62 results about "Araneosene" patented technology

The invention is applicable to the technical field of metal organic framework materials, and provides a pillararene-based metal organic framework material and a preparation method thereof.The pillararene-based metal organic framework material takes a compound PY2-P5 as a ligand, and the material is one of PMOF1, PMOF2 and PMOF3; the PMOF1 is of a Cu4I4 cubic tetramer structure; the PMOF2 is of a Cu4I4 ladder tetramer structure, and the Cu4I4 ladder tetramer structure is a And the PMOF3 has a CuI one-dimensional chain structure. By introducing the pillararene ligand and regulating and controlling the coordination mode of the pillararene ligand and cuprous iodide, the metal organic framework material with stable structure and functional characteristics is constructed, the metal organic framework material has the dual advantages of host recognition site and fluorescence signal response, and can selectively distinguish 1-bromoalkane and 2-bromoalkane; a remarkable fluorescent blue shift signal is shown in the adsorption process, so that the visualization of molecular recognition and sensing is realized; the excellent molecular recognition capability of pillararene is maintained, the stability and reusability of the material are improved through framing, and a new way is provided for selective detection and separation of volatile organic compounds.

The invention belongs to the field of organic photoelectric materials, and relates to a cyanoindanone-modified boron-aza polycyclic aromatic hydrocarbon, and a preparation method and application thereof, and the cyanoindanone-modified boron-aza polycyclic aromatic hydrocarbon has a structure as shown in a general formula I and a general formula II. The cyanoindanone-modified boron-nitrogen heterocyclic polycyclic aromatic hydrocarbon provided by the invention shows the properties of wide spectrum and strong absorption, and meanwhile, the boron-nitrogen compound has a red-shifted absorption edge which can reach 815 nm at most.

The invention discloses a method for preparing < 18 > F-m-fluorobenzylguanidine, and solves the technical problems of complex reaction steps, low radiochemical yield and low specific activity in a method for synthesizing < 18 > F-mFBG. The invention comprises a phenolic ether precursor compound of a core skeleton corresponding to 18F-mFBG, a synthesis method of the phenolic ether precursor compound, and a method for realizing F-18 labeling and preparation of mFBG by using the precursor compound. Specifically, 18F-mFBG labeling and preparation are realized by constructing a key phenolic ether precursor compound and performing simple and efficient photocatalytic deoxidation fluorination reaction on aromatic hydrocarbon. The method has the advantages of few steps, high yield, simplicity and convenience in operation, good repeatability and good automatic production potential. The radioactive tracer 18F-mFBG synthesized by the method is high in specific activity, chemical purity and radioactive purity, and has important value for clinical popularization of targeted NET molecular function PET imaging.

Provided are: a compound which is a curable resin and from which a cured product exhibiting recoverability and re-moldability can be easily obtained; a curable resin composition obtained using the same; and a cured product thereof. An amino group-containing compound according to the present invention is represented by general formula (1) and has a molecular weight of less than 1,000. [chemical formula 1] [In general formula (1), m is an integer of 1-10. Z1s are each independently a hydrogen atom, an amino group, a halogen atom, an alkoxy group, an aralkyloxy group, an aryloxy group, a nitro group, an amide group, an alkyloxycarbonyl group, an aryloxycarbonyl group, a cyano group, an alkyl group, a cycloalkyl group, an aralkyl group, or an aryl group, and at least one among Z1s is an amino group or a group having an amino group as a substituent. Z3 is one among structures represented by formula (2) in the text.

The invention discloses an N-heterocyclic carbene palladium complex as well as a preparation method and application thereof. The structure of the N-heterocyclic carbene palladium complex is as shown in a formula (I): # imgabs0 # formula (I), the N-heterocyclic carbene palladium complex can be used for catalyzing an arylation reaction of aryl halide and has the advantage of high yield, and an arylation homopolymer of aryl halide prepared through catalysis has the characteristics of narrow distribution and low molecular weight.

Metal complex having a general formula Ir(L a ) m (L b ) n exhibits, whereby it is L a and L b about the first ligand and the second ligand, each coordinated to the metal Ir; and L a and L b optionally, they can be connected in such a way that they form a multidentate ligand; m is equal to 1, 2 or 3, n is equal to 0, 1 or 2, and m+n corresponds to the oxidation state of the metal Ir; where, if m is greater than or equal to 2, the multiple L a are the same or different; if n equals 2, the two L b are the same or different; where L a a structure represented by formula 1a: where Z is selected from the group consisting of O, S, Se; X3 to X7 the same or different from CR in every occurrence x or N can be selected; Y1 to Y4 are the same or different in each occurrence from CR y or N can be selected; X7 is a CR x it is about and the R x it is cyano; At least one of Y1 to Y4 is a CR y deals and the R y selected from the group consisting of: halogen, a substituted or unsubstituted alkyl with 1 to 12 carbon atoms, a substituted or unsubstituted cycloalkyl with 3 to 10 ring carbon atoms, a substituted or unsubstituted alkenyl with 2 to 10 carbon atoms, a substituted or unsubstituted aryl with 6 to 20 carbon atoms, a substituted or unsubstituted heteroaryl with 3 to 20 carbon atoms and combinations of these; R x and R yThe following are selected from the group consisting of: hydrogen, deuterium, halogen, a substituted or unsubstituted alkyl with 1 to 12 carbon atoms, a substituted or unsubstituted cycloalkyl with 3 to 10 ring carbon atoms, a substituted or unsubstituted alkenyl with 2 to 10 carbon atoms, a substituted or unsubstituted aryl with 6 to 20 carbon atoms, a substituted or unsubstituted heteroaryl with 3 to 20 carbon atoms and combinations thereof; Ar is selected from the group consisting of: a substituted or unsubstituted aryl with 6 to 20 carbon atoms, a substituted or unsubstituted heteroaryl with 3 to 20 carbon atoms, and combinations thereof; and neighboring substituents R x , R yand Ar can optionally be connected in such a way that they form a ring; it is L b In each instance, whether the same or different, it is an arbitrary one selected from the group consisting of the following structures: where R a and R b Whether each occurrence is the same or different, they represent a monosubstitution, a multiple substitution or a non-substitution; R a and R bThe following are selected from the group consisting of: hydrogen, deuterium, halogen, a substituted or unsubstituted alkyl with 1 to 20 carbon atoms, a substituted or unsubstituted cycloalkyl with 3 to 20 ring carbon atoms, a substituted or unsubstituted heteroalkyl with 1 to 20 carbon atoms, a substituted or unsubstituted heterocyclic group with 3 to 20 ring atoms, a substituted or unsubstituted arylalkyl with 7 to 30 carbon atoms, a substituted or unsubstituted alkoxy with 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy with 6 to 30 carbon atoms, a substituted or unsubstituted alkenyl with 2 to 20 carbon atoms, a substituted or unsubstituted aryl with 6 to 30 carbon atoms, a substituted or unsubstituted heteroaryl with 3 to 30 carbon atoms,a substituted or unsubstituted alkylsilyl with 3 to 20 carbon atoms, a substituted or unsubstituted arylsilyl with 6 to 20 carbon atoms, a substituted or unsubstituted amino with 0 to 20 carbon atoms, an acyl group, a carbonyl group, a carboxylic acid group, an ester group, a cyano group, an isocyano group, a hydroxy group, a sulfanyl group, a sulfinyl group, a sulfonyl group, a phosphino group and combinations thereof; and , in structures of L b neighboring substituents R a and R b They can optionally be connected in such a way that they form a ring.

The present invention relates to the technical field of durene preparation, and discloses a method for simultaneously separating durene, prehnitene and pseudodurene from C10 aromatics. In this method, the C10 aromatics are distilled to remove heavy components, and after obtaining a durene mixture, atmospheric distillation is carried out to obtain a first durene-enriched liquid, a first prehnitene-enriched liquid and a first pseudodurene-enriched liquid; then the three durene-enriched liquids are respectively subjected to vacuum distillation to obtain a second durene-enriched liquid, a second prehnitene-enriched liquid and a second pseudodurene-enriched liquid; the second durene-enriched liquid is subjected to first cooling crystallization to obtain durene; the second pseudodurene-enriched liquid is subjected to second cooling crystallization to obtain pseudodurene; the second prehnitene-enriched liquid is contacted with a metal-organic framework material and then separated to obtain prehnitene. This method can not only separate the three durenes from C10 aromatics, but also take into account the purity and yield of the three durenes.

The invention designs and synthesizes a compound constructed on the basis of 1, 10-phenanthroline and 4-(9-carbazolyl) phenylboronic acid, and the compound is obtained through a Suzuki-Miyaura reaction in one step. The method has the advantages of mild reaction conditions, simple reaction steps, high yield of finished products and the like. Due to the existence of C-Hpi interaction among molecules, the compound forms a three-dimensional network structure with a cavity in a crystalline state, so that the small-molecule compound has excellent properties which are the same as those of a traditional macrocyclic aromatic hydrocarbon main body; and under the condition of no induction, self-assembly can occur to form a non-covalent bond molecular pipeline for adsorbing and packaging benzene series pollutants. In the adsorption process, the energy consumption is low, the adsorption time is short, the equipment requirement is low, the selected crystalline material is easy to synthesize, the yield is high, the stability is strong, the adsorption quantity of benzene series pollutants is high, and the adsorption effect is good.

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The invention relates to a compound of formula (I) and to the process for the preparation thereof (I) in which: - T is selected from the group consisting of CN+-O-, CH=NOH and CHO; - A represents a C6-C14 arenediyl ring, optionally substituted by one or more hydrocarbon chains, identical or different, aliphatic, preferably saturated, linear or branched; - E represents a C2-C12 divalent hydrocarbon group optionally comprising one or more heteroatoms; and - Ra, Rb, Rc, identical or different, represent a C1-C6 alkyl.

A catalyst for converting C9+ aromatics to lighter aromatics comprises metal functional groups derived from a metal such as platinum confined in cages and / or channels of a microporous material such as chabazite, wherein the cages and / or channels of the microporous material comprise metal functional groups defined by 8 or fewer tetrahedral atoms and acidic functional groups derived from an additional zeolite having cages and / or channels defined by 10 or more tetrahedral atoms, wherein the microporous material providing the metal functional groups and the additional zeolite providing the acidic functional groups are bound together by a binder.

To provide guest phosphorescent materials for use in organic electroluminescent components useful in enhancing the photochemical stability, preventing undesirable host and guest interactions, extending the lifetime of the components, achieving high color purity, and the like.SOLUTION: The disclosure provides: metal platinum (II) complexes having a [2.2]paracyclophane-based structure shown in Formula (I); and electronic components and apparatuses that employ the complexes.SELECTED DRAWING: Figure 1

The invention discloses a functionalized planar chiral pillararene and a preparation method and application thereof, the functionalized planar chiral pillararene comprises a compound I, a compound II, a compound III, a compound IV, a compound V and a compound VI, and also comprises stereoisomers of the compound I, the compound II, the compound III, the compound IV, the compound V or the compound VI; the preparation method comprises the following steps: adding an organic boron compound, a palladium catalyst, a chiral ligand, alkali and column [n] arene into a solvent according to a certain proportion, carrying out an anaerobic heating reaction, and after the reaction is finished, carrying out post-treatment to obtain the chiral column arene derivative. When n is equal to 5, the column [n] arene is a compound VII, and when n is equal to 6, the column [n] arene is a compound VIII. According to the functionalized surface chiral pillararene and the preparation method and application thereof, the chiral pillararene derivative with high yield, high ee value, high optical activity, excellent fluorescence emission performance and large electron-rich cavity is obtained, and the chiral pillararene derivative can be used as a chiral luminescent material, a chiral catalyst carrier and the like.

The invention discloses a calixarene derivative and a preparation method and application thereof, the structure of the calixarene derivative is as shown in formula I: R1 is CO2-NH4 < + >; r2 is any one of straight-chain alkyl, branched-chain alkyl, straight-chain alkyl containing double bonds and branched-chain alkyl containing double bonds. According to the invention, iodobalix [4] arene and an alkynyl-containing phenyl compound are connected through a Sonogashira coupling reaction to construct an extended aromatic macrocyclic skeleton, and then an ionic water-soluble structure is obtained through upper edge ester group hydrolysis. The calixarene derivative has the following innovative advantages that the depth and the volume of a cavity are remarkably increased, and large-volume guest molecules can be efficiently included; the extended cavity realizes effective inclusion of guest molecules through hydrophobic interaction and Van der Waals force; an upper edge carboxylate radical ion group specifically recognizes a cationic object through electrostatic interaction, so that the multi-site recognition function of enzyme is simulated; the water solubility is enhanced, and the method is suitable for the biological medicine fields of drug delivery, ion sensing and the like.

The invention discloses a torsion regulation-based ultrafast broadband optical limiting material design method, a material and application, and relates to the field of optical limiting materials.The torsion regulation-based ultrafast broadband optical limiting material design method comprises the steps that structure optimization is conducted on double-branched-chain polycyclic aromatic hydrocarbon molecules through a computer based on the density functional theory, then the vibration frequency of each molecule is calculated, and the vibration frequency of each molecule is calculated; ensuring that the molecular configuration of the double-branched-chain type polycyclic aromatic hydrocarbon molecule after structure optimization is at the lowest point of a potential energy surface, and obtaining the double-branched-chain type molecule with a polycyclic conjugated structure, wherein the dihedral angle between a core group and a side chain group is 90 degrees; and adjusting a pi bridge between the core group with the polycyclic conjugated structure and the side chain group, so that a dihedral angle between the core group and the side chain group is gradually changed from 90 degrees to 0 degree, thereby obtaining the ultrafast broadband optical limiting material. The research of the invention clearly clarifies the anti-saturated absorption enhancement mechanism of the two-branch anthracene derivatives, and lays a foundation for the development of novel organic optical limiting materials.

Metal complex with general formula Ir(L a ) m (L6) n , where L a and L b a first ligand and a second ligand are coordinated with the metal Ir; m is 1 or 2, n is 1 or 2, and m+n corresponds to the oxidation state of Ir; if m is 2, two L a are the same or different; if n is 2, two L b are the same or different; L a , whether the same or different in each occurrence, exhibits a structure represented by formula 1A, and L b , which, whether the same or different in each occurrence, exhibits a structure represented by the formula 1Ba: where Z is selected from the group consisting of O, S and Se; X3 to X8, the same or different in each occurrence, selected from CR x ; Y1 to Y4, the same or different in each occurrence, are selected from CR y or N; U1 to U4, the same or different for each occurrence, are selected from CR u or N; W1 to W4, the same or different for each occurrence, are selected from CR w or N; R x , R y , R u and R w, the same or different in each occurrence, are selected from the group consisting of: hydrogen, deuterium, substituted or unsubstituted alkyl with 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl with 3 to 20 ring carbon atoms, substituted or unsubstituted arylalkyl with 7 to 30 carbon atoms, substituted or unsubstituted alkenyl with 2 to 20 carbon atoms, substituted or unsubstituted aryl with 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl with 3 to 30 carbon atoms, substituted or unsubstituted alkylsilyl with 3 to 20 carbon atoms, substituted or unsubstituted arylsilyl with 6 to 20 carbon atoms, a cyano group, an isocyano group and combinations thereof; one of U1 to U4 from CR u are selected and R usubstituted or unsubstituted alkyl with 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl with 3 to 20 ring carbon atoms or a combination thereof, and the total number of carbon atoms in R u at least 4; at least one of R x Cyano is; and neighboring substituents R x , R y , R u , R w They may be connected to form a ring.

This invention provides a column[5]arene-based bicyclic molecule that can detect dichromate ions with high selectivity and high sensitivity through enrichment effect. The column[5]arene-based bicyclic chemical sensor BPN1 was obtained by reacting bis-N-(2-aminoethyl)-2-(hexamyl)acetamide-functionalized column[5]arene with 1,4,5,8-naphthalenetetracarboxylic anhydride in DMF solution. The DMSO-H2O solution of the bicyclic chemical sensor BPN1 showed fluorescence at 455 nm, and the addition of Cr2O7... 2‑ The addition of other ions to the aqueous solution of BPN1 can induce fluorescence quenching, while the fluorescence of BPN1 does not change significantly upon the addition of other ions. Therefore, the dual macrocyclic chemical sensor BPN1 enables the detection of Cr2O7. 2‑ Single-selective recognition. Fluorescent titration experiments showed that this sensor molecularly recognizes Cr2O7. 2‑ It has high sensitivity.

The present invention relates to the technical field of biomedicine, and in particular to a preparation method for 18F-DOPA and an F-18-labeled precursor thereof. The structural formula of an F-18-labeled phenolic precursor compound is as shown in formula I, wherein R1 and R2 are hydroxyl protecting groups; R3 is a leaving group; R4 and R5 are each independently hydrogen or an amino protecting group; and R6 is a carboxyl protecting group. The present invention provides a simple and efficient preparation method for 18F-DOPA, specifically by constructing a key phenolic precursor compound and by means of a simple and efficient photocatalytic aromatic hydrocarbon deoxyfluorination reaction to implement the preparation of 18F-DOPA. The method has fewer steps, high yield, simple and convenient operation, good reproducibility, and good automated production potential. The radiotracer 18F-DOPA synthesized by means of the method has high specific activity and high chemical purity and radiochemical purity, and has significant value for the clinical promotion of 18F-DOPA.

A process for fluorination of a fluoride acceptor species comprising contacting an organofluorine species with a base to provide a fluoride donor species and contacting the fluoride donor species with the fluoride acceptor species to form a fluorinated species. The organofluorine species can be a species of formula (1): R1R2HC-CFR3R4; (1a): R1R2C=CFR3, or a fluoroarene; wherein R1, R2, R3 and R4 are each independently selected from H, halogen, and substituted or unsubstituted alkyl, alkoxide, aminoalkyl, or aryl.

The application relates to the technical field of organic functional molecule synthesis, and particularly discloses a pyran unit embedded bisanthene compound and a synthesis method. The method takes compound 1 as raw material, and under the condition of a sodium borohydride and boron trifluoride ether collaborative reduction system and room temperature, a single selective edge pyran ring is constructed through carbonyl activation-hydrogen transfer-intramolecular cyclization, and the yield is 60%, and the atomic economy is high. The obtained compound A has a maximum absorption characteristic peak at 726 nm in dichloromethane, and a maximum emission characteristic peak at 960 nm; after being made into nanoparticles, the photo-thermal conversion efficiency reaches 53% under the irradiation of an 808 nm laser (0.5 W cm-2), and the photo-thermal stability is significantly improved. The synthesis route has the advantages of mild conditions, simple operation and high atomic economy, and provides a universal strategy for the functionalization of oxygen-doped fused ring arenes and the preparation of high-efficiency photo-thermal materials.

Stilbene derivatives, a preparation method therefor and the use thereof are provided. Compounds of formula (I-1), and stereoisomers, pharmaceutically acceptable salts or prodrugs thereof can serve as an aryl hydrocarbon receptor (AHR) regulator. Compared with marketed drug Benvitimod, the compounds of formula I-1 have greatly improved molecular structure stability under illumination, thus overcoming photoinstability of Benvitimod, and solving the problem of Benvitimod being liable to degrade under illumination. In addition, the compounds of formula I-1 have remarkably improved activity on AHR protein. And finally, the preparation method for the compounds of formula I-1 is simple, and can achieve gram-level or kilogram-level preparation.

The present invention discloses a method for synthesizing a catalytic material for highly efficient catalytic reduction of nitroarenes and its application. By synthesizing two-dimensional metal-organic framework Co MOF, controlling the concentration of Na2PdCl4, and in-situ synthesizing ultra-small Pd nanoparticles at the edges of its two-dimensional structure, a highly efficient catalytic material Co MOF@Pd for catalytic reduction of nitroarenes is finally obtained. Under the condition of the same Pd content, using NaBH4 as the hydrogen source, the conversion rate of Co MOF@Pd for highly efficient catalytic reduction of nitroarenes exceeds 99%, and the TOF value reaches 9800 h ‑1 , which is 206 times that of commercial PdC with a Pd content of 10 wt%. In addition, this catalyst has good cycle stability. After 5 cycles, the catalytic activity remains 86%, while the catalytic activity of PdC is only 45%. The synthesis method of the present invention is simple, low-cost, has high catalytic activity, and the catalyst is easy to separate, recover and recycle.

The invention relates to a compound of the formula (i); Py-X (i) wherein: Py is a polycyclic aromatic hydrocarbon moiety, X is a therapeutic moiety or a diagnostic moiety or a bioactive moiety, and wherein the therapeutic moiety or the diagnostic moiety or a bioactive moiety is not an osmium complex.