55results about How to "Avoid excessive frequency" patented technology

The present invention relates to an apparatus and method for rapid flash-like volatilization of high and low vapor pressure components from liquid or solid emanators which is in contact with a point or localized heat source. Vaporization is promoted by a geometrically small electrically resistive heating element with variable activation for pulsed or cyclic heating of an emanating surface containing the volatile components. The apparatus is primarily directed towards the treatment of residential air for fragrancing, odor elimination, treatment of insects or pests, air sanitization, air and surface antibacterial or antimicrobial treatment, or other ambient air or surface modification by way of gas or vapor distribution.

Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition of expression of α1,3-fucosyltransferase (FucT) and β1,2-xylosyltransferase (XylT) in a plant. Use of these constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a “humanized” N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.

The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Glycan-optimized monoclonal antibodies that specifically bind CD20 antigen and which have improved effector function are provided. The anti-CD20 antibodies of the invention have a glycosylation pattern that results in an antibody composition having predominately the G0 glycoform, and thus comprise N-glycans that lack fucose (i.e., afucosylated) and galactose residues attached thereto. In some embodiments, these anti-CD20 antibodies comprise the light chain and heavy chain sequences of the rituximab anti-CD20 antibody, and thus represent afucosylated rituximab. Methods for producing these glycan-optimized anti-CD20 antibodies are also provided.

The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions.The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

An image processor keeps itself capable of executing a communication process with an external apparatus even in an energy-saving state, and offers a job reservation function while reducing power consumption as much as possible. The image processor has an energization switching circuit that makes switchover separately in energizing / deenergizing each of a plurality of function blocks, which execute a job, independent of energization of an NIC. The NIC has functions of counting the present time, obtaining a scheduled time and reserved job information on a reserved job to be executed at the scheduled time, identifying the reserved job to be started for execution on the basis of a counted time and the scheduled time included in the reserved job information, and starting up a function block needed for execution of the identified reserved job through control over the energization switching circuit.

The present system proposes a technique called the spectro-temporal varying technique, to compute the suppression gain. This method is motivated by the perceptual properties of human auditory system; specifically, that the human ear has higher frequency resolution in the lower frequencies band and less frequency resolution in the higher frequencies, and also that the important speech information in the high frequencies are consonants which usually have random noise spectral shape. A second property of the human auditory system is that the human ear has lower temporal resolution in the lower frequencies and higher temporal resolution in the higher frequencies. Based on that, the system uses a spectro-temporal varying method which introduces the concept of frequency-smoothing by modifying the estimation of the a posteriori SNR. In addition, the system also makes the a priori SNR time-smoothing factor depend on frequency. As a result, the present method has better performance in reducing the amount of musical noise and preserves the naturalness of speech especially in very noisy conditions than do conventional methods.

The present invention relates to the use of a chemical composition to modify the physical properties (viscosity and interfacial tension) of heavy and extra-heavy crude oils, to increase their mobility. The chemical composition comprises or consists of a combination of systems based on ionic and non-ionic liquids, which may be pure or modified, mixed in an aqueous or organic medium as a dispersing agent, depending on the nature of the crude to be treated, together with a surfactant. The composition is mixed with the crude oil at a temperature between 5 and 100° C., at pressures from 1 atm (14.7 psi) up to about 680.2 atm (10,000 psi). The composition can be mixed with heavy crude oils, at the point of extraction from the well in the field, during the transport of crude oil in pipelines, or in the well discharge pipelines.

Disclosed is a catalyst for use in catalytic oxidation or ammoxidation of propane or isobutane in the gaseous phase, which comprises an oxide containing, in specific atomic ratios, molybdenum (Mo), vanadium (V), niobium (Nb) and antimony (Sb), wherein the oxide catalyst has a reduction ratio of from 8 to 12% and a specific surface area of from 5 to 30 m2 / g. Also disclosed is a process for efficiently producing this catalyst.

A method of building a set of experimental prediction model that requires fewer experimental frequency, shorter prediction time and higher prediction accuracy by using the advantages of combining the experimental data of Taguchi method and neural network learning is disclosed. The error between the experimentally measured result of photolithography and the simulated result of the theoretical model of near field photolithography is set as an objective function of an inverse method for back calculating fiber probe aperture size, which is adopted in the following Taguchi experiment. The analytical result of Taguchi neural network model of the present invention proves that the Taguchi neural network model can provide more accurate prediction result than the conventional Taguchi network model, and at the same time, improve the demerit of requiring massive training examples of the conventional neural network.

An apparatus and method for noise reduction is described. The method and apparatus can be used in a hands-free communication system to provide a hands-free a communication system having improved intelligibility. The apparatus includes a first and a second processor, each separately dynamically adapted to changing signals and noise, to improve a signal to noise ratio. The system and method can operate in the frequency domain and can have an interpolation processor to allow much of the processing to have fewer samples, and therefore, to occur more quickly. The method can also provide and store one or more adaptation vectors that can be used in operation of the system.

A method of reducing dust generation from an aggregate surface is described. The method includes applying a dust suppression compound to the aggregate surface. The dust suppression compound may be made from an aqueous mixture of an alkylcellulose compound and a halogen containing salt.

Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who are non-responsive ab initio to conventional TKI therapy. In various embodiments, the methods include administering to a patient a resistance-surmounting quantity of a TKI on a weekly or semi-weekly basis. Alternate embodiments of the present invention include a diagnostic method for assessing an individual's probability of being resistant to TKI therapy, based upon an expression level of epithelial membrane protein-1 (EMP-1); one of the genes believed to be responsible for TKI resistance. The methods of the present invention may be particularly useful in the treatment of lung, breast, prostate, ovarian, brain and colon cancers. The methods of the present invention may be effective in blocking the HER-2 kinase domain either in addition to or in lieu of blocking the EGFR kinase domain.

A ceramic cutting device having a base, longitudinal guides mounted to the base, and a support movably mounted on the longitudinal guides. A cutting-wheel handle holder is pivotably mounted to the support. A cutting-wheel handle is mounted to the handle holder and the cutting wheel is mounted to the handle. An actuating lever is mounted in a threaded hole in the handle holder so as to immobilize the handle so that the handle can apply pressure on a ceramic piece to be cut via the cutting wheel. The cutting wheel handle has an outer periphery with at least three longitudinally extended rebates which have a geometry that reduces the frequency of vibration during scoring of the ceramic piece by the cutting-wheel. The handle further has at least one longitudinally extending planar surface for engaging with the actuating lever.

Four blade VERTICAL AXIS WIND TURBINE is disclosed. Four equally radially spaced fixed troposkein shaped rotor blades nearly eliminates rotor torque ripple. Reduced rotor torque ripple allows thinner skin hollow cross section blades that are lighter and have higher frequency and lower stress natural vibrations. Improved single length blade extrusion has two integral mounting flanges at each of two root ends. One blade root flange is adjoined to the blade nose tip through a blade skin thickening gusset rail. One blade root flange is adjoined to the blade tail tip through a second blade skin thickening gusset rail. A third blade root flange forms a largely rectangular hollow between the two mounting flanges and the blade skin.A separable rectangular cross section blade hub is made from two hollow rectangular L-shaped cross section extruded beams. These L-shaped beams are cut from a single extrusion.

There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

An object of the present invention is to provide a whistle which has a resonance frequency shifted to the low-frequency side and a pleasant tone while retaining a compact size and light weight. In order to attain this object, a whistle comprises a mouthpiece portion, inside which an air passageway is formed and in which an air opening is opened, and a body portion, in which a connected resonance chamber that is connected to the air passageway is formed; the connected resonance chamber comprises a first resonance chamber, a second resonance chamber in which a sound-emitting opening is opened, and an orifice connecting the first resonance chamber and the second resonance chamber.

Vacuum insulating glass (VIG) units, edge seals for VIG units and methods for forming the edge seals are provided. The VIG units include an edge seal that includes a viscous material, which serves to restrict the rate at which gas permeates into a vacuum space defined between the glass sheets of the VIG unit. The edge seals are configured to allow the glass sheets to move laterally relative to one another when the glass sheets experience differential thermal strain and further configured such that viscous shear occurs within at least a portion of the viscous material when there is relative lateral movement between the glass sheets.

Disclosed herein is a device integrated in a piece of garment for providing abdominal support to a user comprising: an elastic band configured to wrap around a waist of the user and provide upward and inward physical support to an abdominal region of the user upon wearing; an interface configured to attach the elastic band to the piece of garment; at least one mechanically adjustable connection, wherein the mechanical adjustable connection is configured to adjust a length of the elastic band upon wearing; and an integration of the elastic band to the piece of garment, wherein the integration is configured to prevent at least a portion of the elastic band from directly contacting a body of the user upon wearing.

Disclosed herein is a device integrated in a piece of garment for the purpose of providing core abdominal and pelvic, or lower leg and foot support to a user comprising: an elastic band that wraps around a waist, a lower leg, or a foot of the user and provides upward and inward physical support to an abdominal and pelvic region, or lower leg and foot region of the user upon wearing; an interface that attaches the elastic band to the piece of garment; at least one mechanically adjustable connection, wherein the mechanical adjustable connection adjusts a length of the elastic band upon wearing; and an integration of the elastic band to the piece of garment, wherein the integration prevents at least a portion of the elastic band from directly contacting a body of the user upon wearing.

An image processor keeps itself capable of executing a communication process with an external apparatus even in an energy-saving state, and offers a job reservation function while reducing power consumption as much as possible. The image processor has an energization switching circuit that makes switchover separately in energizing / deenergizing each of a plurality of function blocks, which execute a job, independent of energization of a Network Interface Card (NIC). The NIC has functions of counting the present time, obtaining a scheduled time and reserved job information on a reserved job to be executed at the scheduled time, identifying the reserved job to be started for execution on the basis of a counted time and the scheduled time included in the reserved job information, and starting up a function block needed for execution of the identified reserved job through control over the energization switching circuit.

A refrigerator of the present invention includes a Rankine cycle heat engine and a refrigeration cycle heat engine which share a condenser, and drives a compressor of the refrigeration cycle by an expander of the Rankine cycle. A screw expander and a screw compressor are set up within a common casing, and the exhaust side of a rotating shaft of the screw expander is connected to the discharge side of a rotating shaft of the screw compressor. Preferably, an intermediate space in which an exhaust passage of the screw expander and a discharge passage of the screw compressor are merged together and connected to a condenser, and a coupling which connects the rotating shaft of the screw expander to the rotating shaft of the screw compressor is housed is formed within the casing.

The present invention has an object to provide a fuel-saving driving system which gradually decreases a target vehicle speed from start of control to passage of a descending-slope starting point in a linear form and can obtain fuel-saving and smooth driving feeling without repeating fuel-cut and injection.The present invention has a vehicle-position specifying device (2) for specifying the position of a vehicle, a storage device (11) for storing data of a descending slope located in the vehicle traveling direction, a vehicle speed measuring device (3) for measuring a speed (Va) of the vehicle (1), and a controller (10), the controller (10) has a function of determining (calculating) a target speed (requested speed Vd) of the vehicle (1) from the vehicle speed (Va) and the data of the descending slope.

Systems and methods for phase detection are disclosed. A collapsible three-stage pipeline includes a first register in a first stage having a first clock signal having first clock edges, a second register in a second stage that receives a first signal from the first stage, and having a second clock signal having second clock edges, and a third register in a third stage that receives a second signal from the second stage, and having a third clock signal having third clock edges, wherein each second clock edge has a corresponding first clock edge and a corresponding third clock edge. The circuitry may further include a two-stage pipeline including fourth and fifth stages, a counter that provides an input signal into the collapsible three-stage pipeline and the two-stage pipeline, and a comparator that compares a first output of the collapsible three-stage pipeline and a second output of the two-stage pipeline.

A head block assembly (105) comprising a first head block (120) having a first pair of cable engaging sheaves (130); a second head block (125) having a second pair of cable engaging sheaves (135); a separation device (140) mounted intermediate the first and second head blocks (120, 125), for effecting relative transverse movement of said head blocks; wherein the first pair of sheaves (130) are selectively disengagable from the first head block (120), and selectively engagable with the second head block (135).

A method is applicable to an LCD for transmitting control signals and pixel data signals to source drivers. First, control signals are transmitted to each of source drivers in parallel during a control period. Pixel data signals for driving a horizontal pixel line are transmitted to each of the source drivers in parallel during plural pixel data periods. The control signals and the pixel data signals are transmitted through a same set of channels connected to each of the source drivers according to a pixel clock signal.

An electronic control unit (ECU) obtains outside air humidity information from a sensor disposed outside a vehicle compartment and inside air humidity information from a sensor inside the vehicle compartment. The ECU includes a humidity information obtainer obtaining the inside air humidity information, a humidity change calculator calculating the inside air humidity information as a difference between (i) a physical quantity correlated with humidity before a start of a dehumidification or a humidification and (ii) a physical quantity correlated with humidity after a switch-off of the dehumidification or the humidification, a soak time calculator calculating, based on the difference of the physical quantities, a soak time from the switch-off of the dehumidification or the humidification to a sensor-diag startable time at which a diagnosis of the outside air humidity sensor is startable, and a comparator comparing the outside air humidity information and the inside air humidity information after a lapse of the soak time from the switch-off of the dehumidification or the humidification.

A method is applicable to an LCD for transmitting control signals and pixel data signals to source drivers. First, control signals are transmitted to each of source drivers in parallel during a control period. Pixel data signals for driving a horizontal pixel line are transmitted to each of the source drivers in parallel during plural pixel data periods. The control signals and the pixel data signals are transmitted through a same set of channels connected to each of the source drivers according to a pixel clock signal.