The present invention provides a kind of ore dressing process and application of using composite collector to separate monazite and rutile, said ore beneficiation process includes the following steps: (1) by weight, 10 to 15 parts of tall oil, 25 parts of oxidized paraffin wax soap ~35 parts, palm oil 40~50 parts, sodium fatty acid methyl ester sulfonate 10~15 parts, microwave preactivation 5~10min; Saponification for 1.5 to 2.5 hours to obtain the target collector; (2) Take the rutile crude concentrate raw material, add the above-mentioned collector, inhibitor, activator, and foaming agent, and perform the first flotation to obtain monazite Coarse concentrate and tailings; (3) add monazite coarse concentrate to the above-mentioned collector, inhibitor, activator, foaming agent, and carry out the second flotation to obtain monazite concentrate and tailings, the tailings The mine is rutile concentrate. The beneficiation process of the invention effectively separates the rutile rough concentrate to obtain monazite concentrate products and rutile concentrate products with high quality and is environmentally friendly.