The invention discloses a three-dimensional space variable angle loading device. The three-dimensional space variable angle loading device comprises experiment test pieces, an acquisition system, a ground connection tool system, and a sensor system, a pulley system and a loading system which are connected through a steel wire a, wherein the experiment test piece comprises a test piece a, a test piece b and a test piece c, the ground connection tool system comprises multiple parallel ground grooves, the ground grooves are connected with a ground beam a and a ground beam b, the pulley system comprises a pulley a, a pulley b, a pulley c and a pulley d, the loading system comprises an MTS actuator connected with a counterforce wall, the sensor system comprises force sensors, and the acquisition system is a TDS602 data acquisition device. The three-dimensional space variable angle loading device solves problems of poor space loading angle accuracy and poor loading device adaptability existing in the prior art, the three-dimensional space variable angle loading device is suitable for random space angle loading, various parts are detachable, ground assembling is convenient and simple, end portions of the test pieces are provided with the force sensors, and the three-dimensional space variable angle loading device further has properties of accurate data and high precision.