The invention relates to a manufacturing method for low-alloy super-thick steel plates with excellent low-temperature toughness. The method comprises the steps of raw material blank preparation, blankcutting, milling and cleaning, vacuum girth welding compounding, blank heating and rolling, super-thick steel plate heat treatment and the like. The thickness of one obtained extra-thick steel plateranges from 100 millimeters to 260 millimeters, the obtained super-thick steel plate has the yield strength ReH of 325MPa or above, the tensile strength Rm of 450MPa or above, the elongation of 21% orabove, the minus 20 DEG C side knock absorbed energy KV2 of 120J or above, the minus 40 DEG C side knock absorbed energy of 100J or above, and the minus 60 DEG C side knock absorbed energy of 60J orabove. The manufacturing method for the low-alloy super-thick steel plates with excellent low-temperature toughness has the advantages of being stable in raw material source, flexible in production organization, high in efficiency, high in yield, low in energy consumption, environmentally friendly and the like, and compared with a continuous casting billet direct rolling super-thick plate process,the investment cost of an expensive large-section continuous casting machine can be saved.