33 results about "Histidine kinase" patented technology

Compounds that competitively inhibit binding of CSP to S. mutans histidine kinase are provided. The compounds are preferably a peptide or an antibody, and are preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2]. Methods of making these compounds and their use for inhibiting the growth of S. mutans, for inhibiting dental caries, and for improving dental health are also disclosed.

Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.

The invention relates to a drug screening model taking histidine kinase AgrC as a target spot, belonging to the field of biological medicines. A construction method of the drug screening model comprises the following steps: (1) extracting and purifying AgrC protein; (2) determining the concentration of AgrC protein; (3) preparing lipidosome by taking DOPC, DPPA and CHOL as raw materials; (4) inserting the extracted and purified AgrC protein into the lipidosome by adopting a surfactant-mediating method, thus forming protein lipidosome; and (5) constructing the drug screening model taking the histidine kinase AgrC as the target spot. The constructed drug screening model is suitable for screening drug monomeric compounds having a strong inhibiting effect for histidine kinase AgrC, and the screened compounds are definite in acting sites; the drug screening model has the advantages of high flux, strong specificity and operation convenience and rapidness when used for screening the drug monomeric compounds.