The invention discloses a jacking construction method for a prefabricated frame with an inversely arranged oil top on a variable ramp. The method comprises the following steps: arranging a weak transition section at a gradient change point, namely breaking a concrete slide way to form a weak section of a soil foundation; inversely arranging the oil top at one end of the prefabricated frame, arranging a rear seat of the oil top in a mode of backing on the prefabricated frame, connecting a piston column of the oil top with a force transfer member bar on the back, applying jacking force to the back through the oil top, and enabling the rear seat of the oil top to push the prefabricated frame to move forward for jacking; and jacking the prefabricated frame, dismounting the force transfer member bar, performing following up pouring on step type concrete rear seats, mounting the force transfer member bar, jacking the prefabricated frame, dismounting the force transfer member bar, performing following up pouring on step type concrete rear seats, mounting the force transfer member bar, continuing to jack, and executing the processes circularly until the prefabricated frame is jacked in place according to the design. The jacking construction method for the prefabricated frame with the inversely arranged oil top on the variable ramp, disclosed by the invention, can be used for ensuring continuous and stable jacking construction of the prefabricated frame on the variable ramp.