20 results about "Infiltration skin" patented technology

A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer / hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water. A method of application of a transdermal delivery composition to skin tissue includes applying the transdermal delivery composition to skin tissue and spreading the composition to form a film on the skin tissue. A method for formulating a transdermal delivery composition based on a desired penetration weight ratio of CBD to THC through skin tissue includes selecting a formulation weight ratio of CBD to THC for formulating the composition, wherein the weight ratio is determined by multiplying the desired penetration weight ratio of CBD to THC by a CBD / THC delivery factor, wherein the CBD / THC delivery factor.

The present invention provides a transdermal composition that allows an active substance to effectively penetrate the skin and exert a predetermined effect, and uses thereof, wherein the transdermal composition contains an active substance that can exert a predetermined effect, and the transdermal composition is in the form of an emulsion, in which, calculated in mass percentages based on the total weight of the transdermal composition, the oil phase accounts for 15% to 50%, or 30% to 45%, or 35% to 40%, the emulsifier accounts for 35% to 65%, or 40% to 50%, and the aqueous phase accounts for 10% to 35%, or 10% to 25%.

The invention discloses a safe and long-acting mosquito-repelling compound, a mosquito-repelling nano-carrier and a mosquito repellent. The mosquito-repelling compound is prepared by chemical crosslinking or non-covalent binding of mosquito-repelling active substances and biological macromolecules, high-molecular polymers or skin-friendly micromolecules. The mosquito repelling compound effectively prolongs the action time, and experiments show that the super-high mosquito repelling rate larger than or equal to 99.4% is always kept within the period as long as 24 h. In addition, compared with a free mosquito-repelling active substance, the mosquito-repelling compound is large in molecular weight and only adheres to the skin cuticle but does not permeate into the skin barrier, so that the mosquito-repelling compound has lower biotoxicity and skin irritation.

The application discloses a plant extract composition with skin care effect and application thereof, and relates to the technical field of skin care daily chemicals. The plant extract composition with skin care effect provided by the application realizes skin multidimensional care through synergistic compatibility of lipid-soluble components and various aqueous plant extracts. The oily components penetrate the skin to nourish and repair, and the aqueous extracts are used to adjust the skin microenvironment. The two components are compounded to jointly construct an oil control and bacterium inhibition formula; the American ginseng extract enhances the hair follicle activity, and the red clover extract balances the hormone metabolism. The plant extract composition of the application realizes synergistic effects of whitening, antioxidation, barrier repair and microecological regulation while maintaining mildness through the compound compatibility of various substances. Especially, the water-oil phase separation problem of the composition is solved through the nanoemulsion technology, and the bioavailability of active ingredients is improved.

The invention relates to a cosmetic composition which is essentially plant-based, which is virtually water-free and which, when used topically on the skin, preferably dry skin, generates a pleasant warmth in contact with water, so that the skin pores are dilated and plant ingredients can advantageously penetrate the skin. The invention further relates to the preparation of such a cosmetic composition and its use, in particular as a cleansing product or rinse-off product.

The utility model discloses a portable travel is with many gears adjusting shower, related to shower technical field, including handle, handle top includes shower nozzle and depth cleaner, and handle outer wall top additionally has a plurality of clamping sliding blocks, and the inner wall bottom of shower nozzle and depth cleaner all are equipped with a plurality of L type clamping components, and the top end fixed connection of handle inner chamber has flow regulating valve, and flow regulating valve outer wall one side is installed valve stem, the utility model discloses can through rotating shower nozzle, separates shower nozzle with handle, replaces depth cleaner, because depth cleaner is cylindrical modeling, makes it better to explore the private place of user, under the action of the release medicine efficacy of impeller assembly and medicine basket inner medicine bag, and water flow is pulsed from the multiple water outlet holes at the front end of depth cleaner and sprays, effective penetration skin wrinkle and secret gap, and through the convex point of depth cleaner outer wall additional rubbing with skin, realize to skin wrinkle and secret gap's thorough cleaning.

The invention relates to the technical field of skin care and repair, in particular to a skin barrier repair composition containing nano repair, which comprises a nano-scale active component, a biocompatible high polymer material, a plant extract and a humectant. By optimizing the formula design and the preparation process, the composition can deeply permeate into the skin, promote barrier repair, reduce water loss, scavenge free radicals and improve the problems of dryness and sensitivity. The invention further provides a preparation method, a performance testing method and application of the polymer, and the polymer can be widely applied to the fields of cosmetics, biological medicine and medical instruments. Cost control and storage and transportation optimization measures are adopted, the production cost is remarkably reduced, and the stability is improved. The defects of component design, action depth and cost control in the prior art are overcome, and the method has remarkable technical advantages and market prospects.

The present invention aims to provide an analytical method that allows for a three-dimensional evaluation of the distribution of components that have penetrated the skin in a state closer to that of a living organism. [Solution] A method for analyzing components that have penetrated skin tissue, comprising the steps of: 1) bringing a drug into contact with skin tissue; 2) freezing the skin tissue from step 1; 3) scraping the frozen skin surface from step 2 using a gas cluster ion beam; and 4) performing TOF-SIMS measurement on the frozen skin surface scraped in step 3 to detect secondary ions of components derived from the drug and secondary ions of components derived from the skin. By performing TOF-SIMS measurement while scraping the frozen skin with a gas cluster ion beam, the ion distribution derived from the penetrated components can be analyzed, allowing for analysis of the skin permeability of components applied to the skin in a state closer to that of a living organism.

The present invention involves the formation of host-guest complexes between C-methylresorcin[4]arene and Oxybenzone (OXB). NMR spectroscopy confirmed the formation of a weak host-guest complex and molecular dynamics docking simulations indicated that this complex likely had a 1:1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C-methylresorcin[4]arene significantly reduced the amount of OXB that permeated skin. These results show the potential of supramolecular complexation for improving the stability and decreasing the skin permeability of OXB, thus limiting harmful side effects.

The invention provides a preparation method of a pain-relieving and itching-relieving traumatic injury spray, and belongs to the technical field of medicines.The method comprises the steps that orchid, spiny tree seeds and zanthoxylum bungeanum are selected according to the proportion of 1: 0.5: 0.5, dried at the temperature of 20-25 DEG C (preferably 22 DEG C) and the humidity of 30%-40% (preferably 35%), smashed to 80-120 meshes (preferably 100 meshes) and cooked for 4 hours under the pressure of 0.05-0.1 MPa (preferably 0.08 MPa), and then the mixture is filtered and dried to obtain the pain-relieving and itching-relieving traumatic injury spray. And cooling, stirring and mixing with 45% alcohol at a speed of 100-150 revolutions per minute (preferably 120 revolutions per minute), filtering by a filter screen of 150-200 meshes (preferably 180 meshes), and filling. According to the method, through scientific compatibility and precise process control, the problems that an existing spray is low in effective component extraction rate and poor in stability are solved, the prepared spray can rapidly permeate skin, the effects of relieving pain and itching and promoting injury repair are achieved, use is convenient, and quality is controllable.

The invention relates to an anti-aging repair composition containing a golden camellia extract and application. The liposome composition sequentially comprises a core layer, a shell layer and a chitosan coating from inside to outside, wherein the core layer comprises a camellia nitidissima extract and DNA sodium; the shell layer comprises lecithin, cholesterol, ceramide and an enzymolysis tea extract. Active substances are wrapped by a coating liposome wrapping technology, the active substances are helped to permeate the skin, the skin aging condition is comprehensively improved from multiple dimensions of promoting collagen synthesis, enhancing skin elasticity, resisting oxidation, repairing damaged skin barriers and the like, and the remarkable anti-aging and repairing effects are achieved.

The utility model discloses a traditional Chinese medicine external application device for adjuvant therapy of pancreatitis, which relates to the technical field of traditional Chinese medicine external application equipment and comprises a waistband wrapped on the waist of a patient with pancreatitis, and a heating massage component for applying a traditional Chinese medicine bag is arranged in the middle of the waistband. The heating massage assembly comprises an inner bag, the inner bag is sewn on the inner side of the middle of the waistband, a traditional Chinese medicine bag for treating pancreatitis is located in the inner bag, a heating cavity used for containing a heating bag is formed in the middle of the waistband, and the traditional Chinese medicine bag in the inner bag is heated through the heating bag in the heating cavity; an outer bag is sewn on the outer side of the middle of the waistband, a plurality of air bags a distributed at equal intervals are fixed to the inner wall of the outer bag, and the traditional Chinese medicine bag is extruded to be close to a patient by sequentially inflating and deflating the air bags a to achieve the massage effect. Two modes of heating and massaging are simultaneously applied, so that medicine is tightly attached to the abdomen of a patient, the medicine is promoted to better permeate into the skin, and the curative effect is further improved.

The present disclosure relates to a composition for promoting the activity of epidermal growth factor (EGF), comprising Compound K. Specifically, the composition for promoting the activity of EGF, according to the present disclosure, promotes the activity of EGF, which hardly permeates into the stratum corneum of the skin and has very low stability in cosmetic formulations, making it difficult to expect its effectiveness as a cosmetic ingredient, and thus when mixed with a low content of EGF, which alone does not exhibit an effect, excellent skin efficacy may be exhibited due to the epidermal cell proliferation activity of EGF.

The present application relates to a kind of microstructure supermolecular elastin, the microstructure supermolecular elastin includes liposome and supermolecular elastin and hydrolyzed elastin wrapped inside liposome;The membrane material of the liposome includes phospholipid and polyol.The present application creatively constructs an elastin liposome, supermolecular elastin and hydrolyzed elastin are co-encapsulated in the inside of liposome, can significantly improve the skin delivery depth of elastin, realize the efficient, safe transdermal delivery of macromolecular active protein;While supermolecular elastin and hydrolyzed elastin are mutually synergistic, can deeply penetrate skin, realize the effect of moisturizing and anti-wrinkle.

The application discloses a health preserving pot and relates to the technical field of physiotherapy appliances, which comprises a pot body, a fixing needle for fixing an incense stick arranged in the pot body, a conveying mechanism, a top cover detachably connected to the top of the pot body, a motor fixedly arranged in the top cover, a pushing assembly arranged in the pot body, and a reciprocating mechanism arranged between the pushing assembly and the motor. The inner piston and the outer piston are alternately moved up and down, and the one-way valve is used to continuously and directionally convey the medicinal smoke generated by the incense stick combustion to the bottom of the pot body and act on the human body surface. The design can make the medicinal smoke fully penetrate the skin and act on the acupoints, improve the utilization rate of the medicinal smoke, strengthen the warm and dispersing cold and qi-regulating and blood-activating effect of moxibustion, and further ensure the concentration and persistence of the medicinal smoke effect, so that the warmth and medicinal effect of moxibustion can be fully exerted.

The invention relates to the technical field of traditional Chinese medicine nephropathy treatment, and discloses an ultrasonic micronization traditional Chinese medicine permeation edema treatment device for traditional Chinese medicine nephropathy, which comprises a base, a liquid medicine treatment mechanism, a stand column, a shell, a positive pressure mechanism and a traditional Chinese medicine liquid permeation mechanism. The liquid medicine treatment mechanism realizes refining of traditional Chinese medicine liquid through ultrasonic micronization and a multi-stage screen drum, the positive pressure mechanism assists permeation of the traditional Chinese medicine liquid, and the skin contact layer provides an electrotherapy function. The device can significantly improve the molecular refining degree and skin absorption efficiency of the traditional Chinese medicine liquid, enhances the treatment effect, has the characteristics of convenient operation and compact structure, and is suitable for treatment of edema symptoms related to traditional Chinese medicine nephropathy.

The nephrotic patient lower limb edema nursing device comprises a placing base, a medicine fumigation assembly is arranged in the placing base, a lower limb placing pad is fixedly arranged on the upper surface of the placing base, two sets of grooves are formed in the upper portion of the lower limb placing pad and used for placing the lower limbs of the patient, and air holes are evenly formed in the surfaces of the grooves. The air holes are communicated with the interior of the lower limb placing pad, and the interior of the lower limb placing pad is communicated with the medicine fumigation assembly through a guide pipe; when the lower limbs of a patient are subjected to medicine fumigation treatment, the medicine efficacy of traditional Chinese medicine can permeate the skin, promote blood circulation, eliminate edema and relieve discomfort of the patient caused by edema, the massage heads of the massage assembly massage the lower limbs of the patient, acupuncture points can be stimulated, blood circulation is further promoted, and the nursing effect is enhanced. Compared with a single nursing means, the comprehensive nursing method can better meet diversified requirements of nursing of lower limb edema of the nephrotic patients.

The application discloses a chlorine-free and fluorine-free sodium ion aqueous solution and application thereof in beauty care, health care, stomach protection and diet seasoning, which is prepared from a high-purity sodium ion compound and pure water, and does not contain chlorine, fluorine, acid, alkali and harmful additives, and is in a neutral mild state. The core innovation of the application is that the negative effects of gastrointestinal stimulation, skin dryness and metabolic burden caused by chloride ions are abandoned, the natural salty taste, water penetration and locking and physiological regulation functions of sodium ions are completely retained, and based on the water formation of sodium ions and the osmotic pressure principle of human bodies, the internal and external use integration is realized. The sodium ion aqueous solution can be used for diet seasoning, stomach protection, electrolyte balance regulation when taken internally, and can penetrate into the deep layer of skin, lock water for a long time and repair the skin barrier when used externally. The product is safe, non-toxic, mild and non-irritating, has multiple functions, a clear mechanism and multiple values of beauty care, health care and seasoning, and is suitable for long-term and daily use of all kinds of people.

The present invention relates to a cosmetic device for penetration of a skin care preparation, and a main body unit and a cartridge unit constituting same. The main body unit for penetration of a skin care preparation, according to one embodiment of the present invention, comprises: a housing extending about a single axis; a rotating part provided to be rotatable relative to the housing about the single axis; and a non-rotating part provided to be rotatable relative to the housing about the single axis. Therefore, the skin care preparation is simply and efficiently delivered, and easy removal and buffering of the cartridge unit can be provided.

The present application relates to a kind of anti-aging protective composition containing camellia japonica extract and application, the liposome composition includes nuclear layer, shell layer and chitosan coating from inside to outside in turn;Wherein, the nuclear layer includes camellia japonica extract and DNA sodium;The shell layer includes lecithin, cholesterol, ceramide and enzymatic tea extract.The present application is wrapped by coating liposome encapsulation technology active substance, help active ingredient penetration skin, from promoting collagen synthesis, enhancing skin elasticity, antioxidant, repair damaged skin barrier etc. multiple dimensions Comprehensive improvement skin aging condition, realize significant anti-aging protective effect.