34results about How to "Reduce tendency" patented technology

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, "aversive" experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

This invention relates to methods and reagents for selectively labeling membrane surface proteins using a labeling agent. The label may be used to isolate preparations of membrane surface proteins. Preparations of membrane surface proteins may be analysed by a variety of high-throughput techniques to allow rapid profiling of membrane surface protein composition.

A coaxial cable connector generally includes a connector body, a nut rotatably coupled to the connector body, a post disposed in the connector body and a biasing element acting between the post and the nut. The nut has an internal thread for engagement with an external thread of a mating connector. The internal thread of the nut and the external thread of the mating connector can be mismatched, wherein an interference fit is created therebetween upon connection of the nut to the mating connector. Also, the post can have a forward flanged base portion disposed within the axial length of the internally threaded surface of the nut, which, together with the biasing element, provides a constant force between the post and the nut.

Methods for depositing an overlay coating on articles intended for use in hostile thermal environments. The coating has a predominantly gamma prime-phase nickel aluminide (Ni3Al) composition suitable for use as an environmental coating and as a bond coat of a thermal barrier coating system. The coating further contains at least one platinum group metal, preferably chromium, optionally one or more reactive elements, and optionally silicon. The coating is deposited by a process that entails forming a platinum group metal layer and at least one separate layer of other constituents of the coating, and then performing a diffusion heat treatment to yield the coating.

A connector for making an optical connection underwater or in a wet environment, including first and second connector parts adapted to be interengaged, the first connector part having a probe and the second connector part having a chamber containing fluid media. The probe has a forward portion for entry into the chamber of the second part containing fluid media during interengagement of the connector parts, so that when the connector parts are interengaged the probe provides an optical path between the first connector part and the chamber of the second connector part and passing into the chamber of the second connector part at a slant to the axial direction. The probe slides axially through the opening in sliding engagement with a seal and continues to do so as the forward portion of the probe advances into the chamber containing fluid media.

A faux-shirt girdle for use to shape and support the abdomen of a user while also serving to substantially cover a user's midriff and lower back regions is discloses. The girdle comprises a girdle portion and a shirt portion coupled to the bottom of the girdle portion. The girdle portion is configured to provide support to the user's abdomen region. The shirt portion is configured to cover the user's midriff, and to reduce migration of the lower portion of the girdle portion toward the user's chest line. The shirt portion attached to the bottom of the girdle portion and an elastic or resilient band attached to the top of the girdle portion both work to reduce migration or bunching of the girdle portion around the middle of the torso. The shirt portions can be made of any fabric and can be tucked into, or worn over, a user's other external clothing layer.

A method for producing hydrogen gas is provided comprising selecting a bacteria from the Order Thermotogales, subjecting the bacteria to a feedstock and to a suitable growth environment having an oxygen concentration below the oxygen concentration of water in equilibrium with air; and maintaining the environment at a predetermined pH and at a temperature of at least approximately 45° C. for a time sufficient to allow the bacteria to metabolize the feedstock.

High flow rate catheters, and related methods, are useful in dialysis and other procedures. A catheter according to the invention comprises a hub and a generally elongated conduit. The conduit has a substantially continuous and smooth wall. The conduit also defines at least one lumen and has a length extending from a proximal end to a distal end of the conduit. The proximal end is coupled to a hub and the distal end has an opening in communication with the lumen. The conduit has a conical shape which tapers along the length.

A comminution apparatus for reducing a particle size of a material includes a cutting chamber defining an interior volume, wherein the cutting chamber includes first and second member forming an angle therebetween. Each of the first and second members include a plurality of slots therethrough providing access to the interior volume. The apparatus further includes a rotatable arbor disposed outside the interior volume of the cutting chamber and supporting a plurality of toothed blades thereon. During rotation of the arbor a portion of each of the blades enters an interior volume of the cutting chamber through the slots in the first member and exits the interior volume of the cutting chamber through the slots in the second member. The comminution apparatus may be used to process various feed materials to desired sizes, and is particularly useful for reducing the size of materials otherwise difficult to cut to small size. Such materials include, for example, zirconium, titanium, magnesium, niobium, calcium, copper, potassium, hafnium and aluminum

A magnetic resonance sequence model that is a formal description of a measurement sequence is used to automate measurement sequence programming. The sequence model allows a system-independent specification of the measurement sequence for execution in a magnetic resonance scanner. The sequence model is as formal as possible; it is limited to the minimum required information for description of a measurement sequence without limiting the flexibility in the sequence programming. A method for formal description of the measurement sequence describes the measurement sequence by a number of parameters to be parameterized. The parameterization of the measurement sequence can ensue automatically from the formalized description of the measurement sequence, except for a set of parameters that are still be determined. For automatic generation of an executable measurement sequence, the method determines the parameters to be determined using a solver, under consideration of boundary conditions, so that a consistent set of parameters is created that completely describes the measurement sequence. This complete description of parameter values of the measurement sequence is then be translated automatically into a programming language that can be directly executed in the magnetic resonance scanner.

Inlet guide vanes and gas turbine engine systems involving such vanes are provided. In this regard, a representative an inlet guide vane for a gas turbine engine includes: a fixed strut; and a variable flap located downstream of the fixed strut and being movable with respect thereto; the fixed strut having a leading edge, a trailing edge and side surfaces extending between the leading edge and the trailing edge, the side surfaces being asymmetric with respect to each other.

A discharging device for liquids.The invention relates to a discharging device for liquids, more particularly for pharmaceutical liquids, comprising a delivery device (10), a liquid storage receptical (20) communicating with an input (10a) of the delivery device for storage of the liquid (30), and a discharge orifice (12) which communicates with an outlet (10b) of said delivery device,and the liquid storage receptical (20) is at least in part in the form of a dimensionally flexible liquid-containing bag (20) and the liquid storage receptical (20) is disposed in a buffer chamber of constant volume (42).To prevent air from escaping from the buffer chamber (42), provision is madefor the buffer chamber to be sealed by a protective housing from the environment (1) in a gas-tight manner,for the buffer chamber to communicate with the environment through at least one capillary passageway for the purpose of pressure compensation, orfor the buffer chamber (42) to communicate with the environment (1) via a balancing passageway for the purpose of pressure compensation, while a valve (70) which opens in dependence on the pressure differential is disposed in this balancing passageway.

The present disclosure relates to guidewire devices having shapeable tips and effective torquability. A guidewire device includes a core having a proximal section and a tapered distal section. A tube structure is coupled to the core such that the tapered distal section of the core extends into and distally beyond the tube structure. The portion of the core extending distally beyond the tube forms a shapeable tip. A polymer covering encompasses the tip. The tip is configured to reduce the tendency of resilient forces from the tube structure to disrupt a customized shape of the tip.

In a vacuum pumping system with a plurality of sputter ion pumps the considerable reduction in its overall axial size and weight is achieved by utilizing a plurality of axially superimposed sputter ion pumps and a common magnetic circuit, which comprises a pair of external magnets located at opposite axial ends of the pumping system, one or more intermediate magnets arranged alternated with the sputter ion pumps and a ferromagnetic yoke, internally enclosing the external magnets and the one or more intermediate magnets.

An aerofoil blade or vane (1) suitable for the turbine of a gas turbine engine includes a longitudinally extending aerofoil portion (7) having facing wall parts (20, 22). The wall parts being interconnected by a generally longitudinally extending divider member (17) to partially define first and second cooling fluid passage portions (11, 15) disposed in side-by-side generally longitudinally extending relationship. The first and second passage portions being interconnected in series fluid flow relationship by a bend passage portion (13). The first passage portion is adapted to direct cooling fluid to the bend portion and the second passage portion being adapted to exhaust cooling fluid from the bend portion. The divider member has a first local thickening (33) in the region of the bend portion to provide a localised contraction of the downstream end of the first passage portion to accelerate the cooling fluid flow before it enters the bend passage portion. The divider member has a second local thickening (31) in the region of the bend portion to provide a localised progressive series narrowing and opening of the upstream end of the second passage portion in the general direction of cooling fluid flow.

Provided is a method for styling mammalian hair that includes contacting the hair with a composition that includes a poly(vinylamine-vinylformamide) copolymer and a first carrier, contacting the hair with a composition that includes a citrate and a second carrier, and styling the hair. The method of the present invention promotes improved hair styling properties such as improved curl retention and straightness retention, e.g., under conditions of high relative humidity and temperature. The method can be used for semi-permanently straightening or curling the hair. Also provided is a method for controlling fizz by applying the copolymer and citrate compositions.

A calendar slide for binding a margin of a calendar or a poster and allowing the same to be hung by a hanger in a desired location, such as a wall. Spaced convex bulges in the calendar slide prevent the slides from sticking together during the storage, shipment, and binding processes, and also promote uniform stacking of the slides in a tinning machine magazine, and finally prevent the adjacent nested slides from scratching or marring one another.

A trailer assembly for use with a towing vehicle such as a dump truck. The assembly comprises a pup trailer that has a fixed or a terminally-steerable front axle and an adjustable length tongue that secures the trailer to the towing vehicle. The trailer and tongue are secured to each other by a pivot that has a single lateral axis. The pivot permits vertical pivoting of the trailer and tongue relative to each other through a range of motion that is as much as forty degrees above and below the horizontal. The pivot resists lateral pivoting motion between the tongue and trailer. The assembly permits the trailer to be easily towed over uneven terrain and resists the tendency of the trailer to tip during towing and during dumping.

A tape dispenser for young children. The dispenser includes first and second sides that are formed in the shape of an animal and more particularly in the shape of a turtle or snail. The first and second sides are connected together to form a chamber into which a roll of tape is inserted. Each of the first and second sides includes an end portion that is enlarged. A cutter blade is mounted between the enlarged end portions and is positioned a spaced distance inwardly from an outer edge of each end portion. The upper and outer walls of the dispenser include a plurality of ridges to aid in the gripping of the dispenser. The ridges are shaped and positioned to represent the shells of either a turtle or a snail.

A system for reducing implement wheel forces on a field surface has an agricultural implement with a frame mounted on frame wheels and ground engaging tools mounted on the frame. When the ground engaging tools move down to penetrate the field surface they exert an upward tool force on the frame. Support arms are movably connected to the implement frame and a support wheel is rotatably mounted to each support arm. A support bias element exerts a support bias force on each support arm to force the support wheel against the field surface and to correspondingly force the implement frame upward, transferring a supported frame weight from the implement frame to the support wheels, such that an unsupported frame weight is carried on the frame wheels. A bias control varies the support bias forces to maintain the unsupported frame weight at a level greater than the upward tool force.

A composition for preventing or retarding the formation of gas hydrates or for reducing the tendency of gas hydrates to agglomerate, during the transport of a fluid comprising water and a hydrocarbon, through a conduit, comprising, (a) a polymer which is a homopolymer of N-vinyl caprolactam, or a copolymer of N-vinyl caprolactam, with a comonomer, e.g. N,N-dialkyl-aminoethyl(meth)acrylate, and (b) a synergistic additive therewith which is a cationic or non-ionic surfactant, or a sugar, and mixtures thereof.

The present invention reveals a device, a kit and a method for simultaneously delivering and distributing at least one beneficial agent to both the cervical and vaginal lumen sides of a vagina. The device is made of a flexible circular rim and a flexible dome. The device can exist in either a relaxed state or in a compressed state. In the compressed state, pouches are formed for carrying and delivering the beneficial agent to both the cervical and vaginal lumen sides of the vagina.

A footwear-insole for modifying a user's gait configured to extend under a user's foot and provide greater than 0 to 5.0° dorsiflexion support and greater than 0 to 5.0° eversion support.

An injection mixer is provided, which includes an injection module, a valve seat module, and an adjusting module. The injection module may be disposed to penetrate one end of a bucket container. The valve seat module may be disposed at the end of the injection module, and the valve seat module may be disposed with at least one fluid supply channel and at least one outlet channel. The adjusting module may be disposed at the valve seat module to penetrate therethrough. The adjusting module may be movably connected to the injection module. When the adjusting module is driven to move the injection module towards or away from the valve seat module, an annular protrusion may approach or move away from the inner wall of the bucket container, and a size of the predetermined gap may be reduced or increased.

A self-supporting field director structure for use in heating an article in a microwave oven is characterized by a vane array comprising a plurality of V-shaped vane doublets, wherein each vane doublet itself comprises a first and a second vane. Each vane extends radially outwardly from the central axis. Each vane has a substrate formed from an electrically non-conductive material, with a portion of each vane being electrically conductive. A vane support structure is attached to the vane array.

A garment comprises a neck opening for receiving a neck of a wearer and a supportive inner layer having a body portion and a pelvic portion. The pelvic portion includes leg openings for receiving a respective leg of a wearer and a crotch portion extending between the leg openings. At least one of the body and pelvic portions includes an elastic material to impart compression on a wearer. The garment also comprises a decorative outer layer, with the inner layer attached to the outer layer only at or adjacent to the neck opening. The outer layer is made from a different material to that of the inner layer and does not impart compression on the wearer.

An electrical connector includes contact pads on a printed circuit board and contact members on a substrate. The contact members are pressed against the contact pads by a compression mat having compressor fingers. A clamping arrangement forces the compressor fingers against the substrate and thereby presses the contact members against the connector pads. The compression mat is made of elastomeric material, which has a tendency to relax and thus reduce the pressure after the clamping arrangement is tightened. A restrainer member is used to offset this tendency of the polymer to relax. The restrainer member has holes through which the compressor fingers of the compression mat extend.