48 results about "Phage Display Peptide Library" patented technology

The invention belongs to the technical field of biological pharmacy, and particularly discloses an LAG-3 and PD-L1 dual-targeting polypeptide and application thereof. The polypeptide P3E-D7 with high affinity to LAG-3 and PD-L1 is obtained through phage display peptide library screening and polypeptide structure optimization, the affinity of the polypeptide to LAG-3 and PD-L1 is high, and binding of LAG-3 / MHC-II and PD-1 / PD-L1 can be effectively blocked. The polypeptide coupled drug BsPep-IMDQ is obtained by coupling the polypeptide P3E-D7 and the imidazoquinoline IMDQ micromolecule drug, the toxic and side effects of the micromolecule drug can be effectively inhibited, polarization of M2 macrophages is inhibited, and activation of T cells is promoted, so that the growth of tumors is remarkably inhibited, and the polypeptide coupled drug has no obvious toxic and side effects and is suitable for clinical application. And a basis is provided for research and development of medicines for resisting tumors or other types of diseases.