Patents
Literature
Patsnap Copilot is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Patsnap Copilot

82results about How to "Effectively ensure" patented technology

Enhanced antiviral activity against foot and mouth disease

Previously, we showed that type I interferon (alpha / beta interferon [IFN-α / β]) can inhibit foot-and-mouth disease virus (FMDV) replication in cell culture, and swine inoculated with 109 PFU of human adenovirus type 5 expressing porcine IFN-α (Ad5-pIFN-α) were protected when challenged 1 day later. In this study, we found that type II pIFN (pIFN-γ) also has antiviral activity against FMDV in cell culture and that, in combination with pIFN-α, it has a synergistic antiviral effect. We also observed that while each IFN alone induced a number of IFN-stimulated genes (ISGs), the combination resulted in a synergistic induction of some ISGs. To extend these studies to susceptible animals, we inoculated groups of swine with a control Ad5, 108 PFU of Ad5-pIFN-α, low- or high-dose Ad5-pIFN-γ, or a combination of Ad5-pIFN-α and low- or high-dose Ad5-pIFN-γ and challenged all groups with FMDV 1 day later. The control group and the groups inoculated with either Ad5-pIFN-α or a low dose of Ad5-pIFN-γ developed clinical disease and viremia. However, the group that received the combination of both Ad5-IFNs with the low dose of Ad5-pIFN-γ was completely protected from challenge and had no viremia. Similarly the groups inoculated with the combination of Ad5s with the higher dose of Ad5-pIFN-γ or with only high-dose Ad5-pIFN-γ were protected. The protected animals did not develop antibodies against viral nonstructural (NS) proteins, while all infected animals were NS protein seropositive. No antiviral activity or significant levels of IFNs were detected in the protected groups, but there was an induction of some ISGs. The results indicate that the combination of type I and II IFNs act synergistically to inhibit FMDV replication in vitro and in vivo.
Owner:UNITED STATES OF AMERICA

Optimized control method for primary frequency regulation based on exergy storage correction of thermodynamic system of coal-fired unit

An optimized control method for a primary frequency regulation based on an exergy storage correction of a thermodynamic system of a coal-fired unit is provided. Through measuring and recording temperatures and pressures of working fluids and metal heating surfaces of the coal-fired unit thermodynamic system in real-time, an exergy storage amount of the thermodynamic system is obtained. During a transient process, according to an exergy storage variation before and after acting of each regulation scheme, a maximum power output of each scheme is obtained. Thereafter, through comparing the maximum power output with a maximum power regulation quantity required by a current frequency regulation, an optimal primary frequency regulation control scheme is selected, and a primary frequency regulation control logic is corrected, so as to be high-efficiently and accurately involved in the primary frequency regulation control and maintain a fast and stable grid frequency. The present invention improves a predictive accuracy of an actual effect of the various thermodynamic system regulation schemes and reduces a selection blindness of the primary frequency regulation schemes, so that an operation flexibility of the coal-fired power unit during the transient processes is greatly improved.
Owner:XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products