The invention relates to the technical field of drug monitoring and storage, and discloses a drug monitoring and storage device. The drug monitoring and storage device comprises a cabinet body, a display screen, multiple keys, an authentication device, a camera, a barcode scanner, a drug storage box, and a control system; the display screen, the multiple keys, the authentication device, the camera, and the barcode scanner are arranged on the front side of the upper part of the cabinet body, the drug storage box is arranged on the lower part of the cabinet body, an electric box door is arrangedon the front side surface, located on the cabinet body, of the drug storage box, the control system comprises a single chip microcomputer, a wireless communication module and a power supply module, the power module is used for providing power for the whole device, the display screen, the multiple keys, the authentication device, the camera, the electric box door, the barcode scanner, and the wireless communication module are connected with the single chip microcomputer. The drug monitoring and storage device facilitates people to reflect adverse drug reactions, the drug quality can be monitored and managed, drugs with adverse reactions are timely recalled, and people health is certainly guaranteed.