Chinese medicine composition for treating the rosacea is prepared by adopting the ordinary pure traditional Chinese medicines, is simple to prepare, low in cost and capable of effectively treating rosacea. The total effective rate for treating the rosacea is proved by clinical use to be more than 95%, and the rosacea does not relapse.

A composition for use in the treatment of rosacea includes a multi-kinase inhibitor that inhibits both a Vascular Endothelial Growth Factor Receptor and a Fibroblast Growth Factor Receptor. A method for treating rosacea for a patient includes inhibiting a Vascular Endothelial Growth Factor Receptor of the patient; and inhibiting a Fibroblast Growth Factor Receptor of the patient.

Disclosed are compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or dermatologic skin conditions. The compositions include black willow bark extract, cat's claw extract, and dragon's blood extract. The compositions ameliorate skin conditions including acne, rosacea, blemish, dermatitis, eczema, or the like.

The invention belongs to the field of Chinese herbal medicine and particularly relates to traditional Chinese medicine composition for treating rosacea. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of white mulberry root-bark, 10-15 parts of angelica, 5-15 parts of baical skullcap root, 5-15 parts of coptis chinensis, 5-15 parts of Chinese thorowax, 10-20 parts of trichosanthes root, 5-15 parts of dwarf lilyturf turber, 10-20 parts of honeyed folium eriobotryae, 25-35 parts of salvia miltiorrhiza, 25-35 parts of suberect spatholobus stem, 5-15 parts of rhizoma sparganii, 10-20 parts of zedoary, 5-15 parts of radix ranunculi ternati, 5-15 parts of edible tulip, 5-15 parts of notopterygium root, 10-20 parts of spreading hedyotis herb, 5-10 parts of dried orange peel, 10-20 parts of agastache, 5-10 parts of safflower, 5-15 parts of fructus forsythiae, 5-10 parts of angelica dahurica and 5-10 parts of honey-fried licorice root. The traditional Chinese medicine composition has the advantages that the cost is low, the formula is simple, the components are matched reasonably and effectively, the use is convenient, the efficiency is high, toxic and side effects are avoided, and the psychological burden and economic burden of patients are alleviated.

The invention discloses a traditional Chinese medicine external application composition for treating rosacea. The traditional Chinese medicine external application composition is characterized by comprising stemona, sulphur, realgar, sophora flavescens, cortex phellodendri, coptidis rhizome, radix scutellariae, cape jasmine, red peony roots, calomel, borneol and 75% ethyl alcohol. The traditional Chinese medicine external application composition for treating rosacea is scientific in compatibility, mites below the skin epidermis can be killed and eliminated, the red and swollen phenomenon of the nose can be released and eliminated, the traditional Chinese medicine external application composition is supplemented by the functions of clearing heat, detoxifying, promoting blood circulation and cooling blood to enable patients to recover, the traditional Chinese medicine external application composition is obvious in treating effect for treating rosacea, the sources of raw materials are abundant, the cost is low, the manufacturing method is simple, using is safe and convenient, the traditional Chinese medicine external application composition is free of side effects and easy to be accepted by the patients.

The invention discloses a Chinese medicinal preparation for treating rosacea, and the Chinese medicinal preparation is mainly used for treating the rosacea. The preparation is mainly prepared from 12 grams of root bark of white mulberry, 10 grams of loquat leaf, 15 grams of poria cocos, 12 grams of plantain seed, 15 grams of houttuynia, 12 grams of magnolia bark, figwort root, 18 grams of dwarf lilyturf tuber, 8 grams of pepperweed seed, 10 grams of gypsum, 18 grams of skullcap root, 8 grams of cooked rhubarb, and 12 grams of immature bitter orange. 1 dose of the medicaments is used every day, the medicaments are decocted with water, and the preparation is administrated after dinner. The residue for papule and abscess is decocted again, and the decoction is applied to the affected part. 15 days constitute a treatment course. The Chinese medicinal preparation for treating the rosacea is simple in formula and remarkable in treatment effect, does not have side effect, and is low in cost, convenient to administrate and convenient to popularize and apply.

The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of Phoenix dactylifera extract, tea tree oil, Myrothamnus flabellifolia extract, and saccharide isomerate. This combination can be used to create topical skin compositions that reduce rosacea, erythema, and / or inflammation, and inhibit nitric oxide synthase, increase α2A adrenergic receptor agonist activity, reduce oxidation, increase anti-oxidant capacity of a composition or of skin, inhibit cyclooxygenase-2 (COX-2) production, inhibit vascular endothelial growth factor (VEGF) production, inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) production, reduce tumor necrosis factor alpha (TNF-α) production, increase collagen stimulation, increase lysyl oxidase expression, inhibit matrix metalloproteinase 1 (MMP1) activity, increase occludin production, increase filaggrin production, and increase skin moisturization. This combination can also be used to reduce transient or persistent erythema, telangiectasia, inflammatory papules and / or pustules, transient or persistent flushing of the skin, and / or hyperplasia of a connective tissue.

The invention relates to a medicament for treating face acne, and particularly relates to a 'Miancuojing ointment' for treating acne diseases such as comedo, seborrheic dermatitis, rosacea, and the like. The medicament is prepared from metronidazole, chloramphenicol, borneol, sublimed sulfur, stearic acid, glycerin monostearate, lecithin, propylene glycol, triethanolamine, tween, distilled water and the like through process steps; the medicament of the invention has the effects of resisting propionibacterium acnes, dissolving skin cutin, and reducing skin free lipid, and has significant curative effects on acne (comedo), seborrheic dermatitis, and rosacea.

The invention discloses traditional Chinese medicine mask powder and a preparation method thereof. The traditional Chinese medicine mask powder is prepared from, by weight, 3-5 parts of radix angelicae sinensis, 5-7 parts of rhizoma dioscoreae, 2-3 parts of radix puerariae, 2-5 parts of periostracum cicada, 3-5 parts of pearl powder and 2-3 parts of silkworm larva. The preparation method of the traditional Chinese medicine mask powder comprises the following steps: drying, mixing, crushing and disinfecting the raw medicinal materials, and sieving with a 80-mesh sieve. Compared with the prior art, the traditional Chinese medicine mask powder has the advantages of being reasonable in composition, obvious in effect, small in dosage, green, environmentally friendly, healthy, capable of protecting skin, easy to operate, obvious in curative effect and small in side effect. The traditional Chinese medicine powder is mainly used for treating closed comedos, comedos, acnes, seborrheic dermatitis, rosacea, acne marks, pockmarks, pigmented spots, chloasma, freckles, dull yellow skin and excessive skin grease, and is capable of whitening and brightening the skin.

The invention relates to a pharmaceutical composition consisting of snail slime Helix aspersa muller (Cryptomphalus aspersus) (20% to 50%), camomile extract (1-4%), propolis 1l-4%), and pharmaceutically acceptable excipients and / or additives for forming a formulation of low, intermediate or high viscosity (10 to 1000 Pa-s). Said composition is in the form of a lotion, soap, cream or gel, which is embedded in a gauze-type fabric in the form of a plaster that can be applied to lesions caused by the different types of rosacea. The composition can also contain natural extracts such as marigold extract, honey and vegetable oils. The invention also relates to the method for producing the composition and to the use thereof for preparing a medicament or device for preventing, treating or curing lesions caused by rosacea, on the skin of the face or the body.

Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.

The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of Phoenix dactylifera extract, tea tree oil, Myrothamnus flabellifolia extract, and saccharide isomerate. This combination can be used to create topical skin compositions that reduce rosacea, erythema, and / or inflammation, and inhibit nitric oxide synthase, increase α2A adrenergic receptor agonist activity, reduce oxidation, increase anti-oxidant capacity of a composition or of skin, inhibit cyclooxygenase-2 (COX-2) production, inhibit vascular endothelial growth factor (VEGF) production, inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) production, reduce tumor necrosis factor alpha (TNF-α) production, increase collagen stimulation, increase lysyl oxidase expression, inhibit matrix metalloproteinase 1 (MMP1) activity, increase occludin production, increase filaggrin production, and increase skin moisturization. This combination can also be used to reduce transient or persistent erythema, telangiectasia, inflammatory papules and / or pustules, transient or persistent flushing of the skin, and / or hyperplasia of a connective tissue.

The invention belongs to the field of Chinese herbal medicines, in particular to a Chinese medicine composition for treating rosacea. The traditional Chinese medicine composition is made of the following raw materials in parts by weight: 10-20 parts of Cortex Mori, 10-15 parts of Angelica sinensis, 5-15 parts of Scutellaria baicalensis, 5-15 parts of Coptis Rhizoma, 5-15 parts of Bupleurum bupleuri, 10-20 parts of Trichosanthes 5-15 parts of Ophiopogon japonicus, 10-20 parts of broiled loquat leaves, 25-35 parts of Salvia miltiorrhiza, 25-35 parts of Caulis Spatholobus, 5-15 parts of Sanleng, 10-20 parts of curcuma, 5-15 parts of cat's claw 5-15 parts of Arrowhead Mushroom, 5-15 parts of Notopterygium, 10-20 parts of Hedyotis diffusa, 5-10 parts of Tangerine Peel, 10-20 parts of Huoxiang, 5-10 parts of Safflower, 5-15 parts of Lianzhao 5-10 parts, 5-10 parts of Angelica dahurica, 5-10 parts of roasted licorice. The traditional Chinese medicine composition of the invention has the advantages of low cost, simple formula, reasonable and effective component matching, convenient use and quick effect, no toxic and side effects, and reduces the psychological and economic burden of patients.

The invention relates to the identification of mircoRNAs associated with rosacea and to the uses thereof. More specifically, the invention relates to a method of diagnosing rosacea in a subject, comprising the determination, in a sample from said subject, of the expression of at least the combination of the following seven microRNAs: hsa-miR-3201, hsa-miR-4423-3p, hsa-miR-3128, hsa-miR-3163, hsa-miR-606, hsa-miR-4776-5p and hsa-miR-635.

The invention discloses a medicament for repairing skin and a preparation method thereof. The medicament comprises the following raw materials in part by weight: 0.9 to 150 parts of ginseng, 5 to 295 parts of bletilla, 20 to 300 parts of tree poney, 10 to 250 parts of Chinese angelica, 15 to 120 parts of cassia bark, 0.8 to 150 parts of glossy ganoderma and 0.5 to 150 parts of pollen. The preparation method comprises the following steps of: putting the raw materials into a container; adding water to flood the raw materials; decocting for 30 to 80 minutes hermetically or evaporating and decocting for 60 to 120 minutes; taking decoction out; adding the water to flood the raw materials; decocting hermetically or evaporating and decocting for the second time and the third time; mixing the decoction at three times; and packaging to form the medicament. The medicament achieves the effect of treating diseases such as skin allergy pruritus, blain scars, chloasma, butterfly rash, cyasma, senile plaque, sunburn, genetic freckles, fat granules, imbalance in sebum secretion, blackhead trichopore and the like which are caused by acnes, tinea corporis, acne rosacea, blood streak, hormone and the like safely and quickly under the synergistic action of the Chinese medicinal herbs.

A treatment for ocular rosacea using p38 and Erk kinase pathway inhibitors, which are believed to block the initial reaction to rosacea triggers and thus make it possible to prevent or minimize the skin reaction. The treatment is premised on a careful analysis of the alteration of cell-signaling pathways that facilitate the development of rosacea, which led to the identification of discrete targets for highly specific therapeutic intervention in the management of rosacea.

The invention belongs to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating rosacea. The traditional Chinese medicine composition is mainly prepared by proportioning, by weight, herb of circaea lutetiana L., radix asteris, rhizomes of sorghum propinquum, herb of fordiophyton fordii (Oliv.) Krass., leaves of Chinese littleleaf box, herb of stachys sieboldi Miq., rat kidneys, ground beetles and the like. According to the traditional Chinese medicine composition, a formula is reasonably formed by being in strict accordance with the etiology and pathogenesis of the rosacea according to the pharmacology and medicine properties of the bulk pharmaceuticals, all the components are proportioned reasonably and effectively, use is convenient, the effect can be rapidly achieved, no toxic or side effect exists, and the psychological and economic burden of a patient is reduced.

A composition for use in the treatment of rosacea includes a multi-kinase inhibitor that inhibits both a Vascular Endothelial Growth Factor Receptor and a Fibroblast Growth Factor Receptor. A method for treating rosacea for a patient includes inhibiting a Vascular Endothelial Growth Factor Receptor of the patient; and inhibiting a Fibroblast Growth Factor Receptor of the patient.

The invention discloses a traditional Chinese medicine effective part composition for treating rosacea and a preparation method thereof. The traditional Chinese medicine effective part composition is prepared by the following raw materials in parts by weight: siraitia grosvenorii, narcissus, salvia plebeian and fenugreek. The traditional Chinese medicine effective part composition provided by the invention can be prepared into medicine for treating rosacea, and has effects of clearing lung stomach and purging heat, clearing heat and removing toxicity, and activating blood and dissolving stasis, can be used for treating rosacea obviously, and has the advantages of no toxicity or side effects, and high security.

The invention relates to a traditional Chinese medicine preparation which is used for treating rosacea. The medicine is made from the materials according to the following weight account: 13 to15g for figwort root and rhubarb root each, 10 to 12g for garden burnet root, red peony root, raw cattail pollen, monkshoodvine root-bark and tongue herb of adder each and 7 to 8g for fineleaf schizonepeta herb. The invention is characterized by novel prescription, low cost, convenient preparation and remarkable effects.

Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.

A method of characterizing specific microbiota associated with Demodex mites from a rosacea patient is described. The method can include a step of realizing a biopsy on the patient and analyzing the microbiota based on a method of 16SrRNA sequencing or pyrosequencing. A method for the diagnosis of rosacea in a patient is also described. This method can include characterizing microbiota associated with Demodex mites in the patient. Also described, are methods of differentiating a subtype of rosacea in a patient with rosacea and methods of controlling and measuring an active agent's treatment effectiveness on rosacea.

The invention provides a preparation for treating acne and a preparation method of the preparation. The preparation comprises, by weight, 0.1-2 parts of metronidazole, 0.3-10 parts of aloe extracts, 5-20 parts of white vinegar, 0.2-5 parts of peppermint extracts, 0.1-3 parts of vitamin C and the rest double distilled water. According to the preparation, antisepsis and anti-inflammation functions are enhanced by the aid of the metronidazole and the white vinegar in the treating process of the acne, inflammation symptoms are effectively relieved, facial sympathetic nerves are stimulated by the aid of the vitamin C, so that the infected acne easily heals, and scar skins are effectively repaired to rehabilitate. In addition, the preparation is effective for other skin diseases such as rosacea, acne and tinea versicolor, has nursing and cleaning functions on the skins, has fewer components and is simple to prepare.