The invention relates to a combined driving micro-displacement regulation device, which consists of a worm gear and worm drive module, a worm gear shaft, a rotating shaft, a key, a rolling bearing, a grating ruler, a bearing retainer, a slide block, a shell, a third oil cylinder, a hydraulic drive module, a worktable and a drive control system, wherein the worm gear shaft is fixedly connected with the worm gear and worm drive module through a screw; one end of the rotating shaft is connected with the worm gear shaft and the other end of the rotating shaft is connected with a nut screw thread pair; the rotating shaft is positioned in the rolling bearing; the bottom end of a nut is in rigid connection with the slide block; the slide block linearly reciprocates along a guide rail; the right end of the nut is provided with an equivalent piston and is connected with the third oil cylinder; the third oil cylinder is positioned in the shell and is communicated with an oil cylinder of the hydraulic drive module through a hydraulic circuit; a piston of the hydraulic drive module is connected with the worktable; the grating ruler is arranged on the worktable; and the worm gear and worm drive module consists of a motor, a motor bracket, a coupler, a worm-gear case, a first radial bearing, a first retainer ring, a second radial bearing, a second retainer ring, a worm gear and a worm. By the device, precise displacement of the worktable can be regulated, stable displacement regulation is realized, and a reduction ratio of static hydraulic drive is regulated.