The invention provides a protective sheath, a hysteroscope with a protective sheath, and a nephroscope with a protective sheath, which are used to prevent the electrical connection wires connected with the endoscope from being polluted by dirt, including inner sleeves The outer sleeve and the outer sleeve, the outer sleeve is a cylindrical structure, the inner sleeve includes a straight portion and a flared portion, the flared portion is located at the insertion end side of the inner sleeve, and the side wall of the flared portion is provided with multiple strips extending from the flared portion to the straight portion. The groove of the inner sleeve forms a plurality of elastic pieces at the insertion end of the inner sleeve; the inner wall of the elastic sheet is formed with a connecting part that can be matched with the self-locking quick connector; there is a cavity between the inner sleeve and the outer sleeve, and the cavity is provided with a compression After the waterproof cover, one end of the waterproof cover is fixedly sleeved on the inner cover, and the other end of the waterproof cover can be pulled out from the non-insertion end of the protective cover. The protective sheath involved in the invention is light in weight, small in size, easy to operate, can effectively protect the electrical connection wires from being polluted during use, prevent the occurrence of end circuits, pollution, etc., has low production cost, and can be used as a disposable medical device. Equipment use.