A radiation-resistant flip-flop circuit structure based on a single-phase clock, including a clock generation module, a data filtering module, a first single-phase clock basic flip-flop module, a second single-phase clock basic flip-flop module, a third single-phase clock Bit clock basic trigger module, first DICE hardening module, second DICE hardening module, third DICE hardening module, first C-unit module, second C-unit module, third C-unit module and election module. The flip-flop circuit structure of the present invention adopts single-phase clock technology. Compared with the existing flip-flop technology, it not only saves the area cost and reduces power consumption, but also avoids the timing redundancy in the flip-flop of the master-slave structure, and improves the efficiency of the flip-flop. Timing performance, in addition, the trigger circuit structure of the present invention adopts a hybrid DICE+TMR structure, which improves the trigger pulse of the trigger and enhances the ability to resist single event reversal and single event pulse.