The invention belongs to the technical field of sanitary disinfection equipment, and relates to an automatic hand disinfection device. A main structure includes a disinfection cover, a first front baffle, a second front baffle, a first track, a first sliding block, a first lead screw, a first motor, a second motor, a movable plate, a movable plate front baffle, a second track, a second sliding block, a second lead screw, a third track, a third sliding block, a fourth track, a fourth sliding block, a finger support, finger separating blocks, sensors, a first upper spray nozzle, a second upper spray nozzle, a first lower spray nozzle, a second lower spray nozzle, a first liquid storage device, a second liquid storage device, a first piston pump, a second piston pump, a controller, a starting switch, a first waste liquid outlet, a second waste liquid outlet and a waste liquid storage device; and left four finger separating blocks and right four finger separating blocks on a finger support cross beam are symmetrically arranged, and are used for separating fingers for certain distance; The automatic hand disinfection device is ingenious in overall structural design, scientific in principle, safe, reliable, high in universality, convenient to operate and popularize and friendly to application environment.