The invention discloses a fumigation agent for weight-losing and skin whitening and a preparation and using method thereof; the weight percentage of raw materials is as follows: 0.5-0.8% of saffron crocus, 0.5-0.8% of glossy ganoderma, 0.5-1% of Jinluohan (a kind of Tibetan medicines) , 8-10% of sarmentose pepper herb, 10-12% of passiflora perpera mast., 10-12% black bark maple, 10-12% of large bark maple, 3-8% of mahonia ganpinensis, 3-8% of watermelon pilea, 3-5% of polygonum cuspidate, 5-10% of mucuna macrocarpa and 40-45% of stone needle. The medicinal materials are soaked, boiled under high pressure and concentrated to obtain the fumigation agent which is put in a vapor generating vessel, then the generated vapor is conducted into a container, and the temperature is adjusted to 45-60% for use. The fumigation agent can facilitate weight losing and skin whitening; in addition, the fumigation agent also has excellent effect for preventing and treating rheumatism, rheumatoid arthritis, cervical spondylosis, scapulohumeral periarthritis, hyperosteogeny, talalgia, exogenous wind-cold, stiff neck, insomnia, air conditioning diseases, etc.