The invention relates to an integrated blockage removal agent used for uranium deposit seams, wherein, the integrated blockage removal agent is formed by the compounding of retarded acid, corrosion inhibitor, oxidative bactericide, surfactant and water according to a certain weight percentage. The blockage removal agent is formed by the following compounding method: firstly, under normal temperature, clean water is quantitatively added in a square pool; subsequently, under the mixing condition, according to the proportion, the corrosion inhibitor, the retarded acid, the surfactant and the oxidative bactericide are added in the square pool, wherein, according to the consistency, the retarded acid consists of 1 percent of hydrofluoric acid and 5 percent of acetic acid; the dosage of the retarded acid is 35-40 percent, the dosage of the corrosion inhibitor is 0.01 percent, the dosage of the bactericide is 0.01 percent and the dosage of the surfactant is 0.05 percent; and the clean water is added to the square pool till the consistency is 100 percent. The blockage removal agent has the effects of corrosion dissolution, sterilization and mechanical impurity and bacterium body disposal, eliminates the chemical deposits generated in the seams, effectively kills the bacteria and the microorganism, has the function of anti-fouling and improving the permeability of the seams, greatly prolongs the plugging period of the seams and improves the mining efficiency.