The invention belongs to the field of oral cavity digital models, and particularly discloses an oral cavity tooth maxillofacial neck digital twinning model mapping system and an establishment method.The oral cavity tooth maxillofacial neck digital twinning model mapping system comprises a data acquisition module, a data processing module, a 3D printing module, a mechanical analysis module, a data scanning module, a digital twinning module and an output module; image data of soft and hard tissues of a maxillofacial region of a patient are collected, and face images, breath, pronunciation, saliva, blood and genes are collected; image data of soft and hard maxillofacial tissue of the patient are collected, wherein the image data of the jaw bone, the face and the neck of the patient are collected through CT, the intraoral scanner scans intraoral tooth data, and the face scanner scans the contour of the soft tissue of the face. According to the twinborn model, the difference of three-dimensional model data, biochemical data, language, breathing and facial expression changes of different individuals is fully considered, the optimal treatment scheme is screened, and the visual distress treatment effect is achieved.