The invention discloses a multi-sensor and antagonistic drive based dexterous hand control system. The system comprises an antagonistic driven dexterous hand in tendon transmission, a joint angle sensor, a touch sensor in bionic skin, a joint force and torque sensor, a tendon tension sensor, a sensor management module, a driver control module and a central control module. According to the system,perception modes of different levels of force and touch are effectively decoupled, various sense information can be flexibly and comprehensively analyzed under different operating tasks, the control difficulty is simplified, and design complexity and cost of each type of sensor (and the bionic skin with touch) are reduced; and through the central control module of the system, the dexterous hand can avoid excessive relaxation or tensioning of the tendon, joint damping and joint rigidity of each joint can be controlled, the compliance operation and the anti-interference performance and robustness can be taken into account, and the system can still work reliably when the joint force and torque sensor or the tendon tension sensor is partially or completely lacked or works abnormally.