5 results about "Variant virus" patented technology

This invention relates to the field of pathogen detection technology, specifically to an intelligent adaptive virus detection and optimization method and system. The method includes: acquiring raw sequence data generated by probe capture sequencing; performing real-time analysis of the sequence data using a deep learning model, outputting analysis results including the virus's presence state and sequence characteristics; dynamically adjusting control parameters of the hybridization capture process based on the analysis results through an adaptive control system; and completing hybridization capture according to the adjusted parameters and outputting a detection report. The system includes a sequencing data acquisition module, an analysis module, a sensor data acquisition module, an adaptive control module, and a detection report generation module. This invention, by combining artificial intelligence analysis with real-time process control, achieves intelligent optimization of the virus detection process, significantly improving the accuracy, sensitivity, and adaptability of detection. It is particularly suitable for detecting highly variable viruses and low-viral-load samples, and has significant clinical application value.

The invention discloses an LSPR (Local Surface Plasmon Resonance) micro-fluidic chip system for rapid typing detection of various virus antigens, and particularly relates to the cross technical field of biomedical engineering, a micro-nano sensing technology, molecular diagnosis and micro-fluidic chip application. According to the present invention, by introducing the PEGylation anti-fouling layer and the BSA sealing treatment, the non-specific adsorption interference is effectively reduced, and compared with the problems that the traditional antigen rapid detection (Ag-RDT) is easily influenced by the virus epitope mutation and the variation is difficult to distinguish, the system can utilize the LSPR peak position red shift difference caused by the combination of different variation antigens and the specific antibody to achieve the precise typing of the multi-variant virus, meanwhile, white light dark field hyperspectral detection is combined with baseline correction, noise filtering and other algorithms, spectral signals can be accurately extracted, and even if interference components such as impurity protein and cell debris exist in a sample, feature signals of a target antigen can still be stably recognized.

The invention discloses a promoter with high strength and good orthogonality and application of the promoter in saRNA vaccines, and belongs to the technical field of synthetic biology and biology. A library of alpha replicase protein sub-promoters is constructed through sequence randomization, 20 sub-promoters with different intensities and orthogonality are obtained through screening, then the system is applied to regulation and control of expression of different antigen genes in cells, the time for reaching the titer (6-8 months) which cannot be neutralized for variant viruses can be slowed down and reduced, and the method has the advantages that the method is simple and convenient to operate, and the cost is low. Meanwhile, the multivalent self-amplification mRNA vaccine capable of effectively regulating spatiotemporal expression of multiple genes is obtained, and the research and development bottleneck of the multivalent self-amplification mRNA vaccine is broken through.

The present invention addresses the problem of providing: a new antigen that can also be effective against mutant viruses; and a new vaccine obtained by using said antigen. Said problem is solved by providing a lipopeptide which is obtained by conjugating a lipid and a peptide and in which the peptide has antigenicity and is represented by formula (1): a-b-c-d(-e-f)n. In the formula, n represents 0 or 1, and a-f include a specific amino acid.

The present application relates to a kind of compound shown in formula I or its pharmaceutically acceptable salt and its use, belong to the field of medicine.The compound or its pharmaceutically acceptable salt is high to the inhibition activity of SARS-Cov-2's Mpro main protease, low toxicity, good metabolic stability.The compound or its pharmaceutically acceptable salt can be used for the purpose of preparing the drug for inhibiting the Mpro main protease of SARS-Cov-2, and for the purpose of being used in the product for preventing, treating or reducing the replication or reproduction of coronavirus infection or its homologous variant virus and the cytopathic effect generated by it.