41 results about "Araneosene" patented technology

The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

The present invention relates to a process for the regioselective synthesis of compounds of the formula I,wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

The invention discloses macrocyclic and cage-like molecules based on biphenylarene and derivatives of the macrocyclic and cage-like molecules as well as synthetic methods and applications of the macrocyclic and cage-like molecules and the derivatives. A series of novel macrocycles are obtained mainly by performing a reaction on bis(2,4-dialkoxyphenyl)arenes (naphthalene, anthracene, pyrene, porphyrin and the like) or tris(2,4-dialkoxyphenyl)arenes (benzene, sym-tribenzobenzene) and paraformaldehyde under the catalysis of a Lewis acid in high yield. In addition, perhydroxybiphenylarenes (quaterphenyl trimer, naphthalene dimer and the like) can be obtained by performing demethylation, a plurality of water-soluble derivatives can be obtained by performing further modification, and the derivatives show good bonding ability to guest molecules (viologen and the like); and moreover, functional groups introduced into the framework make the biphenylarene have excellent adsorption and separationability and photophysical properties. The compounds, derivatives and methods provided by the invention have the following advantages: raw materials of the biphenylarene are commercially available, the synthesis is simple and convenient, the yield is high, and the modification is convenient, so that the compounds and the derivatives have broad application prospects in gas adsorption and separation, performance improvement of light-emitting materials, and adsorption of water-soluble toxic substances.

Arizidinosilicones of the general formula (1), wherein R1 represents H, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkinyl, C7-C15 alkaryl, C7-C15 aralkyl, C3-C12 cycloalkyl and these groups can be substituted with Cl or F partially, completely or in a mixed manner and / or may contain 0 to 5 heteroatoms selected from O, N, S, R2 represents a group of the selection of R1 and / or R4, and R3 represents SiRl3 or SiR12R4, and wherein R4 represents formula (2), and A represents an (n+1) radical saturated, unsaturated or aromatic, linear, branched or cyclic hydrocarbon group that may contain 0 to 5 heteroatoms selected from O, N, S and that includes 1 to 18 carbon atoms, B is selected from O, S, NR1, D is selected from C(O)O, C(O)NR1, C(O), C(O)C(O), C(O)(CH2)m(C(O), C(S)NR1, CH2, E represents a diradical saturated or unsaturated, linear, branched or cyclic hydrocarbon group that may contain 0 to 5 heteroatoms selected from O, N, S and that includes 0 to 18 carbon atoms, a is 0 or 1, f is an integer from 2 to 1000, n, m is an integer from 1 to 10, and x, y, z each represents 0 or an integer, the sum of which should range between 1 and 10000, with the proviso that, if x is larger 0, y or z is smaller or equal x, preferably smaller or equal 0.05 times x, and especially preferred 0.02 times x. The invention also relates to the use of arizidinosilicones.

The invention discloses a two-dimensional Cd(II) porous complex of 1-(4-amino-benzyl)-1,2,4-triazole, and a synthesis method and an application of the complex. The triazole Cd(II) complex with a two-dimensional planar porous framework structure disclosed by the invention is mainly applied to the adsorption aspect of polycyclic aromatic hydrocarbon. An experiment result shows that the porous complex displays relatively good polycyclic aromatic hydrocarbon adsorption properties; and the triazole Cd(II) complex with the two-dimensional planar porous framework structure is mainly applied to the adsorption aspect of the polycyclic aromatic hydrocarbon, and particularly has a wide application prospect when applied to detection, analysis and research of environmental organic pollutants as a pre-enrichment material.

The present invention relates to heparin-binding calixarene compounds of general Formula (I) in which R, R1, L and n have the meanings indicated in the description and their use in the biomedical field.

The invention relates to polyoxometalates represented by the formula (An)m+ [Ru2L2(XW11O39)2WO2]m− or solvates thereof, wherein A is a cation, n is the number of the cations, m is the charge of the polyanion, L is a ligand bound to ruthenium and is independently selected from group consisting of water, unsubstituted or substituted arenes, unsubstituted or substituted heteroarenes, unsaturated hydrocarbons, ethers, unsubstituted or substituted allyl, unsubstituted or substituted alkanes, nitriles, carboxylates, peroxides, peracids, phosphines, phosphanes, CO, OH−, peroxo, carbonate, NO3−, NO2−, NO−, NH3, amines, F−, Cl−, Br−, I−, SCN−, NCS−, NCO− and mixtures thereof and X is a heteroatom selected from Si, Ge, B and mixtures thereof, a process for their preparation and their use for the catalytic oxidation of organic molecules.

The invention discloses 8-hydroxyquinoline functionalized column [5] arene P5Q. The functionalized column [5] arene P5Q can be constructed into a supramolecular organic framework P5QG having light blue aggregative state induced fluorescence together with bilateral six-carbon column [5] arene P5C6 through intermolecular self-assembling and the pi-pi stacking action of a gelator P5Q. The supramolecular organic framework P5QG and Fe<3+> can construct a supermolecular metal organic framework P5QG-Fe through the cation-pi action, and the process breaks the pi-pi stacking action of the gelator P5Q,which leads to fluorescence quenching of the supramolecular organic framework P5QG. Therefore, the supramolecular organic framework P5QG can be used for detecting the ultrasensitiveness of Fe<3+> viafluorescence, and the lowest detection line is 1.02 x 10<-11>M; and the Fe<3+> can be also removed from the aqueous solution (the removal rate is up to 99.96 percent).

The present invention relates to a process for the regioselective synthesis of compounds of the formula I,wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

Provided herein are palladium complexes comprising a ligand of Formula (A′) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.

The invention discloses calix (4) arene containing a coumarin structure, as well as a synthesis method and a use thereof and relates to the technical field of chemical synthesis processes. The synthesis method comprises the following steps: firstly mixing 2, 8, 14, 20-tetrapropyl-5, 11, 17, 23-tetraformyl-resorcinol calix (4), diethyl malonate, piperidine, glacial acetic acid and ethanol, then heating to 75-80 DEG C, performing heat preservation reaction till the end of reaction, then mixing a mixture after reaction with a saturated saline solution, filtering out a precipitate, taking the precipitate and recrystallizing with methanol to obtain the high-purity calix (4) arene containing the coumarin structure. The process disclosed by the invention has the advantages of mild reaction conditions, simplicity in operation, capability of constructing four coumarin rings on a mother nucleus of the calix (4) arene by one-step reaction in a one pot and relatively high yield. The calix (4) arene containing the coumarin structure, which is synthesized by the method provided by the invention, has good phase transfer catalytic action.

The invention discloses a method for preparing silver nano-particles with amino-pillar [5] arene as a stabilizer. The method comprises the steps that AgNo3 solution is added to an amino-pillar [5] arene solution and rapidly stirred, a NaBH4 solution is rapidly fed into the solution, stirring is performed for 5-10 minutes, and then the silver nano-particles protected by the amino-pillar [5] arene are obtained. The method for preparing the silver nano-particles with the amino-pillar [5] arene as the stabilizer overcomes the defects that by the adoption of traditional means, impurities are proneto being generated, and the structure of the silver nano-particles is prone to damage; and enough binding sites are provided and can achieve inclusion of small organic molecules.

The invention discloses a paddle wheel-shaped tin oxygen cluster complex composed of drum-shaped Sn6O6 and carboxyl calixarene and a preparation method thereof, and belongs to the chemical technical field. The complex has the following chemical formula: [(BuSn)(mu3-O)(L)]6.6(toluene); n-BuSn(O)OH and an HL ligand with a mixture of toluene and ethanol are subjected to heating reflux for 8 hours in a Dean-Stark apparatus, water generated in the reaction is removed by azeotropic distillation, and then the solution is subjected to reduced pressure distillation to obtain a white solid; a mixed solution of chloroform, dichloromethane and toluene is recrystallized at the room temperature to obtain a colorless crystal, and the yield is 53%. The invention discloses an anticancer activity research of organotin oxygen clusters based on calix[4]arene for the first time. The synthetic method has the characteristics of strong repeatability, high yield, stable product performance and the like. The complex shows relatively good fluorescence properties.

The invention discloses a refining method for synthesizing high-purity capsaicine. According to the method, calixarene capable of recognizing (trans)8-methyl-N-vanillyl-6-nonenamide molecules is synthesized through aldol condensation, Friedel-Crafts reaction, etherification and sulfonation; the calixarene and the (trans)8-methyl-N-vanillyl-6-nonenamide in synthetic capsaicine form (trans)8-methyl-N-vanillyl-6-nonenamide-calixarene host-guest recognition supramolecule through supramolecular interaction; and the precipitate is separated to obtain an n-nonanoic acid vanillyl amide solution, and after evaporation, desolvation and crystallization, the n-nonanoic acid vanillyl amide refined product with a content of higher than 99.8% is obtained. According to the invention, the purification method is environmentally-friendly, and calixarene has good cycle repeatability and high atom economy.

The invention discloses an aromatic hydrocarbon ruthenium complex, which adopts R 1 R 2 R 3 PIP is the main ligand, the R 1 , R 2 , R 3 independently selected from ‑Cl, ‑F, ‑Br, ‑I, ‑CF 3 ,‑NO 2 ,‑OCH 3 ,‑OH,‑COOH,‑CH 3 ,‑N(CH 3 ) 2 ,‑C 2 h 2 ,‑SO 2 CH 3 , an alkyl group with 1 to 6 carbon atoms or a substituted alkyl group with 1 to 6 carbon atoms, pyridyl or substituted pyridyl, furyl or substituted furyl, pyrrolyl or substituted pyrrolyl, thiazole or substituted thiazolyl; Wherein, the substituents of the phenyl, pyridyl, furyl, and thiazole are all independently selected from hydroxyl, nitro, halogen, amino, carboxyl, cyano, mercapto, cycloalkyl with 3 to 8 carbon atoms, SO 3 H, an alkyl group with 1 to 6 carbon atoms, an alkenyl group with 2 to 6 carbon atoms, an alkynyl group with 2 to 6 carbon atoms, a hydroxyl group (C 1 -C 6 ) Alkyl, amino (C 1 -C 6 ) Alkyl, CO 2 R', CONR'R', COR', SO 2 R'R', (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) alkylthio, -N=NR', NR'R' or trifluoro(C 1 -C 6 ) Any of the alkyl groups.

The invention discloses a phenothiazine-containing pillararene fluorescent adsorption material and a preparation method thereof. The structural general formula of the phenothiazine-containing pillararene fluorescent adsorption material is shown in the specification. The phenothiazine-containing pillararene fluorescent adsorption material disclosed by the invention is reasonable in molecular design, a synthesized target object is novel, and organic matter with similar structures can be specifically detected, adsorbed and separated; and the process can be monitored through the change of material fluorescence. The molecules are good in solubility, simple to synthesize and purify and variable in molecular structure, the synthesis method has universality, and functional compounds with different structures and properties can be conveniently designed according to needs.

A calixarene compound represented by structural formula (1). In the formula, R1 and R2 independently represent a structural part (A) having a functional group (I), a structural part (B) having a functional group (II) having a carbon-carbon unsaturated bond (excluding a maleate group), a structural part (C) having both of the functional groups (I) and (II), a monovalent organic group (D) having 1-20 carbon atoms other than the structural parts (A), (B) and (C), or a hydrogen atom (E), provided that at least one of a plurality of R2s represents the structural part (A), the structural part (B), the structural part (C) or the organic group (D). When the functional group (I) is a cyano group, an acetylacetonate group, an oxalate group or a malonate group, at least one of the plurality of R1s and R2s represents the structural part (C), or at least one of the plurality of R1s and R2s represents the structural part (A) and at least one of the same represents the structural part (B). When the functional group (I) is a maleate group, at least one of the plurality of R1s and R2s represents the structural part (A) or the structural part (C).

The invention discloses calix (4) arene containing a coumarin structure, as well as a synthesis method and a use thereof and relates to the technical field of chemical synthesis processes. The synthesis method comprises the following steps: firstly mixing 2, 8, 14, 20-tetrapropyl-5, 11, 17, 23-tetraformyl-resorcinol calix (4), diethyl malonate, piperidine, glacial acetic acid and ethanol, then heating to 75-80 DEG C, performing heat preservation reaction till the end of reaction, then mixing a mixture after reaction with a saturated saline solution, filtering out a precipitate, taking the precipitate and recrystallizing with methanol to obtain the high-purity calix (4) arene containing the coumarin structure. The process disclosed by the invention has the advantages of mild reaction conditions, simplicity in operation, capability of constructing four coumarin rings on a mother nucleus of the calix (4) arene by one-step reaction in a one pot and relatively high yield. The calix (4) arene containing the coumarin structure, which is synthesized by the method provided by the invention, has good phase transfer catalytic action.

The invention relates to a hierarchical pore molecular sieve, and a preparation method and application thereof. The hierarchical pore molecular sieve is prepared from a silicon source, an aluminum source, a hard template, an organic alkali and water, the hard template comprises a cyclic organic compound, and the cyclic organic compound is selected from beta-cyclodextrin, crown ether, polyether andcalixarene cyclic organic compounds. The preparation method comprises the following steps: dissolving the hard template in water, adding the aluminum source and the silicon source, uniformly mixing,adding the organic alkali, curing to form gel, crystallizing and roasting the gel, and removing the template to obtain the hierarchical pore molecular sieve. The hierarchical pore molecular sieve provided by the invention can effectively improve the adsorption capacity of volatile organic compounds and enhance the mass transfer efficiency, and the preparation method is simple in process and easy for large-scale preparation.

Disclosed herein are ruthenium arene Schiff-base complex and uses thereof. The ruthenium arene Schiff-base complex disclosed herein has the structure of formula (I),wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are independently H, alkyl, alkoxyl, or halo; R13, R14, R15, R16, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2; or R13 and R14 are taken together to form a benzene ring, while R15, R16, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2; or R14 and R15 are taken together to form a benzene ring, while R13, R16, and R17 are independently H, alkyl, alkoxyl, hydroxy, halo, —C(═NH)NH2, —SO3H, —SO2NH2, —NR′R″, or —CONH2; R′ and R″ are independently H or alkyl; the alkyl is optionally substituted with one or more halo or hydroxy, or hydroxy; and Y is a counter anion. Also disclosed herein are methods of treating malignant neoplasm in a subject. The method includes administering an effective amount of the ruthenium arene Schiff-base complex of formula (I) to the subject to alleviate symptoms associated with the malignant neoplasm. Exemplary malignant neoplasm includes, but is not limited to triple-negative breast cancer.

The invention provides a passivator and a preparation method thereof, and relates to the technical field of chemical material preparation. The preparation method of the passivator comprises the following steps: S1, mixing an antimony salt, a tin salt and an aromatic solvent to form a first solution; S2, adding a cross-linking agent into the first solution, and reacting to obtain a second solution;S3, sequentially adding organic amine and deionized water into the second solution, and reacting to obtain a mixture; S4, heating and evaporating the mixture to obtain a solid intermediate; and S5, calcining the solid intermediate to obtain the passivator. According to the preparation method of the passivator, the surface of the prepared SbSn / C passivator has certain oleophylic performance, the adsorption acting force on porphyrin molecules is enhanced through Van der Waals' force action and pi-pi action with macromolecules such as porphyrin nickel and porphyrin vanadium, and impurities suchas Ni and V in crude oil are effectively removed.

The present invention relates to a Halomonas bacterial strain Halomonas sp.BN3-1, characterized in that: its nucleotide sequence is as shown in SEQ ID NO.1, compared with the prior art, the present invention has the following advantages: The Halomonas bacterium of the present invention degrades polycyclic aromatic hydrocarbons faster, and the Halomonas bacterium is cultivated in 100ml culture medium (the solubility of phenanthrene is 100mg / L) for one week, bacterial strains BN1‑1, BF1 The degradation rates of ‑1 and BN3‑1 to phenanthrene were 30%, 33%, and 74%, respectively, and the strain BN3‑1 had a higher degradation rate.

The invention discloses a preparation method of trans tetrasubstituted olefin derivatives, comprising the following steps: (1) adding alkali, alkyne, palladium catalyst, ligand, halogenated aromatic hydrocarbon, precursor compound and organic solvent into a reaction vessel , after filling repeatedly with nitrogen, react at 80-140°C for 12-36h; (2) dilute the material obtained in step (1) with ethyl acetate, and then wash with water to separate the organic phase; (3) the step ( 2) The obtained organic phase is dried, filtered, concentrated and subjected to column chromatography or thin layer chromatography to obtain the trans tetrasubstituted olefin derivative. The present invention can simultaneously obtain trans tetrasubstituted olefins substituted by tetraaryls and trans tetrasubstituted alkenes substituted by triaryls and trimethylsilicon, and has good regioselectivity, and can synthesize trans tetrasubstituted alkenes which are difficult to obtain by other methods compound.

The invention provides an adsorbent, a preparation method and application thereof. The adsorbent is prepared from functionalized magnetic Fe3O4 nanoparticles as a carrier, sulfonated calix[6]arene obtained by pre-modifying calix[6]arene and trimesoyl chloride in an N, N-dimethylformamide solvent through a nucleophilic substitution reaction, wherein the adsorbent not only has an inherent large cavity structure of the calix[6]arene, but also has a cross-linked net structure. The adsorbent shows inherent superparamagnetism, large specific surface area, excellent stability and abundant binding sites, and shows excellent performance in separation, enrichment and energy gathering of target compounds.